Imaging

影像学

• 批准号: 10261017
• 负责人: Bryan William Jones
• 金额: $ 15.75万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261017
• 关键词: Anatomy; Architecture; Area; Award; Basic Science; Biology; Collaborations; Computer software; Data Storage and Retrieval; Databases; Disease; Evolution; Glaucoma; Image; Imagery; Individual; Laboratories; Mathematics; Metabolic; Microscopy; Molecular; Molecular Computations; Normal tissue morphology; Optics; Research; Research Personnel; Research Project Grants; Resources; Retinal Degeneration; Scanning; Schools; Services; Silicon; Software Tools; Speed; System; Technical Expertise; Tissues; Training; Translational Research; Universities; Utah; Vision research; Visual system structure; base; confocal imaging; developmental disease; experience; large scale data; metabolomics; molecular phenotype; novel; operation; optical imaging; petabyte; software repository; statistics; web app; working group

Project Summary-Imaging Core The OVERALL aims of this Vision Research Core (VRC) are to provide: · access to resources outside the scope of individual R01 awards · access to technical expertise outside the scope a single laboratory · staff training to remove barriers to efficient translational research and collaboration · collaboration initiatives among VRC labs The research areas supported by the VRC span the analysis of fundamental biology of normal tissues involved in the visual system as well as a range of cutting-edge basic science initiatives involved in treatments of retinal degenerations, developmental disorders, glaucoma and other disorders. We have implemented four resource modules that continue the natural evolution of how this research group works together, serving 17 investigators holding 22 NEI R01 awards. The Imaging Module provides a range of imaging (TEM, confocal, metabolomic CMP, scanning optical) and computing services (imaging, database, mathematics) based on strengths of core laboratories and the tradition of excellence of the UU School of Computing, whose descendants founded Adobe Systems, Silicon Graphics, Netscape and Pixar. Collaborations among these groups have transformed software tools for TEM and confocal imaging. Specifically, the Imaging Module provides: • novel, powerful high-speed automated TEM for VRC investigators, regardless of experience, that delivers top quality TEM imagery in a readily navigable format using the Viking web-application. • metabolic mapping onto anatomy using Computational Molecular Phenotyping (CMP) resources. • research grade confocal resources and management both in the JMEC proper and the JMEC vivarium; expanded confocal resources are planned. • high-speed optical scanning microscopy for high-throughput tissue / immunocytochemical analysis. • extensive imaging, database and mathematics software holdings and training expertise • large scale data storage for the VRC (up to 0.5 petabyte).

项目摘要成像核心 该愿景研究核心（VRC）的总体目标是提供： ·访问个人R01奖项范围之外的资源 ·范围外的技术专长访问一个实验室 员工培训以消除有效的转化研究和协作的障碍 VRC实验室之间的合作计划 VRC支持的研究领域跨越了涉及正常组织的基本生物学的分析 在视觉系统以及一系列涉及残留治疗的尖端基础科学计划 退化，发育障碍，青光眼和其他疾病。我们已经实施了四个资源 该研究小组如何共同运作的模块，为17位研究人员提供服务 获得22个NEI R01奖项。 成像模块提供了一系列成像（TEM，共焦，代谢组CMP，扫描光学）和 基于核心实验室的优势和传统的计算服务（成像，数据库，数学） UU计算学院的卓越表现，其后代创立了Adobe系统，硅图形， Netscape和Pixar。这些小组之间的合作已为TEM和 共聚焦成像。 具体而言，成像模块提供： •无论经验如何 使用Viking Web应用程序以易于导航格式提供高质量的TEM图像。 •使用计算分子表型（CMP）资源的代谢映射到解剖结构。 •研究等级的共焦资源和管理均在JMEC PORPOR和JMEC VIVARIUM中； 计划扩大共聚焦资源。 •用于高通量组织 /免疫细胞化学分析的高速光学扫描显微镜。 •广泛的成像，数据库和数学软件持有和培训专业知识 •VRC的大规模数据存储（最高0.5 pB）。