Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

急性护理研究和农村差异生物医学卓越研究中心

基本信息

批准号：
10090065
负责人：
Douglas B Sawyer
金额：
$ 259.69万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-10 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10090065
关键词：
Acute Address Adult Antibiotic Prophylaxis Antibiotics Area Bioethics Caring Center for Translational Science Activities Centers of Research Excellence Childhood Clinical Clinical Research Collaborations Communities Consent Core Facility Critical Care Development Disadvantaged Doctor of Pharmacy Doctor of Philosophy Emergency Care Emergency Situation Emergency medical service Encephalopathies Ensure Event Foundations Funding Future Goals Health Professional Healthcare Systems Heart Arrest Human Subject Research Hypoxia Inflammation Infrastructure Injury Intervention Investigation Leadership Learning Longevity Maine Medical Medical center Mentors Mentorship Methods Molecular Neurological outcome Neurologist Newborn Infant Operative Surgical Procedures Outcome Patient-Focused Outcomes Patients Pharmacists Phase Physicians Pilot Projects Pneumonia Population Preventive Process Protocols documentation Rehabilitation therapy Research Research Infrastructure Research Institute Research Methodology Research Personnel Research Support Resources Resuscitation Risk Rural Rural Community Rural Health Rural Population Scientist Services Signal Transduction Site Standardization Survivors System Technology Telemedicine Testing Time Training Training Support Translational Research Travel United States National Institutes of Health Variant acute care base care delivery care systems career clinical care clinical infrastructure cohesion cohort community engagement community involvement community partnership design disparity reduction diversity and inclusion experience health care disparity health disparity immunoregulation improved improved outcome innovation medical specialties neonatal hypoxic-ischemic brain injury neonate neuroprotection novel novel therapeutics outreach palliative prevent programs prophylactic research study response resuscitative care rural area rural disparities rural health disparities rural patients rurality success survival outcome teleconsent tertiary care tool translational research program trauma care urban area urgent care

项目摘要

Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care and acute care research are pressing, as medical advances have increased the disparities between urban and rural areas. These disparities are due in large part to imbalances in access to specialty-trained clinicians, resources and facilities, as well as clinical research. We propose a new inter-departmental Center for Biomedical Research Excellence (COBRE) at Maine Medical Center, a tertiary care center located in the largest population center (Portland) in the state of Maine. Serving as the hub of activities, this program will mentor cohorts of acute care researchers in significant clinical/translational areas of need while providing a foundation for these studies to impact communities and patients in all regions of our state. This COBRE is led by Douglas Sawyer MD, PhD, an established leader in clinical care services, mentorship, and translational research. The aims of this program are: 1) Provide the leadership, governance, and advisory network to establish a COBRE in Acute Care Research and Rural Disparities at Maine Medical Center; 2) Provide project and mentorship support to launch the careers of promising clinician-scientists within this scientific program, and help ensure their long-term scientific success as independent researchers; 3) Enhance the capabilities of Maine Medical Center's core facilities and research infrastructure to support human subject research of both our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations, and 4) Enhance our existing COBRE- and CTR-supported pilot project programs to focus on translational and clinical opportunities related to acute care and rural health disparities. In Phase I, we have initially selected 4 clinical/translational project leaders with clinical research areas of primary need. These include: Teresa May DO, a critical care physician-researcher developing a standardized statewide system of cardiac arrest post-resuscitation care, David Gagnon PharmD, a pharmacist-researcher testing the benefits of prophylactic antibiotics in cardiac arrest survivors, David Seder MD, a critical care physician-researcher expanding his clinical research program to include translational molecular signaling studies of inflammation in cardiac arrest, and Alexa Craig MD, a pediatric neurologist engaged in research utilizing telemedicine to improve survival and neurological outcomes for newborns born at risk for encephalopathy. These researchers will be supported by a robust mentorship and advisory network and a Community Engagement, Bioethics, and Outreach Core that will develop state-wide health professional and community partnerships in a learning healthcare system to enhance understanding of and increase inclusion in human subjects research.

急性护理研究可以定义为对预防，治愈，康复或姑息治疗的研究取决于时间敏感和紧急干预的行动。因此，急性护理包括多个医疗专业，包括重症监护服务，紧急和紧急护理，创伤和急性护理手术，以及神经关怀。在农村国家，需要改善急性护理和急性护理研究的需求是紧迫，随着医疗进展增加了城市和农村地区之间的差异。这些差异在很大程度上是由于进入专业训练临床医生，资源和设施的失衡，以及临床研究。我们提出了一个新的部门间生物医学研究中心（COBRE）位于缅因州医疗中心，位于最大人口中心（波特兰）的三级护理中心缅因州。作为活动中心，该计划将指导急性护理研究人员在重要的临床/翻译领域，为这些研究提供了基础我们州所有地区的社区和患者。这块毛刺由道格拉斯·索耶（Douglas Sawyer）医学博士领导临床护理服务，指导和翻译研究的领导者。该计划的目的是：1）提供领导，治理和咨询网络来建立急性护理中的毛病缅因州医疗中心的研究和农村差异； 2）提供项目和指导支持以启动这个科学计划中有前途的临床医生的职业，并有助于确保他们的长期作为独立研究人员的科学成功； 3）增强缅因州医疗中心核心的功能设施和研究基础设施，以支持我们的毛病研究人员和其他机构和外部研究人员，刺激创新的研究方法和新的方法合作，以及4）增强我们现有的杂es和CTR支持的试点项目计划，以关注与急性护理和农村健康差异有关的转化和临床机会。在第一阶段，我们有最初选择了具有主要需求的临床研究领域的4位临床/转化项目领导者。这些包括：特雷莎·梅（Teresa May）心脏骤停后护理护理，David Gagnon Pharmd，一名药剂师研究者，测试的好处心脏骤停幸存者的预防性抗生素，大卫·塞德（David Seder）医学博士，重症监护医师研究员扩大他的临床研究计划，包括炎症的翻译分子信号传导研究心脏骤停和Alexa Craig MD，是利用远程医疗研究的研究改善有脑病风险的新生儿的生存和神经结局。这些研究人员将得到强大的指导和咨询网络以及社区参与，生物伦理学以及宣传核心将在学习中发展全州卫生专业和社区伙伴关系医疗保健系统，以增强对人类受试者研究中的理解和增加。