Assessing the Relative and Absolute Risk for site-Specific Cancer Mortality attributed to Household Air Pollution

评估家庭空气污染导致的特定地点癌症死亡率的相对和绝对风险

基本信息

批准号：
10252046
负责人：
H Dean Hosgood
金额：
$ 37.21万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-02 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10252046
关键词：
Accounting Address Asia Biomass Burn injury Calendar Carcinogens Case-Control Studies Cessation of life Coal Cohort Studies Data Disease Environmental Risk Factor Epidemiology Esophagus Etiology Exposure to Family Female Fibrinogen Genes Genetic Genetic Variation Geographic Locations Geography Health Heterogeneity Household Household Air Pollution Human Individual International Agency for Research on Cancer Larynx Lead Lung Malignant Neoplasms Malignant neoplasm of esophagus Malignant neoplasm of larynx Malignant neoplasm of lung Malignant neoplasm of nasopharynx Malignant neoplasm of pharynx Measures Methods Modeling Nitrogen Dioxide North America Oropharyngeal Participant Policies Population Population Attributable Risks Positioning Attribute Process Prospective Studies Prospective cohort Public Health Questionnaires Recording of previous events Regulation Relative Risks Research Resources Risk Risk Estimate Risk Factors Sample Size Site Smoker Smoking Status Statistical Methods Time Tobacco smoke Tobacco smoking behavior Wood material ambient air pollution base burden of illness cancer risk cancer site carcinogenicity coarse particles cohort design disorder risk environmental tobacco smoke experience fine particles genetic variant genome wide association study male malignant mouth neoplasm mortality multiple data sources never smoker novel prospective pulmonary function sex smoking exposure solid fuel

项目摘要

Household air pollution (HAP) attributed to wood use is a potential environmental risk factor for lung cancer, to which ~2.5 billion people worldwide (including >15 million in the US) are exposed. Known lung cancer risk factors (i.e., environmental tobacco smoke (ETS), outdoor air pollution (OAP), family history) do not fully account for the disease burden. To reach robust conclusions about biomass's pulmonary carcinogenicity and the lung cancer deaths attributed to HAP while accounting for confounding exposures, prospective studies of individuals experiencing a variety of exposure levels of HAP, ETS, and other suspected lung carcinogens are needed. We will leverage our global consortium of prospective studies (HAPCO: Household Air Pollution Cohorts), which is a pooled resource of >550,000 subjects, to for the first time accurately quantify the relative risk of lung cancer mortality associated with wood use. Further, we will estimate time-dependent population-attributable fraction (PAF) function for lung cancer mortality, which will measure the potential reduction in lung cancer mortality if HAP is eliminated or reduced while adjusting for known and suspected lung carcinogens (i.e., ETS, OAP). Our robust harmonization of HAP data will also provide the unique opportunity to determine the relative and absolute risks associated with HAP exposures for cancers other than lung cancer, which was recently highlighted by an expert panel convened by multiple US Federal Agencies.

造成木材使用的家庭空气污染（HAP）是肺癌的潜在环境危险因素，全世界约有25亿人口（包括在美国> 1500万人）。已知的肺癌危险因素（即环境烟草烟雾（ETS），户外空气污染（OAP），家族史）不完全考虑疾病负担。要得出关于生物质肺癌和肺癌死亡的强大结论归因于HAP在考虑混淆暴露时，对经历的个人的前瞻性研究需要多种暴露水平的HAP，ETS和其他可疑的肺癌。我们将利用我们的全球前瞻性研究联盟（HAPCO：家庭空气污染队列），这是一个合并的资源 > 550,000名受试者，首次准确地量化了与肺癌死亡率相关的相对风险使用木材。此外，我们将估计肺的时间依赖性种群 - 归类分数（PAF）功能癌症死亡率，如果消除HAP或降低，将衡量肺癌死亡率的潜在降低同时调整已知和怀疑的肺癌（即ETS，OAP）。我们对HAP数据的强大协调还将提供独特的机会来确定与HAP暴露相关的相对风险和绝对风险对于肺癌以外的其他癌症，最近由美国召集的专家小组强调了该癌症联邦机构。