SUBCLINICAL CVD IN AFRICAN AMERICAN TYPE 2 DIABETICS

非裔美国人 2 型糖尿病患者的亚临床 CVD

• 批准号: 8167007
• 负责人: BARRY Ira FREEDMAN
• 金额: $ 10.56万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167007
• 关键词: African American; American; Bone Density; Calcium; Cardiovascular Diseases; Carotid Arteries; Cause of Death; Collection; Complications of Diabetes Mellitus; Computer Retrieval of Information on Scientific Projects Database; Coronary artery; Diabetes Mellitus; European; Family; Funding; Genes; Grant; Individual; Institution; Life Style; Measurement; Measures; Mediating; Methods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Relative (related person); Research; Research Personnel; Resources; Risk; Siblings; Source; Thick; Ultrasonography; United States National Institutes of Health; X-Ray Computed Tomography; cardiovascular disorder risk; diabetic; disability; ethnic difference; genetic risk factor; high risk; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) is the leading cause of death and disability in individuals with diabetes. African Americans are at particularly high risk for developing type 2 diabetes and diabetic complications, relative to European Americans. This study will measure the extent to which inherited factors (genes) contribute to the risk of developing CVD in African Americans with diabetes and evaluate the causes of ethnic differences in subclinical CVD. The risk for developing CVD in African Americans is thought to be mediated by both genes and lifestyle, but the size of the risk attributable to genes and their identity are unknown. This study will measure the size of that risk and search for genes that contribute to CVD in pairs of African American siblings with type 2 diabetes. Subclinical CVD will be evaluated using sophisticated, noninvasive, methods: ultrasound measurement of the thickness of carotid artery walls and measurement of calcium in coronary arteries using computed tomography (CT scans). Additional ancillary measures are obesity and bone density. This study will create a unique collection of African American diabetic families with associated information for the study of CVD. The identification of CVD risk genes would provide opportunities to develop new treatments to prevent or delay the onset of CVD in African American individuals with diabetes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 心血管疾病（CVD）是糖尿病患者死亡和残疾的主要原因。 与欧洲裔美国人相比，非洲裔美国人患 2 型糖尿病和糖尿病并发症的风险特别高。 这项研究将衡量遗传因素（基因）对患有糖尿病的非裔美国人患 CVD 风险的影响程度，并评估亚临床 CVD 种族差异的原因。 非裔美国人患心血管疾病的风险被认为是由基因和生活方式共同介导的，但基因造成的风险大小及其特性尚不清楚。 这项研究将测量这一风险的大小，并在患有 2 型糖尿病的非洲裔美国兄弟姐妹中寻找导致 CVD 的基因。 亚临床 CVD 将使用复杂的非侵入性方法进行评估：超声测量颈动脉壁的厚度以及使用计算机断层扫描（CT 扫描）测量冠状动脉中的钙。 其他辅助指标包括肥胖和骨密度。 这项研究将创建一个独特的非裔美国糖尿病家庭数据库，其中包含用于 CVD 研究的相关信息。 CVD风险基因的鉴定将为开发新疗法提供机会，以预防或延缓非洲裔美国糖尿病患者CVD的发病。