Optimizing mHealth for adherence monitoring and intervention

优化移动医疗以进行依从性监测和干预

• 批准号: 10251996
• 负责人: Jessica Elizabeth Haberer
• 金额: $ 18.15万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10251996
• 关键词: AIDS prevention; Adherence; Africa; Anti-Retroviral Agents; Award; Boston; Caring; Consolidated Framework for Implementation Research; Counseling; Data; Development; Dose; Faculty; Feedback; Foundations; Funding; General Hospitals; Goals; Grant; Growth; HIV; HIV antiretroviral; Health Benefit; Health Technology; Individual; Infrastructure; Ingestion; Institution; International; Internist; Intervention; Lead; Manuscripts; Massachusetts; Medicine; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Monitor; National Institute of Mental Health; Paper; Pattern; Peer Review; Pharmaceutical Preparations; Postdoctoral Fellow; Principal Investigator; Process; Productivity; Proxy; Publications; Research; Research Personnel; Rewards; Risk; Role; Rural; Structure; Talents; Text Messaging; Time; Training; Tuberculosis; Uganda; United States National Institutes of Health; Viral; Work; Writing; antiretroviral therapy; base; burden of illness; career; clinical care; comorbidity; design; doctoral student; experience; global health; implementation science; implementation strategy; improved; interest; mHealth; medical schools; mid-career faculty; patient oriented research; pill; pre-doctoral; programs; skills; therapy adherence; tool; uptake; viral rebound; viral transmission

Project summary Overview. This application for a K24 mid-career investigator award proposes to support mentoring for junior investigators interested in mHealth to improve adherence monitoring and intervention for HIV and related comorbid conditions. Candidate: Dr. Haberer is a practicing internist, the Director of Research at the Massachusetts General Hospital (MGH) Center for Global Health, and an Associate Professor of Medicine at Harvard Medical School (HMS). She has nearly 10 years of experience studying adherence to antiretroviral therapy for both the treatment and prevention of HIV in developing settings, with a particular focus on mHealth. Dr. Haberer is considered a leader in her field and most specifically in electronic adherence monitors and SMS-based monitoring and intervention. Dr. Haberer is also a dedicated mentor and has supported 21 pre-doctoral students, residents, post-doctoral fellows and junior faculty, both in Boston and abroad. Her mentees have written 18 first author papers (5 additional papers are in process) and received six NIH-funded grants with her guidance. As a testament to her mentoring, she won the prestigious HMS Young Mentor Award in 2014. Mentoring Plan: Dr. Haberer’s mentoring goals are to 1) increase mentoring activities in mHealth-based adherence monitoring and intervention; and 2) establish a structured mentoring program at the MGH Center for Global Health. She can access mentees through MGH, HMS, and other Harvard-affiliated institutions, as well as her research partner institutions in East Africa. Dr. Haberer is currently the principal investigator on two R01 grants through NIMH, as well as a large scale grant through the Bill and Melinda Gates Foundation. She therefore has the capacity for numerous mentees to participate in her on-going studies through analysis of existing data and supplemental projects. Dr. Haberer will also be expanding her research into implementation science, in which she will engage additional mentees. She has been receiving an increasing number of requests for mentorship that would require the support of this award. Research Plan: Dr. Haberer proposes to expand her research program into implementation science for mHealth-based adherence monitoring and intervention. This goal involves both acquiring formal training in implementation science, as well as conducting implementation science research on the use of electronic ART adherence monitoring plus support for routine clinical care in Uganda. She aims to 1) conduct multi-level formative work to design a preliminary implementation strategy; and 2) use an iterative approach to optimize the implementation strategy based on the Consolidated Framework for Research Implementation. This proposed research will help determine ways to move effective mHealth tools from the research context into routine clinical care, as well as advance Dr. Haberer’s career and serve as a platform for mentee involvement.

项目摘要 概述。这项申请K24中级研究员裁决提案，以支持初级的心理 对MHealth感兴趣的调查人员，以改善艾滋病毒及相关的依从性监测和干预措施 合并条件。 候选人：Haberer博士是马萨诸塞州将军的实践内科医生，研究主任 医院（MGH）全球健康中心，哈佛医学院医学副教授 （HMS）。她有将近10年的研究经验，他们研究了抗逆转录病毒疗法 在发展环境中的治疗和预防艾滋病毒，特别关注MHealth。 Haberer博士是 被认为是她领域的领导者，最具体地说是电子依从性监测器和基于SMS的领导者 监视和干预。 Haberer博士也是一个精神上的精神，并支持了21个博士后 在波士顿和国外，学生，居民，博士后研究员和初级教师。她的受训者有 书面的18篇作者论文（正在处理另外5篇论文），并与她获得了6份NIH资助的赠款 指导。为了证明她的心理，她在2014年获得了著名的HMS年轻导师奖。 指导计划：Haberer博士的心理目标是1）增加基于MHealth的心理活动 依从性监测和干预； 2）在MGH中心建立一个结构化的心理计划 全球健康。她也可以通过MGH，HMS和其他哈佛附属机构进入月经 作为她在东非的研究合作伙伴机构。 Haberer博士目前是两个R01的首席调查员 通过NIMH赠款，以及通过Bill和Melinda Gates Foundation的大规模赠款。她 因此，通过分析 现有数据和补充项目。 Haberer博士还将将她的研究扩展到实施 科学，她将与更多的门德一起参与其中。她一直在收到越来越多的 需要支持该奖项的征服要求。 研究计划：Haberer博士的提议将其研究计划扩展到实施科学 基于MHealth的依从性监测和干预。这个目标既涉及接受正式培训 实施科学以及对电子艺术使用的实施科学研究 依从性监测加上对乌干达常规临床护理的支持。她的目标是1）进行多层次 设计初步实施策略的形成性工作； 2）使用迭代方法优化 基于研究实施的合并框架的实施策略。这 拟议的研究将有助于确定将有效MHealth工具从研究环境转移到的方法 例行的临床护理以及提高Haberer博士的职业生涯，并成为Menee参与的平台。

项目成果

Factors Affecting the Implementation of Electronic Antiretroviral Therapy Adherence Monitoring and Associated Interventions for Routine HIV Care in Uganda: Qualitative Study.

• DOI: 10.2196/18038
• 发表时间: 2020-09-10
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Haberer JE;Garrison L;Tumuhairwe JB;Baijuka R;Tindimwebwa E;Tinkamanyire J;Burns BF;Asiimwe S
• 通讯作者: Asiimwe S

The impact of prevention-effective PrEP use on HIV incidence: a mathematical modelling study.

• DOI: 10.1002/jia2.26034
• 发表时间: 2022-11
• 期刊: JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
• 影响因子: 6
• 作者: Roberts, D. Allen;Bridenbecker, Daniel;Haberer, Jessica E.;Barnabas, Ruanne V.;Akullian, Adam
• 通讯作者: Akullian, Adam

A mobile health app may improve maternal and child health knowledge and practices among rural women with limited education in Uganda: a pilot randomized controlled trial.

• DOI: 10.1093/jamiaopen/ooac081
• 发表时间: 2022-12
• 期刊: JAMIA OPEN
• 影响因子: 2.1
• 作者: Musiimenta, Angella;Tumuhimbise, Wilson;Atukunda, Esther C.;Mugaba, Aaron T.;Asasira, Justus;Katusiime, Jane;Zender, Raphael;Pinkwart, Niels;Mugyenyi, Godfrey Rwambuka;Haberer, Jessica E.
• 通讯作者: Haberer, Jessica E.

Brief Report: The Impact of Disease Stage on Early Gaps in ART in the "Treatment for All" Era-A Multisite Cohort Study.

• DOI: 10.1097/qai.0000000000002605
• 发表时间: 2021-04-15
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Katz IT;Musinguzi N;Bell K;Cross A;Bwana MB;Amanyire G;Asiimwe S;Orrell C;Bangsberg DR;Haberer JE;META (Measuring Early Treatment Adherence) Team Investigators
• 通讯作者: META (Measuring Early Treatment Adherence) Team Investigators

Perceived oral health interventions by medical providers in Gugulethu, South Africa.

南非古古莱图医疗服务提供者对口腔健康干预措施的看法。

• DOI: 10.1371/journal.pone.0233437
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Lambert,RFrederick;Yu,Amy;Orrell,Catherine;Haberer,JessicaE
• 通讯作者: Haberer,JessicaE