System to Track Samples in Liquid Nitrogen Environment

液氮环境中样品追踪系统

• 批准号: 10261001
• 负责人: Hanan Davidowitz
• 金额: $ 82.14万
• 依托单位: BIO TILLION, LLC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261001
• 关键词: Adopted; Biological; Cold Chains; Communities; Computer software; Databases; Electronics; Elements; Embryo; Environment; Equipment and supply inventories; Freezing; Goals; Human; Human Resources; Individual; Label; Liquid substance; Location; Manuals; Maps; Mechanics; Medical; Memory; Methods; Nitrogen; Phase; Price; Records; Regenerative Medicine; Research; Retrieval; Risk; Robotics; Sampling; Small Business Innovation Research Grant; Study Section; System; Technology; Temperature; Testing; Time; Update; Vial device; Work; Writing; base; cost; design; feasibility testing; graphical user interface; human error; internal control; prototype; robotic system; success

Today, there are primarily two ways to track samples in a liquid nitrogen freezer, manual methods and robotic systems. Manual tracking is by far the most common method today but it is prone to human error since samples can be misplaced, entries can be inaccurate, samples can be moved, removed, or added without accurately updating the database. Robotic freezers, on the other hand, keep accurate records but they (a) are very expensive, and (b) their capacity is significantly reduced due to the robotics. The goal of this SBIR fast-track proposal, is to develop a functional prototype of a system that will allow real-time box tracking in a liquid nitrogen freezer. It will perform inventories without even opening the freezer. It will guide the users to the desired sample boxes for retrieval and alert them to errors (and how to correct them) when they occur. When used with our liquid nitrogen temperature box mapper a cold chain of custody from multiple freezers down to individual sample vials can be maintained and documented. This system will afford many of the benefits of a robotic system at about 10% of the price and without sacrificing any freezer space at all. This system will capture the very large segment of the market between single freezers with handwritten notebooks and Excel spreadsheets on the one hand, and expensive robotic freezer systems on the other. New electronics that is compatible with the challenging liquid nitrogen environment and the associated low level software will need to be developed but other elements of the system such as the user interface can be adapted from BioTillion‘s existing products. To mitigate risk, we have already identified and tested individual electronics components that function at -196 °C. The goal of the Phase I will be to design, fabricate and test (a) prototypes of the electronic designs needed to read RFID box tags at -196 °C and (b) RFID tagged labels that can be read at liquid nitrogen temperatures. The goal of the Phase II will be to use the Phase I results to develop a fully functional prototype of our system that will operate in a liquid nitrogen freezer.

如今，有两种方法可以跟踪液氮冰柜中的样品，手动方法和机器人 系统。到目前为止，手动跟踪是当今最常见的方法 样本可能放错位置，条目可能不准确，可以移动，删除或添加样品，而无需添加 准确更新数据库。 另一方面，机器人冰柜保持准确的记录，但（a）非常昂贵，（b） 由于机器人技术，容量大大降低。 该SBIR快速轨道建议的目标是开发系统的功能原型，该原型将允许实时 液体氮冷冻室中的盒子跟踪。它将执行库存，甚至不打开冰柜。 将引导用户进入所需的样品框以进行检索，并提醒他们错误（以及如何更正 他们）当他们发生时。 当与我们的液体氮温度盒映射器一起使用时 可以维护和记录到单个样品小瓶。 该系统将在机器人系统价格上以大约10％的价格和没有 牺牲任何冷冻空间。 该系统将通过 一方面手写笔记本和Excel电子表格，以及昂贵的机器人冷冻系统 其他。 与挑战液氮环境兼容的新电子产品和相关的低 级别软件将需要开发，但是系统的其他元素，例如用户界面 改编自Biotillion现有产品。为了减轻风险，我们已经确定并测试了个人 在-196°C下起作用的电子组件。 I阶段的目的是设计，制造和测试（a）所需的电子设计原型 在-196°C和（b）可以在液氮温度下读取的RFID框标签。 第二阶段的目的是使用I阶段结果来开发系统的功能性原型 这将在液氮冷冻室中运行。