Increasing Animal Foods in Diets of HIV-Infected Kenyan Women and Their Children

增加感染艾滋病毒的肯尼亚妇女及其儿童饮食中的动物性食品

• 批准号: 7897603
• 负责人: Judith A Ernst
• 金额: $ 33.46万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7897603
• 关键词: Acquired Immunodeficiency Syndrome; Adherence; Affect; Africa South of the Sahara; Age; Animal Feed; Animal Sources; Anthropometry; Anti-Retroviral Agents; Area; Biological Availability; Body Composition; CD4 Positive T Lymphocytes; Caring; Child; Clinic; Clinical; Control Groups; Development; Diet; Dietary Intervention; Eating; Effectiveness; Enrollment; Evaluation; Fingers; Food; Goals; Growth and Development function; HIV; Hand; Health; Human; Immune system; Immunologic Deficiency Syndromes; Individual; Infant; Infection; Intake; Intervention; Iron; Isotopes; Kenya; Life; Lysine; Maintenance; Malnutrition; Mastication; Measures; Meat; Metabolic; Methodology; Methods; Micronutrients; Monitor; Muscle; Nutrient; Nutritional; Opportunistic Infections; Outcome; Outcomes Research; Patients; Pharmaceutical Preparations; Pharmacotherapy; Population; Proteins; Quality of life; Randomized; Randomized Clinical Trials; Research; Resistance; Role; Rural; Sampling; Skin; Solutions; Southern Africa; Supplementation; Testing; Tissues; Triceps Brachii Muscle; Virus Diseases; Vitamin B 12; Water; Weight Gain; Wheat; Woman; Zinc; arm; base; experience; feeding; functional outcomes; grasp; immune function; improved; innovation; mortality; nutrition; prevent; reproductive; tool

DESCRIPTION (provided by applicant): In the proposed project we will evaluate the effect of protein and micronutrients in meat on the health and nutritional well being of rural Kenyan women living with HIV and the health and development of their children, by means of a randomized nutrition intervention. Our long- term goal is to determine if a "right mix" of food, that is sustainable, will protect the immune system, prevent severe infection and loss of body mass and enhance the quality of life of HIV-infected rural Kenyan women who are not yet experiencing nutritional and metabolic challenges associated with advanced HIV infection as well as protect the growth and development of their children who are certainly affected and may be infected from HIV. Our central hypothesis is that drug na¿ve HIV-infected women and their HIV negative (affected) children and their HIV-infected children in rural Kenya, provided a meat derived supplement, have improved nutritional and clinical outcomes, growth and development in children and ability to carry out tasks of daily living in women compared to those given isocaloric soya supplements and those in a control group. We plan to test our central hypothesis and accomplish the overall objective of the application by pursuing the following specific aims that will provide a comprehensive assessment of the impact of meat. Specific aim #1: Measure the impact of a meat supplements on overall health, micronutrient status, body composition and progression of infection in drug na¿ve HIV- infected Kenyan women and their children in a rural setting in Western Kenya. Our hypothesis is that meat in the diet, possibly due to the amounts of lysine and vitamin B12 and the enhanced bioavailability of iron and zinc, results in improved clinical outcomes, B weight gain, lean body mass, resistance to opportunistic infections, growth and development in children and ability to carry out normal tasks of daily living in women. We will accomplish this aim by means of a randomized clinical trial in which we compare the effect of a meat based supplement vs. isocaloric soya and wheat based supplements. Specific aim #2: Contribute to improved monitoring of changes in body composition and strength of HIV-infected women and children in field settings in rural Kenya. Our hypothesis is that accurate estimates of lean body mass and strength in HIV- infected women and children can be easily obtained in field settings in rural Kenya. We will accomplish this aim by comparing bioimpedance (BIA) methodology and hand grip and finger pinch dynamometry measures with arm muscle area calculated from triceps skin fold and mid- arm circumference measures. Methodologies (BIA and anthropometry) will be validated with isotope dilution (2H2O) in a sub-sample of the enrolled drug na¿ve HIV-infected Kenyan women.

描述（由申请人提供）：在拟议的项目中，我们将通过随机研究的方式，评估肉类中的蛋白质和微量营养素对感染艾滋病毒的肯尼亚农村妇女的健康和营养状况及其子女的健康和发育的影响。我们的长期目标是确定可持续的“正确的食物组合”是否能够保护免疫系统，防止严重感染和体重减轻，并提高感染艾滋病毒的肯尼亚农村人的生活质量。尚未经历过的女性与晚期艾滋病毒感染相关的营养和代谢挑战，以及保护肯定受到艾滋病毒影响和可能感染艾滋病毒的孩子的生长和发育。肯尼亚农村地区的 5 名艾滋病毒感染妇女及其艾滋病毒呈阴性（受影响）的儿童及其感染艾滋病毒的儿童获得了肉类补充剂，改善了营养和临床结果、儿童的生长和发育以及执行日常生活任务的能力与服用等热量大豆补充剂的女性和对照组的女性相比，我们计划测试我们的中心假设，并通过追求以下具体目标来实现应用的总体目标，这些目标将对肉类的影响进行全面评估。目标#1：衡量肉类补充剂对整体健康、微量营养素状况、身体成分和药物感染进展的影响肯尼亚西部农村地区有 5 名感染艾滋病毒的肯尼亚妇女及其子女，我们的假设是，饮食中的肉类可能会改善临床结果，这可能是由于赖氨酸和维生素 B12 的含量以及铁和锌的生物利用度的提高。 ，B 体重增加、去脂体重、对机会性感染的抵抗力、儿童的生长和发育以及女性执行正常日常生活任务的能力我们将通过随机临床试验来实现这一目标，在该试验中我们比较效果。以肉类为基础的具体目标#2：有助于改善对肯尼亚农村地区感染艾滋病毒的妇女和儿童的身体成分和体力变化的监测。在肯尼亚农村的现场环境中，可以轻松获得艾滋病毒感染妇女和儿童的力量和力量。我们将通过比较生物阻抗（BIA）方法、握力和手指捏力测量值与根据三头肌计算的手臂肌肉面积来实现这一目标。皮肤褶皱和中臂周长测量方法（BIA 和人体测量）将在登记药物的子样本中通过同位素稀释 (2H2O) 进行验证。 ve 感染艾滋病毒的肯尼亚妇女。