CLINICAL TRIAL: METABOLIC EFFECTS OF SHORT-TERM WALNUT CONSUMPTION IN METABOLIC

临床试验：短期食用核桃对代谢的影响

• 批准号: 7718926
• 负责人: CHRISTOS S MANTZOROS
• 金额: $ 2.02万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718926
• 关键词: Arginine; Biological Markers; Blood Vessels; Body Weight; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Consumption; Cross-Over Studies; Depth; Fatty acid glycerol esters; Funding; Grant; Health; Inflammatory; Institution; Juglans; Lipids; Macronutrients Nutrition; Magnesium; Metabolic; Metabolic syndrome; Micronutrients; Nutrient; Nuts; Observational Study; Outcome; Phytochemical; Placebo Control; Research; Research Personnel; Resources; Source; Trees; United States National Institutes of Health; Woman; cardiovascular disorder risk; insulin sensitivity; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Extensive epidemiologic evidence suggests that nut consumption decreases cardiovascular disease risk (CVD) and CVD outcomes. Tree nuts have some similar attributes, but differ in their magnesium, L-arginine, omega-three and other fat fractions. Walnuts have an optimal nutrient content to exert positive health effects. Walnuts have been shown to have a favorable effect on lipid profile and vascular reactivity but these effects alone do not explain the positive health effects observed in observational studies. In addition, the effect of walnuts on the metabolic syndrome as a whole has never been studied. To date the mechanisms of the effects of walnuts on inflammatory biomarkers, body weight and insulin sensitivity remain unknown. Walnuts include many potentially beneficial micronutrients and phytochemicals and in this study we propose to examine the effects of walnuts independent of macronutrient content. We plan to perform a placebo controlled cross-over study to examine in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 大量流行病学证据表明，食用坚果可降低心血管疾病风险 (CVD) 和 CVD 结局。坚果具有一些相似的特性，但其镁、L-精氨酸、欧米伽三和其他脂肪成分有所不同。 核桃具有最佳的营养成分，可以发挥积极的健康作用。核桃已被证明对血脂和血管反应性有良好的影响，但这些影响本身并不能解释观察性研究中观察到的积极健康影响。此外，核桃对整个代谢综合征的影响从未被研究过。迄今为止，核桃对炎症生物标志物、体重和胰岛素敏感性的影响机制仍不清楚。核桃含有许多潜在有益的微量营养素和植物化学物质，在这项研究中，我们建议检查核桃的影响，而与常量营养素含量无关。我们计划进行一项安慰剂对照交叉研究，以深入研究食用核桃对患有代谢综合征的男性和女性的短期影响。