DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: RECRUITMENT OF THE FIRST SUBCOHORT AND FOLLOW-UP

产前和儿童健康差异机制数据协调中心：第一小组的招募和后续行动

基本信息

批准号：
10576717
负责人：
Seth Sherman
金额：
$ 56.73万
依托单位：
THE EMMES COMPANY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-01 至 2022-12-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10576717
关键词：
18 year old Address Affect Age-Months Beginning of Life Birth COVID-19 COVID-19 pandemic Characteristics Child Development Child Rearing Childhood Clinical Clinical Research Cohort Studies Collaborations Collection Contracts Data Data Collection Data Coordinating Center Data Management Resources Development Discrimination Disease Documentation Economically Deprived Population Eligibility Determination Enrollment Ensure Environment Ethnic Origin Etiology Family First Pregnancy Trimester Generations Gestational Age Health Health behavior Individual Inequality Infant Infant Development Infant Health Intervention Studies Interview Interviewer Knowledge Lead Life Life Cycle Stages Lifting Link Literature Maternal Health Measurement Measures Mediating Medical Records Mental Health Methods Monitor Names National Institute of Child Health and Human Development Neighborhoods Neonatal Observational Study Outcome Parents Participant Patient Recruitments Patient Self-Report Performance Persons Phase Phenotype Play Population Poverty Pregnancy Pregnancy Complications Pregnant Women Procedures Protocols documentation Psychiatric Diagnosis Psychopathology Race Research Research Design Research Personnel Risk Factors Role Sampling Services Ships Site Social support Socioeconomic Status Source Strategic Planning Stressful Event System Testing Training Umbilical Cord Blood United States United States National Institutes of Health Update Woman base biobank childhood adversity clinical research site cohort data quality design ethnic diversity fetal follow up assessment follow-up health disparity improved knowledge base neurodevelopment offspring pandemic disease perceived stress physical conditioning population health prenatal prospective protective factors racial disparity racial diversity recruit social disadvantage socioeconomics substance use theories transmission process

项目摘要

Health disparities in the United States have their origins as early as the prenatal period. Early life conditions including poverty and discrimination generate disparities in health over the life course that become further entrenched in the population through their transmission across generations. Parental mental health, which is strongly linked with social and economic disadvantage as well as child development, may play a key mediating role in the transmission of disparities across generation, but a persistent gap in the disparities literature is that both maternal and paternal psychopathology have not been fully considered as mechanisms nor measured using phenotypically validated approaches. As a result, though disparities in health are well documented, the developmental mechanisms that impact disparities at the very beginning of life are not, particularly those which lead to developmental deficits that emerge long before disease states. The National Institutes of Health (NIH) strategic plan (2016-2020) highlights the need for research to improve “understanding mechanisms that lead to disparities by race/ethnicity and socioeconomic status.” Such enhanced understanding is needed to clarify the etiology of disparities – particularly the specific exposures linked with social or economic disadvantage that impact early development. Advancing knowledge of the developmental mechanisms that generate disparities requires a more thorough understanding of how socioeconomic and race/ethnic status influence the determinants of development from gestation onward. To accomplish this, more in-depth measurement of potential causes of disparities is needed from more diverse samples starting earlier in the life course are needed than is currently available from existing studies.

美国的健康差异早在产前时期就已产生，包括贫困和歧视在内的早期生活条件造成了生命周期中的健康差异，并通过代代相传在人口中进一步根深蒂固。父母的心理健康与社会和经济劣势以及儿童发展密切相关，可能在代际传播差异中发挥关键的中介作用，但差异文献中持续存在的差距是，母亲和父亲的精神病理学都没有没有被充分考虑为机制，也没有使用经过表型验证的方法进行测量。因此，尽管健康方面的差异有据可查，但在生命之初影响差异的发育机制却没有，特别是那些导致早在疾病出现之前就出现的发育缺陷的机制。（NIH）战略计划（2016-2020）强调需要进行研究，以改善“对导致种族/民族和社会经济地位差异的机制的理解”。具有影响早期发展的社会或经济劣势。增进对产生差异的发育机制的了解需要更深入地了解社会经济和种族/族裔地位如何影响从妊娠开始的发育决定因素。为了实现这一目标，需要从更多样化的角度更深入地衡量差异的潜在原因。需要比目前现有研究提供的更早开始的样本。