Virus Taxonomy: A Community Knowledgebase Supporting Virus Research

病毒分类学：支持病毒研究的社区知识库

• 批准号: 10269527
• 负责人: Elliot J. Lefkowitz
• 金额: $ 59.4万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-03 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10269527
• 关键词: 2019-nCoV; Acute; Agriculture; Animals; Biological; Biology; COVID-19; Classification; Collection; Communities; Computer Systems; Computers; Custom; Data; Data Set; Databases; Development; Disease; Disease Outbreaks; Ecology; Ecosystem; Education; Education and Outreach; Educational workshop; Effectiveness; Ensure; Environment; Funding; General Population; Generations; Goals; Government; Government Agencies; Health; Health Sciences; Human; Individual; Information Technology; Infrastructure; International; Internet; Knowledge; Link; Manuals; Medical; Mission; Modernization; National Security; Nomenclature; Online Systems; Organism; Outcome; Pharmacologic Substance; Planets; Play; Policies; Policy Maker; Prevention; Privatization; Property; Research; Resources; Risk; Role; Sampling; Science; Scientist; Security; Standardization; Students; System; Taxonomy; Testing; Training; Training Activity; Training Programs; Virus; Virus Diseases; Visual; Work; analytical tool; base; cloud based; data access; flexibility; improved; innovation; interest; interoperability; knowledge base; knowledge repository; meetings; novel; open source; outreach program; programs; repository; response; science and society; social media; success; support tools; tool; virology; virome; virus classification; virus resource

PROJECT SUMMARY/ABSTRACT Viruses are able to infect every kind of organism on the planet. They play an integral part in maintaining normal ecosystems but sometimes cause perturbations that have adverse impacts on human health, agriculture, and the wider environment. Understanding the role that viruses play in ecosystems and developing approaches to mitigate their undesirable effects represents a major goal of virologists. Organisms can only be understood in the context of their relationships. This begins with the delineation of common and distinguishing properties and is formalized by the science of taxonomy which creates an ordered, hierarchical system of classification and nomenclature. Taxonomy is critical for building a holistic understanding of the biology of the organisms that inhabit this planet. The International Committee on Taxonomy of Viruses (ICTV) provides a coherent framework for understanding viruses by classifying them on the basis of their kinships as described by the virus taxonomy. The ICTV taxonomic database and programs form the bedrock used by virologists worldwide to understand the global virome, standardize the nomenclature of the huge influx of newly discovered viruses, and promote both research and education in a rapidly changing environment. This proposal is aimed at expanding the effectiveness of the ICTV and strengthening its connections to a broad range of stakeholders. These include people involved in scientific, veterinary, medical, educational, and regulatory endeavors, and anyone else interested in viruses. Our aims focus on providing an integrated set of outcomes that modernized resources to ensure a stable, responsive, scalable infrastructure; increased availability and breadth of taxonomic and virological information; better tools to manage taxonomic classification and handling of data supporting high-throughput virus classification and curation; enhanced accessibility by individuals, groups, and information repositories; and outreach and training activities to ensure that the products of our efforts are used to benefit stakeholders and to promote better understanding of viruses and their classification. This work will advance the capacity of bench scientists, computer scientists, educators, trade regulators, pharmaceutical firms, government agencies, policy makers, and the general public to conduct leading edge research, mitigate the threat posed by viruses, and better understand the risks posed by viruses to human, animal, and agricultural health, and the planet’s ecology. This work will also contribute to national and international security by helping governments to respond to unforeseen outbreaks of virus diseases such as COVID-19.

项目概要/摘要 病毒能够感染地球上的各种生物体，它们在维持正常生活中发挥着不可或缺的作用。 生态系统，但有时会造成扰动，对人类健康、农业和农业产生不利影响 了解病毒在生态系统中发挥的作用并制定应对方法 减轻其不良影响是病毒学家的主要目标。 有机体只能在其关系的背景下才能被理解。这从描述有机体开始。 共同和区别的属性，并通过分类科学形式化，它创建了有序的、 分类和命名的层次系统对于建立整体理解至关重要。 国际病毒分类委员会的生物学研究。 （ICTV）通过根据亲缘关系对病毒进行分类，提供了一个理解病毒的连贯框架 正如病毒分类所描述的那样，ICTV 分类数据库和程序构成了病毒分类所使用的基础。 世界各地的病毒学家了解全球病毒组，标准化大量涌入的新病毒的命名 发现病毒，并在快速变化的环境中促进研究和教育。 旨在扩大ICTV的有效性并加强其与广泛领域的联系 这些利益相关者包括参与科学、兽医、医疗、教育和监管的人员。 努力以及任何其他对病毒感兴趣的人。 我们的目标侧重于提供一套综合的成果，使资源现代化，以确保稳定、 反应灵敏、可扩展的基础设施；增加分类学和病毒学信息的可用性和广度； 更好的工具来管理分类学分类和支持高通量病毒的数据处理 分类和管理；增强个人、团体和信息存储库的可访问性； 外展和培训活动，以确保我们的努力成果用于造福利益相关者并 促进更好地了解病毒及其分类。 这项工作将提高基础科学家、计算机科学家、教育工作者、贸易监管者的能力， 制药公司、政府机构、政策制定者和公众开展前沿研究 研究，减轻病毒造成的威胁，更好地了解病毒对人类造成的风险， 这项工作也将为国家和农业健康做出贡献。 通过帮助各国政府应对不可预见的病毒性疾病爆发来维护国际安全，例如 新冠肺炎。