Biocontainment Core

生物防护核心

基本信息

批准号：
10576205
负责人：
VIVEK Ramchandra NERURKAR
金额：
$ 19.35万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-14 至 2023-07-13
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10576205
关键词：
Affect Asia Biological Biological Sciences Bioterrorism Burn injury Businesses Caliber Centers of Research Excellence Certification Collaborations Communicable Diseases Communities Core Facility Detection Disease Outbreaks Early Diagnosis Educational workshop Effectiveness Elements Emerging Communicable Diseases Ensure Epidemic Equipment Extramural Activities Faculty Fees Funding Geographic Locations Goals Growth Hawaii Human Resources Infection Infectious Diseases Research Infrastructure Institutes International Laboratories Maintenance Marketing Medical Microbiology Mentors Mission Monitor National Center for Research Resources National Institute of Allergy and Infectious Disease National Institute of General Medical Sciences National Institute on Minority Health and Health Disparities Needs Assessment Periodicity Pharmacology Phase Population Prevention Process Productivity Publications Rapid diagnostics Research Research Activity Research Personnel Research Project Grants Research Training Resource Allocation Resources Role Safety Schedule Secure Sentinel Services Site Strategic Planning Structure System Techniques Therapeutic Time Training Training Activity Training Programs Training and Education Triad Acrylic Resin Tropical Medicine United States United States National Institutes of Health Universities Vaccines Virus Zoonoses base biocontainment facility career development effectiveness evaluation improved medical schools microbial multi-ethnic multidisciplinary operation outreach pathogenic microbe programs prospective research and development response satisfaction skills tool

项目摘要

Project Summary for the Biocontainment Core Hawaii's geographic location as a prominent international port and its strategic proximity to Asia makes it a natural sentinel post from which to monitor the emergence and spread of newly recognized infectious diseases and to investigate outbreaks of well-known microbial infections in the Asia-Pacific region. During the initial Phase I COBRE period, a multidisciplinary center was established to investigate emerging infectious diseases that impact Hawaii's multiethnic population. At that time, a state-of-the-art ABSL-3/BSL-3 biocontainment facility, located in the State-financed BioSciences Building, was developed as a Biocontainment Core. As the only facility of its kind for researchers in the entire State, the Biocontainment Core represents a valuable local and regional asset. For the Phase II COBRE period, the infrastructure for the Biocontainment Core was enhanced to support hypothesis-driven research projects that sought to develop rapid diagnostics, improved treatments and affordable vaccines for emerging infectious diseases. Directed by a senior virologist with assistance from a well-trained staff, the Biocontainment Core has provided opportunities for studying pathogenic microbes under BSL-2 and BSL-3 biocontainment; also, the Core has provided training workshops and assisted in the certification and permitting process for users. During COBRE Phases I and II, the Biocontainment Core focused on the triad of service, research and development, and education and training. These core functions will extend into Phase III to support the career development and research independence of faculty within the UH System and beyond. Further, a high priority during COBRE Phase III is to ensure the sustainability and growth of the Biocontainment Core. Thus, the overarching objective is to facilitate the transition of the Biocontainment Core into a sustainable state-of-the-art core facility capable of supporting high-caliber research on new, emerging and re-emerging infectious diseases. The objective will be achieved by (1) enhancing and streamlining core operations; (2) growing and diversifying the user base, capability, capacity and reach; and (3) strengthening the core infrastructure. It is envisioned that the Biocontainment Core will achieve each of the above-stated specific aims by the end of the Phase III COBRE. Moreover, the strong commitments by high-level institutional officials will ensure that core operations will be sustained during and beyond the Phase III COBRE period.

生物防护核心项目摘要夏威夷作为著名国际港口的地理位置及其毗邻亚洲的战略优势使其成为监测新发现的传染病的出现和传播的天然哨所疾病并调查亚太地区众所周知的微生物感染的爆发。期间第一阶段 COBRE 期间，建立了一个多学科中心来调查新出现的传染病影响夏威夷多种族人口的疾病。当时最先进的ABSL-3/BSL-3 生物防护设施位于国家资助的生物科学大楼内，是作为一个生物防护核心。作为全州唯一为研究人员提供的同类设施，生物防护中心核心代表了宝贵的当地和区域资产。对于第二阶段 COBRE 期间，生物防护核心得到增强，以支持旨在开发的假设驱动的研究项目针对新出现的传染病的快速诊断、改进的治疗和负担得起的疫苗。导演是生物防护核心由一名高级病毒学家在训练有素的工作人员的协助下提供在 BSL-2 和 BSL-3 生物防护下研究病原微生物的机会；此外，核心还有提供培训讲习班并协助用户进行认证和许可过程。在 COBRE 第一阶段和第二阶段期间，生物防护核心重点关注服务、研究和发展、教育和培训。这些核心功能将延伸到第三阶段以支持职业生涯夏威夷大学系统内外教师的发展和研究独立性。此外，高度优先 COBRE 第三阶段的目标是确保生物防护核心的可持续性和增长。因此，总体目标是促进生物防护核心转变为可持续的最先进的能够支持新的、正在出现的和重新出现的传染病的高水平研究的核心设施疾病。该目标将通过以下方式实现：(1) 加强和精简核心业务； (2) 生长和使用户基础、能力、能力和范围多样化；（三）强化核心基础设施。预计生物防护核心将在年底前实现上述每一项具体目标第三阶段 COBRE。此外，高层机构官员的坚定承诺将确保在第三阶段 COBRE 期间及之后将维持核心业务。