Regional Centre for Vector Borne Diseases in West Africa (RCVBD)

西非媒介传播疾病区域中心 (RCVBD)

• 批准号: 10239374
• 负责人: YAW ASARE AFRANE
• 金额: $ 24.84万
• 依托单位: UNIVERSITY OF GHANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-16 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10239374
• 关键词: Africa; African; Anti-malarial drug resistance; Area; Artemisinins; Bioinformatics; Burkina Faso; California; Communicable Diseases; Communities; Developed Countries; Disease model; Educational workshop; Entomology; Epidemiology; Faculty; Fostering; Gambia; Genetic; Genomics; Ghana; Goals; Health; Insecticide Resistance; Institution; Intervention; Knowledge; Malaria; Medical Entomology; Medical Research; Mentorship; Modeling; Molecular; New Mexico; Pharmaceutical Preparations; Population; Population Genetics; Productivity; Publications; Research; Research Training; Science; Scientist; Techniques; Training; Training Programs; Universities; Vector-transmitted infectious disease; career; doctoral student; faculty research; malaria transmission; next generation; skills; tool

PROJECT SUMMARY Although West Africa is currently burdened with an unprecedented high levels of malaria, the research capacity in Africa is too low to meet the malaria control and elimination goal. Furthermore, many new techniques and tools developed in the developed countries have not been well utilized by Africa scientists. For example, new tools in molecular population genetics, genomics and bioinformatics and disease modeling have not been integrated into malaria research and control in Africa. Low research capacity in West Africa is far more dire in comparison to other African regions. Therefore, there is an immediate need to strengthen the research capacity in infectious diseases in West Africa. We propose this Regional Centre for Vector Borne Diseases in West Africa (RCVBD) to enhance research capacity in malaria epidemiology and medical entomology through training PhD students and junior faculty and research scientists. The consortium partners are from three West African institutions (University of Ghana, The Medical Research Council Unit Gambia, and Institut de Recherche en Sciences de la Santé of Burkina Faso). Collaborators from three US institutions (University of California at Irvine, University of New Mexico and the Northwestern University) will assist the training program. The overall goal of this training program is to enhance research capacity in West Africa by training the next generation of African scientists in the area of vector-borne disease research and control with a special focus on malaria. The thematic areas of training include epidemiology, medical entomology and application of new genetic, genomic and ecological research tools. We propose three tracks of training. Track 1 will be long-term training of 8 PhD students in West Africa. Track 2 will provide short- term research training to 15 junior university faculty and junior scientists from the Ministry of Health in West Africa to foster specific skills required for malaria research and control. Track 3 will be training workshops and short courses to disseminate techniques and knowledge to wide communities involved in vector borne disease research and control in West Africa. This training program will focus on four scientific areas in urgent need, including 1) new tools for malaria epidemiological and entomological surveillance, 2) antimalarial drug resistance to artemisinin and partner drugs, 3) population genomics of insecticide resistance, and 4) modeling malaria transmission dynamics and malaria intervention strategies. This research training program will help advance the careers of West African scientists by strengthening their academics and research productivity through vigorous mentorship and outstanding publications, equipping them with new knowledge and skills, and enhancing their collaborative opportunities with scientists within and out of Africa.

项目摘要 尽管西非目前被史无前例的高疟疾烧毁，但该研究 非洲的能力太低，无法实现疟疾控制和消除目标。此外，许多新事物 发达国家开发的技术和工具尚未得到非洲的良好利用 科学家。例如，分子种群遗传学，基因组学和生物信息学的新工具以及 疾病模型尚未纳入非洲的疟疾研究和控制。低研究 与其他非洲地区相比，西非的能力更加可怕。因此，有一个 立即需要加强西非传染病的研究能力。我们建议 这个在西非的媒介传播疾病区域中心（RCVBD）增强了研究能力 通过培训博士学位学生和初级教师以及 研究科学家。财团合作伙伴来自三个西非机构（大学 加纳，医学研究委员会部门冈比亚和科学研究所 布基纳法索的桑特）。来自美国三个机构的合作者（加利福尼亚大学尔湾分校， 新墨西哥大学和西北大学）将协助培训计划。总体 该培训计划的目标是通过训练来提高西非的研究能力 在媒介传播疾病研究和控制领域的非洲科学家的产生 特别关注疟疾。培训的主题领域包括流行病学，医学昆虫学 以及新遗传，基因组和生态研究工具的应用。我们提出了三个曲目 轨道1将是对西非8个博士生的长期培训。轨道2将提供短暂的 对15名初级大学教职员工和卫生部初级科学家的学期培训 西非培养疟疾研究和控制所需的特定技能。轨道3将训练 讲习班和简短的课程，以将技术和知识传播给所涉及的广泛社区 在西非的媒介传播疾病研究和控制中。该培训计划将重点关注四个 迫切需要的科学领域，包括1）疟疾流行病学和昆虫学的新工具 监视，2）对青蒿素和伴侣药物的抗疟疾药物耐药性，3）种群基因组学 杀虫剂的耐药性，4）建模疟疾传播动力学和疟疾干预 策略。该研究培训计划将帮助推进西非科学家的职业 通过积极的心态和杰出的心态增强学术和研究生产力 出版物，为他们提供新的知识和技能，并增强其协作 与非洲内外科学家的机会。