Core E: Laboratory and biobehavioral marker core

核心 E：实验室和生物行为标记核心

基本信息

批准号：
10090667
负责人：
Steven Daniel Douglas
金额：
$ 23.82万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-03 至 2023-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10090667
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Autoimmunity Behavior Therapy Behavioral Big Data Biochemical Markers Bioinformatics Biological Biological Assay Biological Markers Biometry Body Fluids Cardiovascular system Cells Cerebrovascular Circulation Clinical Clinical Data Clinical assessments Cognitive Collaborations Data Data Set Databases Development Diffusion Disease Dopamine Emotions Enrollment Functional Magnetic Resonance Imaging Genomic DNA Genotype Gur HIV HIV Infections Health Image Immune response Immunity Immunosuppression Immunotherapy Individual Infection Inflammation Intervention Intervention Studies Kidney Laboratories Leadership Link Magnetic Resonance Imaging Measurement Measures Medical Mental Health Mental disorders Metabolic Mission Modeling Molecular Virology Monitor Morbidity - disease rate Neurocognitive Neuropsychology Outcome Output Participant Pathway interactions Pediatric Hospitals Pennsylvania Persons Pharmacology Phenotype Philadelphia Physiological Pilot Projects Plasma Population Positioning Attribute Positron-Emission Tomography Psychiatry Public Health Informatics Quality Control Records Research Research Personnel Resources Rest Rewards Role Sampling Schools Sensory Receptors Serotonin Serum Specimen Spin Labels Standardization Stress Structure Techniques Testing Therapeutic Universities Viral Work behavior test behavioral pharmacology biobank biobehavior biomedical informatics blood oxygen level dependent bone brain behavior cohort comorbidity computerized computerized data processing data management design immune activation laboratory experiment medical schools metabolomics microbiome nervous system disorder neuroAIDS neurobehavioral neuroimaging novel programs quality assurance ranpirnase repository single photon emission computed tomography transcriptome sequencing

项目摘要

CORE E: ABSTRACT/SUMMARY Consistent with the Center's theme, the mission of Core E is to facilitate a broad range of biological and behavioral intervention studies that are designed to optimize psychiatric, behavioral, and medical outcomes among HIV infected individuals. The Core will perform assays for all Pilot Projects, as well as design and implement novel assays. This Core will perform laboratory and imaging assessments that define the mental illnesses and co-morbidities related to HIV/AIDS and unique modeling and measurements related to various behavioral and pharmacologic interventions. The Core will benefit from the major strengths of the Perelman School of Medicine (PSOM), CHOP, Centers, Departments, and Schools at UPenn. We will identify specific and potentially unique biomarkers which are related to mental illness and to comorbidities of HIV/AIDS. These data will be collected for all subjects to be studied in pilots and other Cores. The Core will perform assays of body fluids and cells including markers of immunity, inflammation, stress, and health. The Core will also carry out neuroimaging and neurocognitive measures. The Core will assessments related to therapeutics for HIV, mental health, and co-morbidities. The Core is directed by two senior investigators, Drs. Douglas and Gur. The Core will support the Center's scientific agenda and developmental program. This Core resource will closely interact with existing resources at UPenn, which are central to the mission of the PMHARC. The Core Director, Douglas, and Co-Director, Gur, are in leadership roles at UPenn. The Core will be uniquely positioned to carry out and monitor the quality control and quality assurance of standardized selected imaging, biochemical markers, neuropsychological behavioral testing, and laboratory testing. The Core will work closely with all the other PMHARC Cores, and most closely with the Clinical Assessment Core, in an effort to gather integrated 'state-of-the-art' biomedical and behavioral data on a cohort of HIV+ persons with a variety of mental illnesses in an effort to better understand disease trajectories, morbidities and clinical outcomes.

核心E：摘要/摘要与中心的主题一致，核心E的使命是促进广泛的生物学和旨在优化精神病，行为和医学结果的行为干预研究在艾滋病毒感染的人中。核心将对所有试点项目以及设计和设计进行测定实施新颖的测定。该核心将进行实验室和成像评估，以定义精神与艾滋病毒/艾滋病有关的疾病和合并症以及与各种相关的独特建模和测量行为和药理干预措施。核心将从佩雷尔曼的主要优势中受益 upenn的医学院（PSOM），CHOP，中心，部门和学校。我们将确定具体以及与精神疾病和艾滋病毒/艾滋病合并症有关的潜在独特的生物标志物。这些将收集数据，以便在飞行员和其他核心中研究所有受试者。核心将执行测定体液和细胞，包括免疫，炎症，压力和健康的标志。核心也将携带消除神经影像学和神经认知措施。与艾滋病毒治疗剂有关的核心意愿评估，心理健康和合并症。核心由两名高级调查员Drs指导。道格拉斯和古尔。这核心将支持该中心的科学议程和发展计划。这个核心资源将密切与UPENN的现有资源互动，这是PMHARC任务的核心。核心主任，道格拉斯（Douglas）和联合导演古尔（Gur）担任乌普恩（Upenn）的领导职务。核心将是独特的位置淘汰并监视标准化成像，生化的质量控制和质量保证标记，神经心理学行为测试和实验室测试。核心将与所有其他PMHARC核心，最与临床评估核心最紧密的核心，以收集综合艾滋病毒+患者的“最先进”生物医学和行为数据有多种精神疾病为了更好地了解疾病轨迹，病态和临床结果。