Assessment of sensory gating, attention, and executive control in breast cancer

乳腺癌感觉门控、注意力和执行控制的评估

• 批准号: 10312035
• 负责人: Tim Alan Ahles
• 金额: $ 68.12万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312035
• 关键词: Address; Adjuvant; Affect; Aftercare; Appearance; Area; Attention; Behavioral; Brain; Breast Cancer Patient; Breast Cancer Treatment; Cancer Patient; Cancer Survivor; Clinical; Cognition; Cognitive; Delayed Memory; Enrollment; Equipment and supply inventories; Exposure to; Goals; High Prevalence; Impaired cognition; Impairment; Intervention; Learning; Longitudinal Studies; Measurement; Measures; Memory; Memory impairment; Methods; Neuropsychological Tests; Neuropsychology; Neurosciences; Normal Range; Oncologist; Patient Self-Report; Patients; Perception; Performance; Postmenopause; Preparation; Prevalence; Preventive treatment; Process; Psychologist; Psychophysiology; Reporting; Research; Schizophrenia; Sensory; Structure; Survivors; Syndrome; Techniques; Testing; Time; Treatment-Related Cancer; United States National Institutes of Health; Volition; Woman; Work; attentional control; base; cancer therapy; chemotherapy; clinically relevant; cognitive change; cognitive development; cognitive function; cognitive neuroscience; cognitive process; executive function; forgetting; improved; inattention; individualized medicine; information processing; innovation; malignant breast neoplasm; novel strategies; performance based measurement; processing speed; prospective; response; sensory gating; stimulus processing; theories

ABSTRACT Despite significant progress in understanding cancer and cancer-treatment associated cognitive dysfunction (CACD), concerns have been raised about the adequacy of traditional neuropsychological tests to accurately detect cognitive changes reported by patients. Memory deficits are the most commonly reported cognitive problems among survivors; however, assessment with traditional neuropsychological measures of memory has frequently demonstrated performance in the normal range. We propose that changes in attentional processes interfere with efficient and effective encoding of information in memory. Therefore, survivors’ perception of memory problems is accurate, but related to deficits in attention rather than memory. Traditional neuropsychological measures: 1) Can have low test-retest reliability over clinically relevant timeframes leading to large measurement error; 2) Focus on coarsely defined domains of cognitive function while ignoring the subcomponents of attention critical for later recall; 3) Are unable to measure pre-attentive processes like sensory gating / filtering; and 4) Do not correlate with self-report of cognitive problems. To address these limitations, we have developed a battery of well-studied and validated cognitive experimental measures, the Sensory-Attention-Executive (SAE) battery, which will allow for decomposition of sensory, attentional and executive sub-processes that underlie efficient learning and encoding of information. We will examine cognitive changes associated with adjuvant treatment for postmenopausal breast cancer patients treated with chemotherapy (CT+: N=100) and not treated with chemotherapy (CT-: N=100), who will be assessed prior to adjuvant treatment, 1 month post-chemotherapy (yoked for CT- patients) and 12 and 24 months post- enrollment with the SAE battery and traditional neuropsychological measures. Matched healthy controls (N=100) will be assessed over similar timeframes. The objective of this proposal is to evaluate the following specific aims: Aim 1: Examine alterations in subcomponents of attention and executive control using the SAE battery at pretreatment and over time in CT+ and CT- compared to matched, healthy controls; Aim 2: Examine the prevalence of impairment at pretreatment and over time utilizing the SAE battery versus traditional neuropsychological measures in CT+ and CT- compared to matched, healthy controls; Aim 3: Examine the relationship of measures of pre-attentive processing to later, performance-based measures of attention and memory from the SAE and traditional batteries; and Aim 4: Examine associations between self-report measures (Sensory Gating Inventory and FACT-Cog) and performance on the SAE battery and traditional neuropsychological measures. This research is significant because use of the SAE measures could more precisely identify subcomponents of cognitive processes associated with CACD leading to tailored treatments and is innovative because it utilizes assessments base on cognitive neuroscience allowing for assessment of subcomponent cognitive processes along the information processing chain, including pre-attentive processes.

抽象的 尽管在理解癌症和癌症治疗方面取得了重大进展 （CACD），人们对传统神经心理学测试的适当性提出了担忧 检测患者报告的认知变化。记忆定义是最常见的认知 生存问题；但是，通过传统神经心理学记忆的评估具有 经常在正常范围内表现出表现。我们提出注意力过程的变化 干扰内存中信息的有效编码。因此，生存的看法 记忆问题是准确的，但与定义注意力而不是记忆有关。传统的 神经心理学措施：1）在临床相关时间表上可以具有低测试可靠性 大量测量误差； 2）专注于认知功能的粗糙定义域，同时忽略 关注的子组件对于以后的召回至关重要； 3）无法衡量像 感觉门控 /过滤； 4）与认知问题的自我报告无关。解决这些 局限性，我们开发了一系列经过深入验证和验证的认知实验措施， 感官注意连续的（SAE）电池，这将允许感官，注意力和 高效学习和信息编码是执行子过程。我们将检查 与经过治疗的绝经后乳腺癌患者的调整治疗相关的认知变化 化学疗法（CT+：n = 100），未接受化学疗法治疗（CT-：n = 100），将在之前进行评估 辅助治疗，化学疗法后1个月（针对CT患者的YOK）和12个月和24个月 SAE电池和传统神经心理学措施的注册。匹配的健康对照 （n = 100）将在相似的时间表上进行评估。该提议的目的是评估以下 具体目的：目标1：使用SAE检查注意力和执行控制的子组成部分的变化 与匹配，健康对照相比，预处理和随着时间的推移在CT+和CT-中进行了电池；目标2：检查 在预处理和使用SAE电池与传统的情况下，损害的患病率和随着时间的流逝 与匹配，健康对照相比，CT+和CT-的神经心理学措施；目标3：检查 竞争前处理的测量与以后的，基于绩效的注意力的测量和 SAE和传统电池的记忆；目标4：检查自我报告之间的关联 SAE电池和传统 神经心理学措施。这项研究很重要，因为使用SAE测量可能会更多 精确识别与CACD相关的认知过程的子组成部分，导致量身定制的治疗 并且具有创新性，因为它利用了认知神经科学的评估，允许评估 沿着信息处理链的子组件认知过程，包括集中的过程。

项目成果

The effect of visual target presence and age on antisaccade performance.

视觉目标存在和年龄对抗眼跳性能的影响。

• DOI: 10.1152/jn.00186.2022
• 发表时间: 2023
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Edelman,JayA;Ahles,TimA;Prashad,Neelam;Fernbach,Madalyn;Li,Yuelin;Melara,RobertD;Root,JamesC
• 通讯作者: Root,JamesC