Chemical Synthesis Core

化学合成核心

基本信息

批准号：
10262764
负责人：
Joel Schneider
金额：
$ 42.99万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

项目摘要

Typically, either a PI in need of assistance or the Drug Development Collaborative (DDC) brings projects to the Core for consideration. The DDC (chaired by Drs. Patricia Steeg and Doug Figg) is a steering committee that provides CCR investigators with assistance in their projects to support pre-clinical development. Projects presented by the DDC are typically in need of re-synthesis or simple medicinal chemistry that will allow the project to move forward in development. Before the Core agrees to undertake the project, the PI presents the project formally to the synthesis team to define the chemistry, synthetic feasibility, cost, time-to-completion, and alternate commercial/ vendor options. Prior to the PI meeting, the synthetic team will have already determined a proposed synthesis and/or explored vendor options. During the PI meeting, a decision is made as to whether or not the Core will undertake the project or recommend an alternate approach. The scope of a particular project is contextual. Some projects are simply "synthesis for hire" and others are more collaborative in nature and involve co-authoring publications. Joel Schneider actively manages projects. Core group meetings are held in Frederick once a week to discuss progress, troubleshoot chemistry and review analytical data. When needed, Drs. Jay Schneekloth and Martin Schnermann are consulted to develop synthetic strategy. Both PIs have exceptional training in synthetic methodology and natural product synthesis.

通常，需要帮助的 PI 或药物开发合作组织 (DDC) 会将项目提交给核心进行考虑。 DDC（由 Patricia Steeg 博士和 Doug Figg 博士担任主席）是一个指导委员会，为 CCR 研究人员的项目提供协助，以支持临床前开发。 DDC 提出的项目通常需要重新合成或简单的药物化学，以使项目能够继续发展。在核心同意承担该项目之前，PI 将项目正式提交给合成团队，以定义化学成分、合成可行性、成本、完成时间和替代商业/供应商选项。在 PI 会议之前，综合团队将已经确定了拟议的综合和/或探索了供应商选项。在 PI 会议期间，将决定核心是否承担该项目或推荐替代方法。特定项目的范围是根据具体情况而定的。有些项目只是“雇佣综合”，而另一些项目本质上更具协作性，涉及共同撰写出版物。乔尔·施奈德 (Joel Schneider) 积极管理项目。核心小组会议每周在弗雷德里克举行一次，讨论进展情况、解决化学问题并审查分析数据。当需要时，博士。咨询 Jay Schneekloth 和 Martin Schnermann 来制定合成策略。两位 PI 都接受过合成方法学和天然产物合成方面的特殊培训。