Tissue Management Shared Resource

组织管理共享资源

• 批准号: 10693250
• 负责人: Adam Yopp
• 金额: $ 40.1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10693250
• 关键词: Academia; Animal Model; Asian; Biological Markers; Black race; Bladder; Blood; Blood specimen; Body Fluids; Bone Marrow; Breast; Cancer Center Support Grant; Cell Culture Techniques; Cell Line; Cells; Center for Translational Science Activities; Clinical; Clinical Data; Collaborations; Colon; Comprehensive Cancer Center; Computerized Medical Record; Consent; Consultations; Cryopreserved Tissue; Custom; DNA; Data; Databases; Dedications; Evaluation; Feedback; Female; Formalin; Freezing; Funding; Genomics; Goals; Grant; Hispanic; Histology; Human; Image Analysis; Immunohistochemistry; Immunology; Industry; Infrastructure; Intranet; Journals; Kidney; Leadership; Liquid substance; Lung; Malignant Neoplasms; Malignant neoplasm of lung; Medical center; Medicine; Methodology; Molecular; Mus; NCI Center for Cancer Research; National Cancer Institute; Nature; Normal tissue morphology; Not Hispanic or Latino; Online Systems; Pancreas; Participant; Pathologic; Pathologist; Pathology; Peer Review; Plasma; Pleural; Primary carcinoma of the liver cells; Principal Investigator; Prostate; Publications; Publishing; Quality Control; RNA; Renal carcinoma; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Science; Serum; Services; Signal Transduction; Specialized Program of Research Excellence; Specimen; Stomach; Surveys; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Tumor Cell Line; Tumor Tissue; Urine; Work; biobank; cancer cell; human model; innovation; insight; melanoma; member; preservation; programs; prospective; response; searchable database; success; tissue fixing; tumor; tumor registry; web interface; web portal; whole slide imaging

The goals of Simmons Comprehensive Cancer Center (SCCC) Tissue Management Shared Resource (TMSR) are to facilitate the storage and distribution of comprehensively annotated, high-quality biospecimens and their derivatives and to provide professional and technical pathology services to investigators and collaborators within and outside of SCCC. Under the leadership of Adam Yopp, MD, the TMSR delivers basic histomorphological evaluation of human tumors and human tumor grafts in mice, as well as basic and advanced immunohistochemistry (IHC) services, creates custom tissue microarrays (TMA), and provides whole slide imaging and image analysis. In addition, the TMSR offers unique cancer-tissue derivatives such as primary cancer cell cultures and cell lines, cryopreserved tissues, DNA, and RNA. The TMSR currently has greater than 37,000 fresh frozen tissues and 42,000 formalin-fixed tissues, as well as clinically annotated TMAs with paired tumor and normal tissue from the following malignancies: breast, hepatocellular carcinoma, colon, lung, melanoma, gastric, and pancreas. In addition, the TMSR currently has greater than 42,000 serum and plasma blood samples and 8,000 buffy coat samples. Samples are listed in an annotated and searchable database that is available to SCCC members through the intranet. The TMSR provides routine quality controls for all prospectively consented collected specimens. The TMSR has had significant utilization, with greater than 3,500 samples having been distributed to investigators internally and externally in 2019. The TMSR promotes flourishing collaborations among SCCC investigators, investigators from other National Cancer Institute (NCI)- designated Comprehensive Cancer Centers, and other investigators in academia and industry. The services of the TMSR were utilized by 78 investigators across five SCCC Research Programs in 2019, providing key data and insights to support the success of NCI-funded research grants, including the lung and kidney cancer SPORE grants and 115 peer-reviewed publications, with work published in high-impact journals such as JCI, Cancer Discovery, Science Signaling, Science Immunology, Nature, and Nature Medicine. Over the current cycle, the TMSR had over a 100% increase in its usage due to rapid response to investigator needs and SCCC priorities.

Simmons综合癌症中心（SCCC）组织管理共享资源（TMSR）的目标 是为了促进全面注释，高质量的生物测量及其的存储和分布 衍生品并向调查人员和合作者提供专业和技术病理服务 在SCCC之外。在医学博士Adam Yopp的领导下，TMSR提供了基本的组织形态学 评估小鼠的人类肿瘤和人类肿瘤移植物，以及基本和晚期 免疫组织化学（IHC）服务，创建自定义组织微阵列（TMA），并提供全部幻灯片 成像和图像分析。此外，TMSR提供独特的癌症组织衍生物，例如主要 癌细胞培养和细胞系，冷冻保存的组织，DNA和RNA。 TMSR目前具有大于 37,000个新鲜的冷冻组织和42,000个福尔马林固定组织，以及配对的临床注释的TMA 肿瘤和正常组织来自以下恶性肿瘤：乳腺癌，肝细胞癌，结肠，肺，肺部， 黑色素瘤，胃和胰腺。此外，TMSR目前具有超过42,000的血清和等离子体 血液样本和8,000个Buffy外套样品。样本在一个注释且可搜索的数据库中列出 可通过Intranet向SCCC成员使用。 TMSR为所有人提供常规质量控制 前瞻性同意收集的标本。 TMSR具有大量利用，超过3500 样本已于2019年内部和外部分发给研究人员。TMSR促进 SCCC研究人员，其他国家癌症研究所（NCI）的研究人员之间的繁荣合作 - 指定的综合癌症中心以及学术界和工业的其他研究人员。服务 TMSR在2019年的五个SCCC研究计划中被78位调查人员使用，提供了关键数据 和见解以支持NCI资助的研究补助金，包括肺癌和肾癌孢子 赠款和115个同行评审的出版物，在JCI，癌症等高影响期刊上发表了作品 发现，科学信号，科学免疫学，自然和自然医学。在当前周期中， 由于对研究者需求和SCCC优先级的响应迅速，TMSR的使用率超过100％。