Training in Translational Immunology Research

转化免疫学研究培训

• 批准号: 10559487
• 负责人: Megan Sykes
• 金额: $ 29.82万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559487
• 关键词: Research; Training; translational immunology

Project Summary The field of immunology has exploded in the past decade, mainly as a result of technical developments enabling the study of complex organized structures and systems. Translational immunology research is immunological research that is oriented toward human immune diseases or therapies, ultimately aiming to convert basic discoveries made in laboratories into improved clinical therapies. Translational immunology encompasses molecular and animal research that addresses human diseases while emphasizing studies of the human immune system in an iterative “bench to bedside and back” approach. Because control of immunological processes is the goal of research in cancer, infectious disease, transplantation and autoimmunity, knowledge gained in one area is relevant to the other areas of applied immunology, resulting in a need for “horizontal translation” between disciplines. In order to harness the revolutionary leaps that have been made in our ability to study and control the human immune system, multidisciplinary training is needed that integrates knowledge from multiple disciplines at the basic and clinical levels and teaches young scientists how to use and analyze big data obtained from high throughput platforms such as next generation sequencing, proteomics, lipidomics and metabolomics. Analyzing these datasets increasingly demands cutting-edge bioinformatics capabilities that must be integrated into training the next generation of translational immunologists. We are proposing an integrative training program to meet this need by bringing together 29 established investigators at Columbia University Irving Medical Center (CUIMC) and offering mentored research opportunities in six complementary fields of immunology: basic immunology, developmental immunology, immunity to pathogens, tumor immunology, transplantation . immunology and autoimmunity. Cutting-edge research along these themes will be supported by the outstanding Department of Systems Biology at CUIMC. We believe this comprehensive program will expose trainees to cutting edge translational immunology research that integrates bioinformatics analyses The ultimate goal of our program is to provide fellows with the necessary competence to become future leaders in translational immunology.

项目摘要 免疫学领域在过去十年中探索了，主要是由于技术发展的结果 复杂的有组织结构和系统的研究。转化免疫学研究是免疫学 针对人类免疫疾病或疗法的研究，最终旨在转变基本 在实验室中发现的发现改善了临床疗法。翻译免疫学包括 分子和动物研究解决人类疾病的同时强调人类免疫的研究 系统以迭代的“卧床床和背部”的方式进行。因为控制免疫过程是 癌症研究，传染病，移植和自身免疫的目标的目标 区域与应用免疫学的其他领域有关，导致需要“水平翻译” 学科。为了利用我们学习和控制能力取得的革命性飞跃 需要人类免疫系统，需要多学科培训，以整合来自多个的知识 在基本和临床水平上的学科，并教年轻科学家如何使用和分析获得的大数据 从高吞吐量平台（例如下一代测序，保护性，脂肪组学和代谢组学）。 分析这些数据集越来越多地要求必须集成的尖端生物信息学功能 培训下一代翻译的免疫学家。我们正在提出一项综合培训计划 通过在哥伦比亚大学欧文医学中心汇集29名固定调查员来满足这一需求 （CUIMC）并在六个完整的免疫学领域提供重要的研究机会：基本 免疫学，发育免疫学，病原体免疫学，肿瘤免疫学，移植 。 免疫学和自身免疫。沿这些主题的尖端研究将得到杰出的 CUIMC系统生物学系。我们相信这个全面的计划将使培训接触 融合生物信息学分析的最终转化免疫学研究是我们的最终目标 计划是为研究员提供必要的能力，以成为转化的未来领导者 免疫学。