Bioinformatics and Biostatistics Core

生物信息学和生物统计学核心

基本信息

批准号：
10267846
负责人：
Jeffrey Peter Townsend
金额：
$ 25.44万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10267846
关键词：
Address Adverse event Basic Science Bioinformatics Biometry Biostatistics Core Clinical Clinical Data Clinical Research Clinical Sciences Clinical Trials Collaborations Collection Communication Computers Computing Methodologies Consult Consultations Data Data Analyses Databases Development Employment Ensure Experimental Designs Faculty Fox Chase Cancer Center Funding Futility Goals Head and Neck Cancer Head and neck structure Individual Informatics Investigation Laboratories Leadership Malignant Neoplasms Manuscripts Medicine Methodology Methods Monitor Monitoring Clinical Trials Patient Care Physicians Play Policies Population Population Sciences Population Study Prevention strategy Privacy Procedures Program Development Publications Randomized Reproduction spores Research Research Personnel Research Proposals Resources Role Safety Sample Size Schedule Science Sequence Analysis Services Suggestion System Time Translational Research Work Writing Yale Cancer Center base career development data management data mining design experimental study frontier genomic data innovation meetings member multidimensional data next generation next generation sequencing pre-clinical programs research and development therapy resistant tool translational study treatment strategy web-accessible

项目摘要

Project Summary The goal of the Biostatistics and Bioinformatics Core (Core C) is to address the statistical design and analysis needs of the Yale SPORE in Head and Neck Cancer (YHN-SPORE) Projects, the Cores, the Developmental Research Program (DRP), and the Career Development Program (CDP). To accomplish this goal we have assembled a highly interactive team of cancer biostatisticians and bioinformaticians who will work collaboratively with basic, clinical, translational, and population science researchers to advance the frontiers of cancer medicine. The specific aims of the Biostatistics and Bioinformatics Core are: Aim 1: Provide collaboration and consulting in the design, execution, monitoring and analysis of basic, translational, population, and clinical studies for YHN-SPORE. Aim 2: Oversee and coordinate the collection, management, and analysis of data. Ensure that data collected on all YHN-SPORE studies are of high quality, are evaluated with bioinformatic and statistical rigor, are accessible within SPORE-affiliated collaborative groups, ultimately enabling the widest accessibility that is appropriate given publication and privacy concerns. For Aim 1, the Core will work closely with the investigators to analyze clinical trial and pre-clinical data, next generation sequencing data, and bioinformatics data mining. Services provided by the Core will range from planning and design activities to consulting on specific analytic questions. The Core will address the analytic and informatics questions arising from the YHN-SPORE projects. The Core will rigorously design and monitor clinical trials for safety, efficacy and futility. The Core will schedule regular meetings with the YHN-SPORE investigators, and maintain an open-door policy for any biostatistical and bioinformatics questions. The Core will conduct interim and final analyses, develop new statistical and bioinformatics methodology as needed, provide timely suggestions to YHN-SPORE investigators, and thus play an important role in the entire study. Biostatistics and Bioinformatics is also a key partner in the YHN-SPORE with representation on their Senior Leadership Team and participation in all core meetings. For Aim 2, The Core will work with the Yale Cancer Center (YCC), Yale Center for Analytical Sciences (YCAS), Fox Chase Cancer Center (FCCC) and its quantitative cores to facilitate communication among YHN-SPORE researchers, creating and implementing web-accessible databases for collecting, storing and accessing the various types of data (e.g. laboratory, clinical, population, and genomic data) that will be generated for the YHN-SPORE projects. The Core is highly integrated with the projects, and will have regular meetings with project investigators, as well as YCAS data managers, to evaluate the data generated from the studies and ensure accurate and up-to-date data management.

项目摘要生物统计学和生物信息学核心（核心C）的目标是解决统计设计和分析耶鲁孢子在头颈癌（YHN-Spore）项目，核心，发育中的需求研究计划（DRP）和职业发展计划（CDP）。为了实现这一目标，我们组建了一个高度互动的癌症生物统计学家和生物信息学家，他们将工作与基本，临床，转化和人群科学研究人员合作，以推动癌症医学。生物统计学和生物信息学核心的具体目的是：目标1：提供基本设计，执行，监视和分析的协作和咨询， YHN-Spore的翻译，人口和临床研究。目标2：监督和协调数据的收集，管理和分析。确保收集数据在所有YHN的研究中，都具有高质量，用生物信息学和统计严格评估可以在孢子附属的协作小组中访问，最终使最广泛的可访问性适当的出版物和隐私问题。对于AIM 1，核心将与研究人员紧密合作，以分析临床试验和临床前数据，接下来生成测序数据和生物信息学数据挖掘。核心提供的服务范围从计划和设计活动以咨询特定的分析问题。核心将解决分析以及YHN-Spore项目引起的信息问题。核心将严格设计和监视有关安全性，效率和徒劳的临床试验。核心将安排与YHN-Spore的定期会议调查人员，并为任何生物统计和生物信息学问题保持开放式政策。核心将进行临时和最终分析，根据需要开发新的统计和生物信息学方法，向YHN的研究人员提供及时的建议，从而在整个研究中发挥重要作用。生物统计学和生物信息学也是YHN-Spore的关键合作伙伴，代表他们领导团队和参加所有核心会议。对于AIM 2，核心将与耶鲁癌症一起使用中心（YCC），耶鲁大学分析科学中心（YCAS），Fox Chase Cancer Center（FCCC）及其定量核心，以促进YHN的研究人员之间的交流，创建和实施用于收集，存储和访问各种数据的Web访问数据库（例如，实验室，临床，人口和基因组数据）将为YHN的项目生成。核心很高与项目集成在一起，并将与项目调查人员以及YCAS数据定期开会管理人员，评估从研究产生的数据并确保准确，最新的数据管理。になったんです。英语：您可以做的第一件事就是找到最好的方法。になったんです。英语：您可以做的第一件事就是找到最好的方法。