COBRE Center for Sleep and Circadian Rhythms in Child and Adolescent Mental Health

COBRE 儿童和青少年心理健康睡眠和昼夜节律中心

• 批准号: 10090146
• 负责人: Mary A Carskadon
• 金额: $ 203.14万
• 依托单位: EMMA PENDLETON BRADLEY HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-06 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090146
• 关键词: 17q12; Adolescence; Adolescent; Adolescent Psychiatry; Affect; Attention deficit hyperactivity disorder; Behavioral; Career Mobility; Centers of Research Excellence; Characteristics; Child; Child Mental Health; Child Psychiatry; Child Welfare; Childhood; Chronobiology; Circadian Rhythms; Clinical; Cognitive; Collection; Complex; Computer software; Consultations; Copy Number Polymorphism; Core Facility; Country; DNA copy number; DSM-V; Data; Databases; Development; Diagnostic; Doctor of Philosophy; Drowsiness; Early Intervention; Epidemiologist; Evaluation; Faculty; Family; Feeling suicidal; Functional Magnetic Resonance Imaging; Funding; Genes; Goals; Green space; Growth; Health; Heart; Home; Hospitals; Impaired cognition; Incidence; Infrastructure; Institutes; Institution; Laboratories; Leadership; Link; Longevity; Maintenance; Measures; Memory; Mental Health; Mental disorders; Mentors; Mentorship; Methods; Nature; Occupational activity of managing finances; Participant; Pathway interactions; Phenotype; Pilot Projects; Psychiatrist; Psychologist; Research; Research Methodology; Research Personnel; Resources; Rhode Island; Schizophrenia; Schools; Science; Scientist; Seeds; Sleep; Sleep disturbances; Structure; Technology; Training; United States National Institutes of Health; Vulnerable Populations; Work; Youth; autism spectrum disorder; base; career; circadian; circadian pacemaker; clinical care; design; faculty mentor; health assessment; improved; instrumentation; knowledge base; multidisciplinary; neuropsychiatric disorder; neuropsychiatry; neuropsychopharmacology; preventive intervention; programs; psychobiology; recruit; sleep behavior; sleep health; sleep pattern; social; suicidal risk; theories; therapeutic target

PROJECT SUMMARY ABSTRACT This COBRE will establish a Center on Sleep and Circadian Rhythms in Child and Adolescent Mental Health at the EP Bradley Hospital in Rhode Island. Bradley Hospital is unique in the US as a psychiatric institution exclusively focused on children and a national resource for research in child and adolescent psychiatry. Links between mental illness and sleep are indisputable; probing and identifying the links from sleep and circadian rhythms to pediatric mental illness and mental health can identify important pathways to prevention and early intervention, not the least because these factors are amenable to behavioral change and to defined therapeutic targeting. This COBRE aims to build a bridge from the sleep and circadian knowledge base and relevant research methods to the outstanding mental health research and clinical care that characterize Bradley Hospital. The proposed COBRE Center would be the first and only NIH-funded research center to have an explicit focus on sleep, circadian rhythms, and pediatric mental health. The Center will train, mentor, and support junior investigators toward independent research careers. The Center’s research Cores will host training in the assessment of pediatric mental health and in sleep and circadian theory, science, and methods. The objective of this COBRE Center is to establish and build a comprehensive and sustainable resource to support the growth of research in pediatric sleep, circadian rhythms, and mental health while providing mentorship of junior Project Leaders for research and for transitioning to independent scientific careers with external funding. The Center is committed to diversity in faculty, mentors, investigators, research approaches and methods, and research participants. Four promising young investigators have each proposed a project that highlights the diverse and complex nature of this endeavor. Project 1 will measure sleep, circadian timing, and fMRI to assess Self Critical Rumination and Self Reassurance in adolescents at risk for suicidal thoughts and actions. Project 2 evaluates sleep patterns and circadian timing in youth who have a rare DNA copy number variant associated with autism and schizophrenia and includes a circadian clock gene. Project 3 assess in school children (grades 1-3) how green space use impacts sleep and mental health. Project 4 uses an intensive sleep and chronobiology in-lab approach to determine how sleepiness and memory in early adolescents with attention deficit hyperactivity disorder (ADHD) are affected by sleep bioregulatory factors. The ultimate goal of this COBRE is to ease the burden of these issues for children, adolescents, and their families through enhancing the research workforce and capabilities. The promise of this COBRE to fulfill its place as a true center of biomedical research excellence is strong, and the most important, special, and notable aspect of this proposed center is the vulnerable population that forms the heart of our work.

项目摘要摘要 这种毛绒将在儿童和青少年心理上建立一个关于睡眠和昼夜节律的中心 罗德岛州EP Bradley医院的健康状况。布拉德利医院在美国作为精神科是独一无二的 机构专注于儿童和儿童和青少年研究的国家资源 精神病学。精神疾病与睡眠之间的联系是无可争议的；探测和识别来自 睡眠和昼夜节律对小儿精神疾病和心理健康的节奏可以识别出重要的途径 预防和早期干预，并不是最不重要的，因为这些因素可以改变行为改变和 定义治疗靶向。这种毛线旨在从睡眠和昼夜主义知识中建造一座桥梁 杰出的心理健康研究和临床护理的基础和相关研究方法 布拉德利医院的特征。拟议的毛cre中心将是第一个也是唯一的NIH资助研究 中心明确关注睡眠，昼夜节律和小儿心理健康。中心将训练， 导师并支持初级研究人员致力于独立研究职业。中心的研究核心 将在评估小儿心理健康以及睡眠和昼夜节律理论，科学和 方法。这个山脉中心的目的是建立和建立一个全面，可持续的 支持小儿睡眠，昼夜节律和心理健康研究的资源 提供研究和过渡到独立科学的初级项目领导者的精神训练 外部资金的职业。该中心致力于教师，导师，研究人员，研究的多样性 方法和方法以及研究参与者。四个承诺的年轻调查员分别提出了 一个强调这项努力的潜水和复杂性的项目。项目1将测量睡眠， 昼夜节律的时机和fMRI评估自我批判性的反省和自我保证，有风险 自杀思想和行动。项目2评估患有年轻人的睡眠方式和昼夜节律时机 与自闭症和精神分裂症相关的稀有DNA拷贝数变体，包括昼夜节律基因。 项目3的小学生评估（1 - 3年级）如何使用绿色空间会影响睡眠和心理健康。 项目4使用密集的睡眠和计时生物学在LAB方法中来确定嗜睡和记忆力如何 在患有注意力缺陷多动障碍（ADHD）的早期青少年中，睡眠生物调节的影响 因素。这种毛绒的最终目标是减轻儿童，青少年和 他们的家人通过增强研究人员和能力。这个毛茸茸的承诺要实现 它作为真正的生物医学研究中心的位置是强大的，最重要的，特殊和最重要的 这个拟议中心的显着方面是构成我们工作核心的脆弱人群。