An Ecological Investigation of Acute Next-Day Effects of Alcohol Use on Daily Cognitive Functioning

饮酒对日常认知功能的第二天急性影响的生态学调查

• 批准号: 10570499
• 负责人: Ashley Nicole Linden-Carmichael
• 金额: $ 23.06万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570499
• 关键词: Activities of Daily Living; Acute; Age; Alcohol abuse; Alcohol consumption; Alcohols; Attention; Behavior; Brain; Buffers; Cannabis; Characteristics; Clinical; Cognition; Cognitive; Corpus Callosum; Data; Development; Early Intervention; Elderly; Episodic memory; Event; Female; Health; Heavy Drinking; Impaired cognition; Individual; Injury; Interruption; Intervention; Intoxication; Investigation; Light; Memory; Monitor; Moods; National Institute on Alcohol Abuse and Alcoholism; Outcome; Overdose; Patient Self-Report; Performance; Persons; Positioning Attribute; Prevention; Public Health; Reporting; Research; Risk; Role; Sampling; Severities; Short-Term Memory; Signal Transduction; Sleep; Strategic Planning; Subgroup; Symptoms; Time; United States Substance Abuse and Mental Health Services Administration; Work; age group; alcohol effect; alcohol measurement; alcohol risk; alcohol use disorder; binge drinking; cognitive function; cost estimate; diaries; drinking; executive function; experience; hangover; high intensity drinking; high risk; indexing; male; marijuana use; meetings; middle age; morphometry; sex; sexual assault; substance use; young adult

PROJECT SUMMARY/ABSTRACT Heavy and frequent alcohol use remains a key public health concern, particularly among young adults. Recent experimental evidence has shown that a single heavy drinking event is associated with short-term structural changes in the brain among a sample of young adults and preliminary diary evidence suggests alcohol use may impact concentration and working memory capacity. As young adults are at highest risk of alcohol use relative to any other age group, such immediate structural changes may signal a need for early prevention and intervention efforts, although the long-term impacts of alcohol use on the brain within a sample of young adults remain unknown. A key indicator of longer-term cognitive outcomes is observed functional impacts on young adult behavior in their daily lives. Changes in daily behaviors during this period could negatively impact cognitive health into midlife. Our team aims to collect intensive data across a 21-day period from a sample of 250 young adults to explore the acute, next-day (post-intoxication) effects of alcohol use on cognitive functioning overall, across multiple timeframes, and by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). We also seek to examine day-level and person-level moderators to inform moments and subgroups at greatest risk and in need of early targeted prevention and intervention efforts. Specifically, the current exploratory and developmental R21 has three aims. Aim 1 will (a) examine acute, next-day effects of any alcohol use on cognitive functioning (episodic memory, executive functioning, working memory) and across various time frames (i.e., upon waking only or persisting throughout the day); and (b) examine whether these daily associations differ by type of drinking episode (light drinking, binge drinking, high-intensity drinking, blackout drinking). Aim 2 will examine day-level moderators (hangover symptoms, mood, sleep, prior day cannabis, other substance use) that may buffer or exacerbate day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. Finally, Aim 3 will examine person-level variables (sex, baseline alcohol use severity, general cognitive functioning) as moderators of day-level associations between alcohol use (any drinking, light drinking, binge drinking, high-intensity drinking, blackout drinking) and cognitive functioning. By identifying the acute impacts of varying levels of alcohol use intensity on next-day cognitive functioning as well as the day- and person-level characteristics that moderate these associations, our findings will have critical implications for the role of alcohol use on everyday cognitive functioning and highlight subgroups most in need of monitoring and early intervention. Findings from this exploratory and developmental R21 will also position our team well to ultimately examine whether day-level associations accumulate and are indicative of later alcohol-related and cognition-related problems.

项目摘要/摘要 大量和频繁的饮酒仍然是一个关键的公共健康问题，尤其是在年轻人中。最近的 实验证据表明，一个重型饮酒事件与短期结构有关 年轻人样本中大脑的变化和初步日记证据表明，使用酒精可能 影响集中和工作记忆能力。因为年轻人的饮酒风险最高 对于任何其他年龄段，这种直接的结构变化可能表明需要早期预防和 干预工作，尽管在年轻人样本中，酒精使用对大脑的长期影响 仍然未知。观察到长期认知结果的关键指标是对年轻人的功能影响 成人日常生活中的行为。在此期间，日常行为的变化可能会对 认知健康成为中年。我们的团队旨在从一个21天的时间内收集密集数据 250名年轻人探索酒精使用对认知能力的急性，急诊（后施毒性）的影响 总体运作，跨多个时间表以及饮酒类型（轻饮用，暴饮暴食， 高强度饮酒，停电饮酒）。我们还试图检查日间和人级主持人 为最大风险的时刻和亚组提供信息，需要提早预防和干预 努力。具体而言，当前的探索性和发展性R21具有三个目标。目标1将（a）检查 任何酒精使用对认知功能的急性，下一天的影响（情节记忆，执行功能， 工作记忆）和各个时间范围（即，全天仅醒来或持续醒来）；和 （b）检查这些日常协会是否因饮酒类型（轻度饮酒，暴饮暴食）是否有所不同 高强度饮酒，停电饮酒）。 AIM 2将检查日级主持人（宿醉症状， 心情，睡眠，前一日大麻，其他药物使用）可能会缓冲或加剧日间的关联 在饮酒（任何饮酒，饮酒，暴饮暴食，高强度饮酒，停电饮酒）之间 认知功能。最后，AIM 3将检查人级变量（性别，基线饮酒严重程度， 一般认知功能）作为酒精使用之间日间关联的主持人（任何饮酒，光 饮酒，暴饮暴食，高强度饮酒，停电饮酒）和认知功能。通过识别 不同水平的酒精使用强度对第二天的认知功能以及一天的急性影响 - 以及使这些关联的人级特征，我们的发现将对 酒精使用在日常认知功能上的作用，并突出显示最需要监视的亚组 和早期干预。此探索性和发展性R21的发现也将使我们的团队适应 最终检查日间层面的关联是否积累，并表明以后与酒精有关 与认知有关的问题。