Shared Resource 01: Biomedical Informatics (BISR)

共享资源 01：生物医学信息学 (BISR)

• 批准号: 10090004
• 负责人: Kevin Robert Coombes
• 金额: $ 15.19万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-12 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090004
• 关键词: Abbreviations; Adverse event; Algorithms; Area; Bioinformatics; Bioinformatics Shared Resource; Biometry; Budgets; Cancer Biology; Cancer Center Support Grant; Cancer Control; Cancer Hospital; Chemoprevention; Clinical; Clinical Data; Clinical Treatment; Clinical Trials; Comparative Pathology; Complex; Comprehensive Cancer Center; Computational Biology; DNA; Data; Data Set; Data Storage and Retrieval; Faculty; Flow Cytometry; Fostering; Funding; Future; Gene Expression; Genomics; Genomics Shared Resource; Goals; Grant; Health; Immunologic Monitoring; Immunooncology; Informatics; Information Technology; Institutes; Institution; Institutional Review Boards; Intervention; Intramural Research Program; Leadership; Left; Literature; Malignant Neoplasms; Medical center; Metagenomics; Microscopy; Molecular Carcinogenesis; Monitor; Ohio; Oncology; Participant; Patients; Pediatric Hospitals; Pharmaceutical Chemistry; Population Sciences; Process; Proteomics; Protocols documentation; Publications; Records; Reporting; Research; Research Institute; Research Personnel; Resource Sharing; Safety; Services; Source; Surveys; System; Technology; The Cancer Genome Atlas; Therapeutic; Third Generation Sequencing; Translational Research; Universities; Untranslated RNA; Visual; Work; animal imaging; anticancer research; arm; biobank; biomedical informatics; cancer care; data analysis pipeline; data de-identification; data management; data visualization; data warehouse; digital imaging; drug sensitivity; falls; genomic data; improved; instrumentation; leukemia; leukemia tissue bank; member; metabolomics; next generation sequencing; novel; pathology imaging; programs; recruit; single cell sequencing; tool

PROJECT SUMMARY – BIOINFORMATICS SHARED RESOURCE (BISR) The BISR is an essential shared resource that supports a wide range of studies with bioinformatics and computational biology needs, ranging from next generation sequencing (NGS) to data management in population science studies. Housed within the Department of BMI, the BISR's goal is to leverage a variety of informatics services, ranging from analysis of omics datasets to patient/participant-centered data instrumentation, access, and management tools and processes. The Specific Aims of the BSR are to: 1) Provide state of the art bioinformatics and computational biology services; and 2) Provide OSUCCC investigators with services, expertise and access to technology platforms in support of heterogeneous and multi-dimensional biomedical data management requirements. Over the current grant cycle, Drs. Kevin Coombes (TT) and Lang Li (CB) assumed leadership of BISR, replacing Drs. Philip Payne and Jeffrey Parvin. During the current funding cycle, a Memorandum of Understanding (MOU) was established for the Department of Biomedical Informatics (BMI) and the OSUCCC to support 5 faculty at 10% per year for 3 years within BISR as they transition to grant funding, on a rolling basis, to provide non-chargeable, cancer focused bioinformatics work for OSUCCC membership and/or cancer focused researchers. Additional major changes for BISR include supporting the enhancement of the Genomics Shared Resource (GSR) to incorporate newly developed shared services with Nationwide Children's Hospital (NCH); and added capabilities to support studies involving data from single-cell sequencing, long-read (third generation) sequencing, metabolomics, and metagenomics. BISR has added five new faculty to support the areas of (1) computational optimization for drug sensitivity prediction (Cheng), (2) proteomics, and functional annotation of DNA non-coding regions (Zhang), (3) metabolomics and metagenomics (Mathe), (4) single-cell sequencing (Ma), and (5) long-read sequencing (Au). BISR supported Biospecimen Services Shared Resource (BSSR) projects (Total Cancer Care [TCC] and the Oncology Research Information Exchange Network [ORIEN]) by establishing a data warehouse of patient records with de-identified data. During the current funding cycle, the BISR supported 115 publications (25 > 10 impact factor), 134 users, and 32 NCI grants including 5 P01s, 2 P50s, 13 R01s, 3 R21s, 1 R50, 2 U01s, 1 U10, 1 UG1, involving members from all five programs. Over the next grant cycle, BISR will enhance services for “integromics”, e.g., the integration of disparate source of both omics and clinical data. BISR will be a critical part of the Immune Monitoring and Discovery Platform (IMDP), an overarching approach for fostering interactions among shared resources for complex immuno-oncology projects. The annual budget of the BISR is $1,122,279, yet the CCSG request is $106,905. As such, the BISR leverages extensive institutional support and seeks only 9.5% support from CCSG funds.

项目摘要 - 生物信息学共享资源（BISR） BISR是一种基本的共享资源，它支持具有生物信息学和的广泛研究 计算生物学需求，从下一代测序（NG）到人群的数据管理 科学研究。 BISR的目标是在BMI部门内，是利用各种信息 服务，从OMIC数据集的分析到患者/以参与者为中心的数据仪器，访问， 以及管理工具和流程。 BSR的具体目的是：1）提供最先进的状态 生物信息学和计算生物学服务； 2）为OSUCCC调查人员提供服务， 专业知识和进入技术平台，以支持异质和多维生物医学 数据管理要求。在当前的赠款周期中，博士。 Kevin Coombes（TT）和Lang Li（CB） 在BISR的领导下，取代了Drs。菲利普·佩恩（Philip Payne）和杰弗里·帕尔文（Jeffrey Parvin）。在当前的资金周期中 为生物医学信息学部（BMI）和 OSUCCC以每年为10％的教师在BISR中以每年10％的价格在BISR中授予授予资金， 滚动基础，为OSUCCC会员和/或 以癌症为中心的研究人员。 BISR的其他重大更改包括支持增强 基因组学共享资源（GSR）与全国儿童合并新开发的共享服务 医院（NCH）；并增加了支持涉及单细胞测序数据的研究的功能 （第三代）测序，代谢组学和宏基因组学。 BISR增加了五个新教师来支持 （1）对药物敏感性预测（Cheng），（2）蛋白质组学和功能性的计算优化的区域 DNA非编码区域（Zhang），（3）代谢组学和元基因组学（MATHE）的注释，（4）单细胞 测序（MA）和（5）长阅读测序（AU）。 BISR支持的生物循环服务共享资源 （BSSR）项目（总癌症护理[TCC]和肿瘤研究信息交换网络[ORIEN]） 通过建立具有去识别数据的患者记录的数据仓库。在当前的资金周期中 BISR支持115个出版物（25> 10个影响因素），134位用户和32个NCI赠款，包括5个P01，2个P50， 13 R01，3 R21，1 R50、2 U01，1 U10、1 UG1，涉及所有五个程序的成员。在下一个赠款中 循环，BISR将增强“集成学”的服务，例如，OMICS和 临床数据。 BISR将是免疫监控和发现平台（IMDP）的关键部分，这是一个总体 用于在复杂的免疫肿瘤项目中共享资源之间互动的方法。一年一度 BISR的预算为$ 1,122,279，但CCSG请求为$ 106,905。因此，BISR利用了广泛的 机构支持，仅寻求CCSG基金的9.5％的支持。