HRT AND EXERCISE EFFECTS ON CENTRAL ARTERIAL COMPLIANCE

激素替代疗法和运动对中央动脉顺应性的影响

• 批准号: 7719544
• 负责人: Kerrie Moreau
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719544
• 关键词: Arteries; Carotid Arteries; Computer Retrieval of Information on Scientific Projects Database; Conjugated Estrogens; Estradiol; Estrogens; Exercise; Funding; Grant; Heart; Home environment; Hormone replacement therapy; Institution; Measures; Menopause; Neck; Nervous system structure; Oral; Outcome Study; Pharmaceutical Preparations; Placebos; Postmenopause; Protocols documentation; Randomized; Research; Research Personnel; Resources; Source; Ultrasonography; United States National Institutes of Health; Walking; Week; Woman; base; cardiovascular disorder risk; day; heart disease risk; improved; improved functioning; programs; protective effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increases in the stiffness of arteries located throughout the body are associated with an higher risk for heart disease. After menopause, women have a higher risk for cardiovascular disease possibly due to the loss of estrogen. The increased risk for cardiovascular disease may be due, in part, to the increase in the stiffness of the arteries. Hormone replacement therapy (HRT) and regular exercise have been shown to be associated with a lower risk for cardiovascular disease, and may be producing their protective effects through favorable effects on the walls of the artery. The proposed protocol will determine the effects of three different types of HRT and the combined effects of HRT and exercise on improving the stiffness of arteries located in your neck (carotid), as well as on improving the function of your heart and nervous system. Postmenopausal women will be randomly assigned to one of four groups: conjugated estrogen, oral estradiol, estrogen patch, or placebo (no medication). After 3 months, the women will be placed on a home-based endurance-exercise program consisting moderate intensity walking for 40-45 minutes a day, 5-7 days per week. The women will continue to take their HRT while participating in the 3 month walking program. Ultrasound images of the carotid artery and heart will be measured at the beginning of the study and after 6 months of the therapy. The primary outcome of the study will be to determine whether women taking HRT and/or exercise demonstrate an improvement in the stiffness or their arteries.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 全身动脉僵硬度的增加与患心脏病的风险增加有关。 绝经后，女性患心血管疾病的风险更高，这可能是由于雌激素的丧失。 心血管疾病风险增加的部分原因可能是动脉硬度增加。 激素替代疗法 (HRT) 和定期运动已被证明与降低心血管疾病风险相关，并且可能通过对动脉壁的有利作用产生保护作用。 拟议的方案将确定三种不同类型的 HRT 的效果以及 HRT 和运动对改善颈部（颈动脉）动脉硬度以及改善心脏和神经系统功能的综合效果。绝经后妇女将被随机分配到四组之一：结合雌激素、口服雌二醇、雌激素贴剂或安慰剂（无药物）。 3 个月后，这些女性将接受家庭耐力锻炼计划，包括每周 5-7 天、每天 40-45 分钟的中等强度步行。 这些女性将在参加为期 3 个月的步行计划的同时继续接受 HRT。 将在研究开始时和治疗 6 个月后测量颈动脉和心脏的超声图像。 该研究的主要结果将是确定接受激素替代疗法和/或锻炼的女性是否表现出动脉僵硬度的改善。