1/2 CCNY-MSKCC Partnership for Cancer Research, Education and Community Outreach

1/2 CCNY-MSKCC 癌症研究、教育和社区外展合作伙伴关系

基本信息

批准号：
10260492
负责人：
Tim Alan Ahles
金额：
$ 151.7万
依托单位：
CITY COLLEGE OF NEW YORK
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-26 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10260492
关键词：
Address Affect African American Area Award Biomedical Engineering Bone neoplasms Breast Cancer Early Detection Cancer Research Project Cell Line Cellular biology Certification Cities Clinical Collaborations Communities Community Health Aides Community Networks Community Outreach Computers Data Deuterium Oxide Development Drug Delivery Systems Education Education and Outreach Elderly Engineering Environment Funding Future Genome Stability Goals Grant Human Papilloma Virus Vaccination Human Papilloma Virus Vaccine Human Resources Image Immersion Immunoglobulin Genes Immunology Institution Institutional Policy Intervention Label Latino Linguistics Low income Malignant Neoplasms Measures Mechanics Medical Medical Computer Science Medical Imaging Memorial Sloan-Kettering Cancer Center Mentorship Minority Modeling Multilingualism New York Obesity Pilot Projects Policies Population Heterogeneity Populations at Risk Positioning Attribute Raman Spectrum Analysis Recording of previous events Research Research Activity Research Personnel Resource Sharing Resources Risk Factors Risk Reduction Role Schools Scientist Series Students Testing Training Translational Research Translations Underrepresented Minority United States Health Resources and Services Administration Universities Woman anticancer research cancer care cancer cell cancer clinical trial cancer education cancer health disparity cancer risk cancer subtypes career clinical care college colorectal cancer screening community engaged research disparity reduction education research experience health disparity high risk improved innovation interest low socioeconomic status medical schools medically underserved molecular imaging multiphoton microscopy outreach pedagogy post-doctoral training programs screening socioeconomics success translational cancer research translational medicine tumor underrepresented minority student underserved community working group

项目摘要

The CCNY-MSKCC Partnership has successfully created a mutually beneficial, cross-institutional collaboration that has emphasized research across the translational continuum, the creation of an education pipeline for attracting minority and low-income students to careers in cancer research, and the establishment of community networks and resources for conducting linguistically and culturally-responsive community engaged research among diverse, at-risk populations. Over the last five years, areas of particular strength have been developed, including: 1) rich collaborations between engineers and computer scientists at CCNY and clinicians and imaging experts at MSKCC to develop innovative solutions to improve cancer care, and 2) sustainable, translational health disparities research and activities that directly benefit underserved communities in New York, and serve as national models in terms of: a) screening / identification of cancer risk factors that disproportionately affect minorities; b) socioeconomic determinants of access to, and successful completion of, treatment; and c) policy change. Consistent with these areas of emphases, we propose two full projects that focus on: 1) Tumor ensemble models to predict tumor dormancy and reactivation and testing how these models perform across various ethnic cell lines, e.g., triple negative tumors that disproportionately affect African American women and 2) Characterizing the Role of ATM in Immunoglobulin Gene Diversification and Genome Stability. Two proposed pilot projects include: 1) Raman spectroscopy with heavy water labeling and multiphoton microscopy to allow early detection of breast cancer subtypes, including triple negative cancers and 2) Development of Mechanical Interventions to Enhance Drug Delivery to Bone Tumors. New innovative Partnership components include: 1) development of the Linguistic and Cultural Responsiveness Shared Resource Core; 2) formation of the Engineering Health Disparities working group; and 3) new educational programs including the Scholars for the Future program and the Certificate for Medical Translation and Interpretation. The Partnership specific aims are to: 1) Continue to develop outstanding cancer research programs in health disparities, biomedical engineering, computer science / medical imaging, cancer cell biology, and immunology along the Translational Research Continuum; 2) collaborate with diverse communities to conduct and facilitate trailblazing cancer disparities research, and outreach, education, risk reduction, and navigation activities to define and address cancer disparities, with the goal of improving cancer care in the large, medically underserved local and national communities; 3) continue to develop and expand educational opportunities in a robust translational cancer research environment to attract and retain students interested in cancer research (particularly minority and low income students); these opportunities will be enhanced by educational opportunities and increased mentorship and support; and 4) expand and integrate the personnel, resources, and environment needed for scientific collaboration across institutions and influence institutional policies in support of this objective.

CCNY-MSKCC 合作伙伴关系成功建立了互惠互利的跨机构合作强调跨转化连续体的研究，为以下领域创建教育渠道：吸引少数族裔和低收入学生从事癌症研究职业，并建立社区用于进行语言和文化响应的社区参与研究的网络和资源在不同的高危人群中。在过去的五年里，特别有优势的领域得到了发展，包括：1) CCNY 的工程师和计算机科学家与临床医生和影像学之间的丰富合作 MSKCC 的专家开发创新解决方案来改善癌症护理，以及 2) 可持续的、转化性的健康差异研究和活动直接使纽约服务不足的社区受益，并服务于作为以下方面的国家模式：a) 筛查/识别不成比例影响的癌症风险因素少数民族； b) 获得和成功完成治疗的社会经济决定因素； c) 政策改变。与这些重点领域一致，我们提出了两个完整的项目，重点关注：1）肿瘤集成模型来预测肿瘤休眠和重新激活，并测试这些模型在跨领域的表现各种种族细胞系，例如，不成比例地影响非裔美国妇女的三阴性肿瘤 2) 表征 ATM 在免疫球蛋白基因多样化和基因组稳定性中的作用。两个提议试点项目包括： 1) 具有重水标记和多光子显微镜的拉曼光谱，以允许乳腺癌亚型的早期检测，包括三阴性癌症以及 2) 机械技术的发展增强骨肿瘤药物输送的干预措施。新的创新合作伙伴关系组成部分包括：1) 开发语言和文化响应共享资源核心； 2) 的形成工程健康差异工作组； 3）新的教育计划，包括学者未来的计划和医学翻译和口译证书。该伙伴关系的具体目标是 1) 继续在健康差异、生物医学等领域开发杰出的癌症研究项目工程、计算机科学/医学成像、癌细胞生物学和免疫学转化研究连续体； 2）与不同社区合作进行和促进开拓癌症差异研究以及外展、教育、降低风险和导航活动，以定义和解决癌症差异，目标是改善医疗服务不足的大型地区和地区的癌症护理民族社区； 3）继续以稳健的转化方式发展和扩大教育机会癌症研究环境，以吸引和留住对癌症研究感兴趣的学生（特别是少数族裔）和低收入学生）；这些机会将通过教育机会和增加而得到加强指导和支持； 4）扩大和整合所需的人员、资源和环境跨机构的科学合作并影响支持这一目标的机构政策。