Novel Transparent, Ultra-soft Neuroelectrode Arrays Based on Nanomeshing Conventional Electrode Materials SUPPLEMENT

基于纳米网格的新型透明、超软神经电极阵列传统电极材料补充

基本信息

批准号：
10579663
负责人：
Michela Fagiolini
金额：
$ 23.46万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2023-08-31
项目状态：
已结题

项目摘要

Abstract The objective of our parent award RF1NS118301 is to develop and validate proof-of-concept, nanomesh- microelectrode-based, transparent, ultra-soft, high-density (NANOMESH) array with at least 256 high-performance nanomesh microelectrodes and artifact rejecting wireless data link. The proposed dissemination supplement is within the scope of the parent award, but beyond the original dissemination plans. As the focus of the parent award is to generate proof-of-concept for NANOMESH arrays, we decided at the time when applying for our parent award that a plan for dissemination of proposed technology in it may be premature. Over the past project duration, PI Fang’s lab has established the fabrication and testing of flexible nanomesh microelectrode arrays (MEAs) with up to 256-ch in wired connections. Although the parent award aims to achieve also ultra-softness for the arrays in addition to fully wireless system, wire-connected nanomesh MEAs are still highly useful and particularly suitable for electrophysiology applications with concurrent in vivo imaging, where the animals are going to be head-fixed anyway. This dissemination will not only fulfill some urgent needs in the community for such electrode arrays, it will also in turn, provide valuable feedback on both the further technology development and how to best disseminate novel neuroelectronic devices. Consequently, we feel it’s appropriate to pursue small dissemination efforts of our existing and/or easily-achievable wired, soft nanomesh MEAs, which will significantly benefit three end-user laboratories, while being highly synergistic with the parent award. This grant supplement will significantly facilitate the intended small dissemination efforts by (1) providing two pieces of equipment that will scale-up and automate the device fabrication process of soft nanomesh MEAs, (2) purchasing materials and supplies for building additional devices, (3) supporting research assistants in the PI’s lab to conduct training on the soft nanomesh MEAs being disseminated and their handling/utilization, and (4) supplying dedicated recording systems for one of our end-users for chronic experiments.

抽象的我们的母奖 RF1NS118301 的目标是开发和验证概念验证、纳米网格- 基于微电极的、透明的、超软的、高密度 (NANOMESH) 阵列，至少有 256 个高性能纳米网微电极和伪影抑制无线数据链路。传播补充属于家长奖励范围，但超出了原传播计划。由于母奖的重点是为 NANOMESH 阵列生成概念验证，因此我们决定申请我们的家长奖时，可能需要制定传播拟议技术的计划在过去的项目期间，PI Fang 的实验室已经建立了柔性的制造和测试。具有多达 256 通道有线连接的纳米网微电极阵列 (MEA)。除了全无线系统、有线连接之外，还旨在实现阵列的超柔软性纳米网 MEA 仍然非常有用，特别适合电生理学应用并行体内成像，无论如何，动物的头部都将被固定，这种传播不会发生。不仅满足了社区对这种电极阵列的一些迫切需求，它也将反过来提供有价值的关于进一步技术发展以及如何最好地传播新型神经电子学的反馈经过检查，我们认为对我们现有的和/或的进行小规模的传播工作是适当的。易于实现的有线、软纳米网 MEA，这将使三个最终用户实验室受益匪浅，同时与母公司奖项具有高度协同作用。该赠款补充将通过以下方式显着促进预期的小型传播工作：（1）提供两台设备将扩大和自动化软纳米网的设备制造过程 MEA，(2) 购买用于建造额外设备的材料和用品，(3) 支持研究助理在 PI 的实验室中对正在传播的软纳米网 MEA 及其特性进行培训处理/利用，以及 (4) 为我们的慢性病最终用户之一提供专用记录系统实验。