CC: Biostatistics Core

CC：生物统计学核心

• 批准号: 8731340
• 负责人: Kevin Robert Coombes
• 金额: $ 6.59万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-12 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8731340
• 关键词: Animal Model; Automation; Biochemical; Bioinformatics; Biological Assay; Biometry; Biostatistics Core; Cancer Center; Caring; Cell Line; Clinical; Clinical Trials; Data; Data Analyses; Databases; Development; Doctor of Medicine; Dose; Ensure; Epidemiology; Frequencies; Gene Chips; Human Resources; Institution; Laboratory Research; Link; Lung; Malignant neoplasm of lung; Manuscripts; Measurement; Medical center; Participant; Phase; Preparation; Procedures; Proteins; Research; Research Personnel; Single Nucleotide Polymorphism; Statistical Models; Texas; Time; Universities; Work; austin; base; career; computerized tools; cytokine; data management; design; flexibility; innovation; member; models and simulation; programs; research study; response; symposium; translational clinical trial

SPORE Core C: Biostatistics Core. The research proposed by The University of Texas SPORE in Lung Cancer encompasses a broad range of activities, including studies in cell lines, animal models, and clinical trials. These studies will generate many different types of data, including not only conventional clinical, epidemiological, biochemical, and immunohistochemical measurements, but also dose response curves, gene expression microarrays, reverse phase protein lysate arrays (RPPA), cytokine assays, and assessments of the frequency of single nucleotide polymorphisms (SNPs). The Biostatistics Core provides comprehensive biostatistics expertise to ensure the statistical integrity and to optimize data analysis of the studies by the SPORE, which are conducted at the Southwestern Medical Center (UTSW) and the M.D. Anderson Cancer Center (MDACC). The Core assists investigators with the proper planning of experiments, cooperates with Core D (Bioinformatics) to manage experimental data generated by Lung SPORE projects, and conducts statistical analyses for Lung SPORE investigators. The Core has the flexibility to match personnel to the evolving needs of existing and developmental SPORE projects. Members of the Core participate in monthly SPORE video conferences linking researchers at UTSW in Dallas, TX and M.D. Anderson Cancer Center in Houston, TX, and at times investigators at other institutions (e.g. University of Texas, Austin), ensuring that proper consideration is taken of biostatistics and data management issues during all phases of SPORE experiments. To carry out its responsibilities, the Core has the following Specific Aims: Aim 1: To provide valid statistical designs of laboratory research, clinical trials and translational experiments arising from the ongoing research of the SPORE. Aim 2: To oversee and conduct the innovative statistical modeling, simulations, and data analyses needed by the Projects, Developmental and Career Projects, and the other Cores to achieve their specific aims. Aim 3: To ensure that the results of all Projects are based on well-designed experiments, appropriately interpreted, and to assist in the preparation of manuscripts describing these results. Aim 4: To work closely with Core D (Bioinformatics) in the configuration of the integrated database application programming interface (API) to facilitate automation of statistical analysis procedures and development of computational tools, and make them available to all SPORE participants.

孢子核C：生物统计学核心。德克萨斯大学孢子在肺部提出的研究 癌症包括广泛的活动，包括在细胞系，动物模型和临床上进行的研究 试验。这些研究将产生许多不同类型的数据，不仅包括常规临床， 流行病学，生化和免疫组织化学测量，但也是剂量反应曲线， 基因表达微阵列，反相蛋白裂解液阵列（RPPA），细胞因子测定和 评估单核苷酸多态性（SNP）的频率。生物统计学核心提供 全面的生物统计学专业知识，以确保统计完整性并优化数据分析 孢子的研究是在西南医学中心（UTSW）和医学博士进行的。 安德森癌症中心（MDACC）。核心协助调查人员对实验进行适当的计划， 与核心D（生物信息学）合作管理由肺孢子项目产生的实验数据， 并对肺孢子研究人员进行统计分析。核心具有匹配的灵活性 对现有和发展孢子项目不断发展的需求的人员。核心成员 参加每月的孢子视频会议，将在德克萨斯州达拉斯市UTSW的研究人员联系起来。 德克萨斯州休斯敦的安德森癌症中心，有时以及其他机构的调查人员（例如 德克萨斯州奥斯汀），确保对生物统计学和数据管理问题进行适当的考虑 在孢子实验的所有阶段。为了履行其职责，核心具有以下 具体目的： 目标1：提供实验室研究，临床试验和翻译实验的有效统计设计 由孢子正在进行的研究引起。 目标2：监督和进行创新的统计建模，模拟和所需的数据分析 通过项目，发展和职业项目以及其他核心，以实现其特定目标。 目标3：确保所有项目的结果均基于精心设计的实验，适当地 解释，并协助制备描述这些结果的手稿。 目标4：在集成数据库的配置中与Core D（生物信息学）紧密合作 应用程序编程接口（API）促进统计分析程序的自动化和 开发计算工具，并使所有孢子参与者都可以使用。