Yoga and Cardiovascular Disease Risk in Older Women

老年女性的瑜伽和心血管疾病风险

• 批准号: 7558547
• 负责人: KAREN-KIM E INNES
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7558547
• 关键词: Applications Grants; Area; Award; Behavior Therapy; Behavioral Medicine; Biology; Cardiovascular Diseases; Cause of Death; Chronic; Chronic Disease; Clinical; Comorbidity; Coupled; Discipline; Disease; Educational workshop; Epidemiologist; Fellowship; Goals; Health Care Costs; Insulin Resistance; Intervention; Intervention Studies; K-Series Research Career Programs; Lead; Menopause; Metabolic; Methods; Mind-Body Intervention; Non-Insulin-Dependent Diabetes Mellitus; Overweight; Physiology; Pilot Projects; Population; Postmenopause; Prevention; Productivity; Prophylactic treatment; Randomized; Research; Research Personnel; Research Training; Risk Factors; Risk Reduction; Solid; Stress; Syndrome; Therapeutic Intervention; Training; Training Programs; Woman; Women' s Health; Yoga; base; body-mind; cardiovascular disorder risk; cost; design; diabetic; experience; indexing; insulin sensitivity; meetings; non-diabetic; older women; programs; psychologic; sedentary; skills; skills training

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) remains the leading cause of death in women. CVD risk rises sharply with menopause and is further elevated among women with type 2 diabetes (DM 2). These increases are likely due to the coincident rise in insulin resistance and other, related atherogenic changes comprising the insulin resistance syndrome (IRS). There is growing evidence that the practice of yoga may offer a safe and cost-effective strategy for reducing IRS-related risk factors for CVD in both diabetic and non-diabetic populations. However, rigorous studies are few. The proposed K-01 award will provide the necessary training, skills, and experience for Dr. Kim Innes, an epidemiologist with a strong background in women's health and chronic disease and recent fellowship training in CAM, to conduct clinical intervention research regarding the effects of yoga on CVD risk reduction in women. Her long-term goal is to establish a successful research program investigating yoga for the prevention and management of CVD and related chronic, insulin resistance conditions. Immediate goals toward this end are, through a rigorous program of didactic training and research, to: 1) gain additional expertise in advanced quantitative methods, chronic disease physiology, and stress biology; 2) develop a solid practical and theoretical background in the field of mind-body and behavioral medicine, with a focus on yoga therapy; and 3) strengthen her skills in clinical intervention research and gain needed experience in behavioral intervention studies involving mind-body therapies. The candidate has assembled an exceptional sponsoring committee of investigators with extensive expertise in each of these disciplines, who will guide her activities and progress throughout the award period. The training program will include regular meetings with the lead sponsor and co-sponsors, coupled with participation in selected courses, tutorials, workshops, seminars, professional meetings and research practica relevant to Dr. lnnes's area of research. Dr. Innes will execute two pilot studies that will comprise the focus of the K award and the basis for at least two subsequent RO1 grant applications to be submitted within the award period. Using a randomized controlled design, these pilot studies will investigate the effects of a gentle 8-week lyengar yoga program on insulin sensitivity and related metabolic and psychological indices of CVD risk in two populations at elevated risk for CVD: sedentary, overweight postmenopausal women who are currently healthy and postmenopausal women with DM 2. The proposed studies will yield important information on the potential utility of a safe, inexpensive intervention in reducing CVD risk in both diabetic and healthy women postmenopause. If findings are positive and confirmed in other, larger studies, the use of yoga as a therapeutic intervention and prevention measure for CVD and related comorbidities could potentially save billions of dollars in health care costs and lost productivity due to these disorders.

描述（由申请人提供）：心血管疾病（CVD）仍然是女性死亡的主要原因。 CVD 风险随着更年期急剧上升，并且在患有 2 型糖尿病 (DM 2) 的女性中进一步升高。这些增加可能是由于胰岛素抵抗和其他相关的动脉粥样硬化变化（包括胰岛素抵抗综合征（IRS））同时增加所致。越来越多的证据表明，瑜伽练习可以提供一种安全且具有成本效益的策略，以减少糖尿病和非糖尿病人群中与 IRS 相关的 CVD 危险因素。然而，严格的研究却很少。拟议的 K-01 奖项将为 Kim Innes 博士提供必要的培训、技能和经验，Kim Innes 博士是一位流行病学家，在妇女健康和慢性病方面拥有丰富的背景，最近在 CAM 进行了进修培训，以开展有关以下因素影响的临床干预研究：瑜伽有助于降低女性心血管疾病风险。她的长期目标是建立一个成功的研究计划 研究瑜伽对心血管疾病和相关慢性胰岛素抵抗疾病的预防和管理。实现这一目标的直接目标是通过严格的教学培训计划和 研究，以：1）获得先进定量方法、慢性病生理学和应激生物学方面的额外专业知识； 2）在身心领域发展扎实的实践和理论背景 行为医学，重点是瑜伽疗法； 3）加强她的临床干预技能 研究并获得涉及身心疗法的行为干预研究所需的经验。候选人组建了一个由在每个学科拥有丰富专业知识的研究人员组成的杰出赞助委员会，他们将在整个奖励期间指导她的活动和进展。培训计划将包括与主要赞助商和共同赞助商的定期会议，以及参加与 lnnes 博士研究领域相关的选定课程、教程、讲习班、研讨会、专业会议和研究实践。 Innes 博士将执行两项试点研究，其中包括 K 奖的重点以及在奖励期内提交的至少两项后续 RO1 资助申请的基础。这些试点研究采用随机对照设计，将调查为期 8 周的莱恩格瑜伽项目对两个 CVD 风险较高人群的胰岛素敏感性以及 CVD 风险相关代谢和心理指标的影响：久坐、体重超重的绝经后女性。目前患有 DM 2 的健康和绝经后女性。拟议的研究将提供重要信息，说明安全、廉价的干预措施在降低糖尿病和健康绝经后女性的 CVD 风险方面的潜在效用。如果研究结果是积极的，并在其他更大规模的研究中得到证实，那么使用瑜伽作为心血管疾病和相关合并症的治疗干预和预防措施，可能会节省数十亿美元的医疗保健费用，并减少因这些疾病而造成的生产力损失。