Tissue Management Shared Resource

组织管理共享资源

• 批准号: 10260741
• 负责人: Adam Yopp
• 金额: $ 57.05万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260741
• 关键词: African American; Anatomy; Biological Markers; Bladder; Blood; Bone Marrow; Breast; Cancer Center; Cancer Center Support Grant; Caucasians; Clinical; Clinical Cancer Center; Clinical Data; Clinical Research; Clinical and Translational Science Awards; Colon; Computerized Medical Record; Consent; Data; Data Collection; Database Management Systems; Databases; Development; Disease; Environment; Equipment; Female; Genetic; Genetic Databases; Genomics; Goals; Growth; Hispanics; Human; Infrastructure; Institutional Review Boards; Ischemia; Kidney; Laboratory Finding; Link; Liquid substance; Location; Lung; Malignant Neoplasms; Medical center; Monitor; Pancreas; Participant; Pathologic; Pathology; Pleural; Prostate; Proteins; Proteomics; Protocols documentation; Reaction; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Sampling; Secure; Services; Specimen; Technology; Time; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Universities; Update; Urine; Validation; base; biomarker panel; cancer type; central database; data warehouse; database query; demographics; innovation; interest; member; metabolomics; outcome forecast; tool; translational medicine; tumor; tumor registry; web interface

Harold C. Simmons Cancer Center Tissue Management Shared Resource (Translational Research Resource) Project Summary/Abstract The Tissue Management Shared Resource was established in 2004 to provide IRB-approved centralized tissue procurement services for specimens derived from consented human participants. Over 22,000 tissue specimens and bodily fluids, from over 50 different tissue types including breast, lung, prostate, kidney, bladder, colon, pancreas, blood, pleural fluid, urine and bone marrow have been collected since its establishment. In terms of demographics, specimens were obtained from Caucasian (72%), African-American (24%) and Hispanic participants (16%). Of the tissues collected, 56% of specimens are derived from female participants. Although the basic functions and goals of the Tissue Management Shared Resource remain essentially unchanged, the capabilities of the facility have been significantly expanded to support the growing needs of Simmons Cancer Center members and facilitate translational research activities. To facilitate this growth, Tissue Management Shared Resource has moved to a new location that provides additional space for equipment and staff. The equipment has been updated to accommodate increased and changing research needs. Additionally, tissue banking and annotation of specimens has been extensively expanded. Specimen related data are captured and stored in our tissue management database, caTissue Plus, and are correlated with clinical information through the Simmons Cancer Center's clinical research data warehouse (i2b2) as part of the UTSW Center for Translational Medicine (CTM), which is the institutional CTSA (Clinical & Translational Science Award). This tool links caTissue Plus data with EPIC Clarity (the electronic medical record), Oncolog (the university tumor registry database), CoPath (the anatomical pathology database), CancerGeneConnect (the familial genetics database) and other disease-specific databases. Due to this robust infrastructure, biospecimens are automatically annotated with demographic, pathological, and clinical data so that interested investigators can perform basic sample availability queries of this database in a de-identified manner through a secure web interface.

Harold C. Simmons癌症中心 组织管理共享资源（转化研究资源） 项目摘要/摘要 组织管理共享资源于2004年建立，以提供IRB批准的集中式 来自同意的人参与者的标本的组织采购服务。超过22,000张组织 来自50多种不同组织类型的标本和体液，包括乳房，肺，前列腺，肾脏， 自膀胱，结肠，胰腺，血液，胸膜液，尿液和骨髓以来已被收集 建立。在人口统计学方面，标本是从白种人（72％），非裔美国人获得的 （24％）和西班牙裔参与者（16％）。在收集的组织中，有56％的标本源自雌性 参与者。尽管组织管理的基本功能和目标共享资源仍然存在 本质上是没有变化的，该设施的功能已大大扩展以支持增长 西蒙斯癌症中心成员的需求并促进转化研究活动。促进这一点 增长，组织管理共享资源已转移到新的位置，为 设备和员工。该设备已更新以适应增加和不断变化的研究 需要。此外，标本的组织库和注释已广泛扩展。标本 相关数据被捕获并存储在我们的组织管理数据库，Catissue Plus中，并相关 通过Simmons癌症中心的临床研究数据仓库（I2B2）提供临床信息。 UTSW转化医学中心（CTM）是机构CTSA（临床和转化 科学奖）。该工具将Catissue加数据与史诗般的清晰度（电子病历）链接 （大学肿瘤登记数据库），COPATH（解剖病理数据库），癌症连接 （家族遗传学数据库）和其他特定疾病的数据库。由于这种强大的基础架构， 生物测量自动用人口统计，病理和临床数据自动注释，以便感兴趣 调查人员可以通过否定的方式对此数据库进行基本样本可用性查询 安全网络界面。