DEVELOPMENT OF IGA NEPHROPATHY IN COMMON MARMOSETS

普通狨猴 IGA 肾病的发展

• 批准号: 7715497
• 负责人: Andrew George Plaut
• 金额: $ 5.52万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715497
• 关键词: Antigen-Antibody Complex; Antigens; Callithrix jacchus jacchus; Chronic Kidney Failure; Complex; Computer Retrieval of Information on Scientific Projects Database; Deposition; Development; Dialysis procedure; Funding; Grant; Immunoglobulin A; Injury; Institution; Kidney Diseases; Kidney Failure; Kidney Glomerulus; Lead; Life; Physical Dialysis; Renal function; Research; Research Personnel; Resources; Source; Transplantation; United States National Institutes of Health; loss of function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. IgA nephropathy is a common, chronic kidney disease characterized by the deposition of lgA1-predominant immune complexes in the renal glomerulus. These complexes, whose antigens are unknown, appear early in life, and they eventually lead to glomerular injury, loss of renal function, and the need for dialysis or transplantation. Because loss of function takes decades to develop, there is an opportunity to intervene before the onset of renal insufficiency.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 IgA 肾病是一种常见的慢性肾脏疾病，其特征是肾小球中以 lgA1 为主的免疫复合物沉积。这些抗原未知的复合物在生命早期出现，最终导致肾小球损伤、肾功能丧失以及需要透析或移植。由于功能丧失需要几十年的时间才能形成，因此有机会在肾功能不全发生之前进行干预。