Low cost and high performance time-of-flight PET detectors

低成本、高性能飞行时间 PET 探测器

基本信息

批准号：
10569636
负责人：
Joshua William Cates
金额：
$ 44.48万
依托单位：
UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10569636
关键词：
Academia Address Anodes Area Bismuth Cathodes Characteristics Clinical Coupled Data Detection Development Dose Electric Capacitance Electronics Elements Event Germination Hot Spot Image Image Enhancement Imaging Phantoms Industry Length Lesion Light Lutetium Measurement Measures Modernization Monte Carlo Method Names Neoplasm Metastasis Noise Pathway interactions Patients Performance Photons Play Positron-Emission Tomography Predisposition Probability Radiation Dose Unit Recovery Resolution Role Scanning Shapes Signal Transduction Silicon System Techniques Technology Temperature Time Tracer Visualization absorption advanced system analog cost cost effective density design detection sensitivity detector digital imaging study improved instrumentation interest light emission luminescence meter models and simulation novel operation photomultiplier photon-counting detector response signal processing trend ultraviolet uptake

项目摘要

Project Summary/Abstract There is a major push to substantially improve the sensitivity of positron emission tomography (PET) with systems comprising increased crystal volume and detectors with fast timing capabilities to better exploit 511 keV photon localization with time-of-flight PET (TOF-PET). For these efforts, there is a vital need for advances in TOF-PET detector technologies that provide excellent coincidence time resolution (CTR) and 511 keV photon detection efficiency at reduced cost. To address this, we propose to leverage novel readout electronics that optimize the single photon response shape and single photon time resolution (SPTR) of silicon photomultipliers (SiPMs) to accurately estimate 511 keV photon time of interaction with the mixed Cherenkov/luminescence (MCL) yield from bismuth germinate (BGO). SPTR does not strongly influence CTR for fast and bright scintillators, such as lutetium orthosilicate scintillators (LSO/LYSO). However, a moderate Cherenkov yield mixed with a weak luminescence response creates a more unique scenario where SPTR and single photon response shape play a major role in achievable CTR. With our electronic readout, <285 ps FWHM CTR is achievable for long and narrow BGO crystal elements suitable for clinical PET detectors. This is equivalent to CTR achieved by state-of-the-art (SoA) commercial PET detectors. The novel signal multiplexing strategies we propose to develop will allow us to maintain SoA CTR performance in large area detector modules at the same or reduced channel density than conventional TOF-PET detector designs. BGO is an extremely economical detector material, with a cost that is 4-to-5 fold lower than the standard LSO/LYSO scintillators used in all modern TOF-PET systems. We will develop TOF-PET detector modules with associated front-end signal processing and digital readout electronics. The technology will be ready for “plug-and-play” integration into reduced cost clinical TOF-PET systems and those that aim to explore ultra-sensitive PET systems with increased detection volume at reduced cost. The proposed PET detector technologies can have a significant impact on quantitative PET imaging. The image signal-to-noise-ratio enabled by the enormous boost in counts from high sensitivity PET systems can be employed to substantially reduce tracer dose and shorten scan time/increase patient throughput, or to better visualize and quantify smaller lesions/features in the presence of significant background, which are important features that can make PET more practical and lower cost, as well as help to expand its roles in patient management.

项目概要/摘要大力推动显着提高正电子发射断层扫描 (PET) 的灵敏度系统包括增加的晶体体积和具有快速定时功能的探测器，以更好地利用 511 利用飞行时间 PET (TOF-PET) 实现 keV 光子定位对于这些努力，迫切需要取得进展。 TOF-PET 探测器技术提供出色的符合时间分辨率 (CTR) 和 511 keV 为了解决这个问题，我们建议利用新型读出电子器件来提高光子检测效率。优化硅的单光子响应形状和单光子时间分辨率 (SPTR) 光电倍增管 (SiPM) 可准确估计 511 keV 光子与混合光子相互作用的时间萌发铋 (BGO) 的切伦科夫/发光 (MCL) 产量不会强烈影响 CTR。对于快速而明亮的闪烁体，例如原硅酸镥闪烁体（LSO/LYSO），然而，其强度适中。切伦科夫产量与弱发光响应混合创造了一个更独特的场景，其中 SPTR 和单光子响应形状在可实现的 CTR 中发挥着重要作用，使用我们的电子读数，<285 ps。对于适用于临床 PET 探测器的长而窄的 BGO 晶体元件，可以实现 FWHM CTR。相当于最先进 (SoA) 商用 PET 探测器实现的 CTR。我们建议开发的策略将使我们能够在大面积探测器中保持 SoA CTR 性能与传统 TOF-PET 探测器设计相比，模块具有相同或更低的通道密度。极其经济的探测器材料，成本比标准 LSO/LYSO 低 4 至 5 倍我们将开发用于所有现代 TOF-PET 系统的闪烁体以及相关的 TOF-PET 探测器模块。该技术将为“即插即用”做好准备。集成到降低成本的临床 TOF-PET 系统以及旨在探索超灵敏 PET 的系统中所提出的 PET 检测器技术可以具有增加检测量的系统。巨大的图像信噪比对定量 PET 成像产生重大影响。高灵敏度 PET 系统的计数增加可用于大幅减少示踪剂剂量和缩短扫描时间/增加患者吞吐量，或更好地可视化和量化较小的病变/特征显着背景的存在，这是可以使 PET 更实用且更低的重要特征成本，并有助于扩大其在患者管理中的作用。