Relative Sarcopenia and Cardiometabolic Risk in Young Adults with Obesity

肥胖年轻人的相对肌肉减少症和心脏代谢风险

• 批准号: 10240291
• 负责人: Melanie Schorr Haines
• 金额: $ 19.83万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-12 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240291
• 关键词: Adult; Age Factors; Appointment; Atherosclerosis Risk in Communities; Award; Body mass index; Cardiometabolic Disease; Center for Translational Science Activities; Central obesity; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Coronary Artery Risk Development in Young Adults Study; Data; Deposition; Elderly; Endocrine Physiology; Environment; Epidemiology; Faculty; Fatty acid glycerol esters; Fostering; Funding; Future; General Hospitals; Genetic Risk; Glucose; Goals; Grant; Hormones; Hospital Departments; Imaging Techniques; Impairment; Insulin Resistance; Lead; Link; Lipids; Massachusetts; Mediating; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Muscle; National Health and Nutrition Examination Survey; Neuroendocrinology; Neurosecretory Systems; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Peripheral; Phenotype; Prevalence; Prevention; Prospective Studies; Public Health; Publications; Radiology Specialty; Research; Research Personnel; Research Support; Resources; Risk; Risk Factors; Single Nucleotide Polymorphism; Skeletal Muscle; Somatotropin; Study Subject; Targeted Research; Testosterone; Thinness; Time; Training; United States National Institutes of Health; Visit; Woman; adiponectin; adult obesity; cardiometabolic risk; career; design; diabetes risk; follow-up; genetic epidemiology; genetic variant; hormone deficiency; instructor; lifestyle factors; medical schools; men; mitochondrial dysfunction; multidisciplinary; muscle form; musculoskeletal imaging; patient oriented; programs; recruit; reduced muscle mass; risk prediction model; sarcopenia; sex; skills; success; young adult

PROJECT SUMMARY/ABSTRACT Obesity is a well-known cardiometabolic disease risk factor and growing public health problem. However, little is known about the impact of muscle mass and quality on cardiometabolic risk, including type 2 diabetes (DM), especially in young adults with overweight/obesity. The proposed research has the potential to identify targets for the prevention and treatment of this public health problem. The central hypothesis is that relative sarcopenia (i.e. low muscle mass relative to BMI) and impaired muscle quality (i.e. intramyocellular lipid (IMCL) and mitochondrial dysfunction) contribute to higher DM risk over time in young adults with overweight/obesity. We also hypothesize that common genetic variants associated with insulin resistance, as well as obesity-related relative hormone deficiencies, contribute to relative sarcopenia and impaired muscle quality and lead to higher DM risk. The candidate is an Instructor of Medicine at Harvard Medical School and Assistant in Medicine at Massachusetts General Hospital (MGH) who is highly qualified for and deeply committed to developing a career as an independent investigator. Her short-term goal is to develop the skills and obtain the preliminary data necessary to make the transition to her first R-level independent NIH grant-supported research. Her long- term goal is to become an independent patient-oriented researcher leveraging genetic epidemiology, endocrine physiology and sophisticated imaging techniques to elucidate mechanisms that may contribute to increased cardiometabolic risk in young adults with overweight/obesity, and to identify potential targets for both prevention and treatment. She has an outstanding track record of success, including awards, pilot grants and publications, and is supported by an expert and highly invested mentorship team composed of successful, NIH-supported clinical investigators in Neuroendocrinology, Radiology, Epidemiology and Genetic Epidemiology. She and her mentors have designed a targeted training plan consisting of co-mentorship and a didactic program. The institutional environment is outstanding at MGH and Harvard Medical School, with multiple resources available from the MGH Department of Medicine, the MGH Division of Clinical Research, and the Harvard Clinical and Translational Science Center, all of which offer a myriad of didactic opportunities, facilities and support to the candidate. The Neuroendocrine Unit and Department of Medicine have made a strong commitment to the candidate, including 90% protected time, space, study coordinator support and a faculty appointment, with the goal of fostering the candidate's career as an independent investigator.

项目摘要/摘要 肥胖是众所周知的心脏代谢疾病危险因素和公共卫生问题的日益增长。但是，很少 知道肌肉质量和质量对心脏代谢风险的影响，包括2型糖尿病（DM）， 特别是在超重/肥胖的年轻人中。拟议的研究有可能识别目标 用于预防和治疗这一公共卫生问题。 中心假设是相对肌肉减少症（即低肌肉质量相对于BMI）和肌肉受损 质量（即细胞内脂质（IMCL）和线粒体功能障碍）随着时间的推移有助于更高的DM风险 在超重/肥胖的年轻人中。我们还假设与 胰岛素抵抗以及与肥胖相关的相对激素缺乏症，有助于相对肌肉减少症 肌肉质量受损，并导致更高的DM风险。 候选人是哈佛医学院的医学教练，也是医学助理 马萨诸塞州综合医院（MGH）高度有资格并致力于开发 作为独立调查员的职业。她的短期目标是发展技能并获得初步 将其过渡到她的第一个R级独立NIH赠款支持的研究所必需的数据。她的长期 术语目标是成为一个独立的面向患者的研究人员，利用遗传流行病学，内分泌 生理学和复杂的成像技术，以阐明可能有助于增加的机制 超重/肥胖的年轻人的心脏代谢风险，并确定两者的潜在目标 预防和治疗。她拥有成功的杰出记录，包括奖项，飞行员赠款和 出版物，并得到由成功的专家和投资高度投资的指导团队的支持， NIH支持的神经内分泌，放射学，流行病学和遗传学的临床研究者 流行病学。她和她的导师设计了一个有针对性的培训计划，包括会议和 教学计划。 机构环境在MGH和Harvard医学院很出色，拥有多种资源 可从MGH医学系，MGH临床研究部和哈佛大学获得 临床和转化科学中心，所有这些都提供了无数的教学机会，设施和 支持候选人。神经内分泌部门和医学系已有很强 对候选人的承诺，包括90％的受保护时间，空间，学习协调员的支持和教师 任命，目的是培养候选人作为独立调查员的职业。