University of Texas Adult Clinical Center

德克萨斯大学成人临床中心

基本信息

批准号：
10265119
负责人：
Nicolas Musi
金额：
$ 3.59万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-12-07 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265119
关键词：
Acute Adherence Adipose tissue Adult Aerobic Aging American Biology Biopsy Biopsy Specimen Blood Body Composition Capsicum Catchment Area Chronic Chronic Disease Clinical Clinical Protocols Clinical Research Clinical Trials Clinical Trials Design Communities Complex Data Data Analyses Data Set Development Diabetes Mellitus Enrollment Environment Evidence based intervention Exercise Exercise Physiology Exercise Tolerance FRAP1 gene Funding Glucose Intolerance Goals Health Health Benefit Health Sciences Hispanics Human Human Resources Individual Industry Infrastructure Insulin Resistance Knowledge Latino Link Manuals Mediator of activation protein Medical Metabolic Metabolic Control Metabolic syndrome Methodology MicroRNAs Mission Molecular Molecular Profiling Multicenter Trials Multiomic Data Muscle Outcome Participant Pathway interactions Phase Phenotype Physical Performance Physical activity Physiological Population Protocols documentation Public Health Randomized Research Research Personnel Resource Sharing Resources Science Skeletal Muscle Source Specific qualifier value Texas Tissues Training Transducers United States National Aeronautics and Space Administration United States National Institutes of Health Universities base bone health clinical center cohesion cohort data integration design disability disability burden exercise training experience improved innovation metabolic abnormality assessment muscle strength novel operation participant retention preclinical study programs protein metabolite recruit research facility response sedentary strength training study population success tool

项目摘要

PROJECT SUMMARY The University of Texas Medical Branch at Galveston (UTMB) and the University of Texas Health Science Center at San Antonio (UTHSCSA) jointly propose the creation of a University of Texas Adult Clinical Center (UTACC) for the Molecular Transducers of Physical Activity Consortium (MoTrPAC). We will integrate resources and combine our expertise to provide a state-of-the-art center for comprehensive studies on physical activity in adults. The Specific Aims of the UTACC are: 1) To participate in the planning of the multi-center trial; 2) To enroll 450 participants in the acute and chronic exercise training studies, conduct physiological assessments, and collect biospecimens (muscle, adipose, and blood); and 3) To analyze and interpret outcome data and disseminate findings to the scientific community. We will use innovative tools to maximize participant retention and enhance fidelity and adherence to the exercise training protocols. The UTACC will have a significant impact on the MoTrPAC – and advance the field of exercise science – based on our strengths, feasibility of the proposed study, and expected outcomes: The strengths of the UTACC include our long-track record of performing human studies on molecular transducers of exercise; shared resources and years of networking through the Claude D. Pepper Older Americans Independence Center network and the Texas Regional CTSA Consortium; and our success with enrolling understudied populations such as older individuals and Hispanics-Latinos. The feasibility for the UTACC is high due to our experience with clinical trials on physical activity; our substantial expertise in collecting muscle and adipose biopsies in humans undergoing exercise studies; and our access to outstanding clinical research facilities in which to conduct human research in a safe environment. Expected outcomes of this program include the determination of baseline molecular signatures associated with metabolic health and physical performance; the integration of multi-omic data for the elucidation of molecular networks that control metabolic responses to exercise and how they influence physical performance; and discovery of novel mediators (proteins, metabolites, miRNAs) of the beneficial effects of exercise.

项目概要德克萨斯大学加尔维斯顿医学分校 (UTMB) 和德克萨斯大学健康科学学院圣安东尼奥中心 (UTHSCSA) 联合提议创建德克萨斯大学成人临床中心身体活动联盟分子传感器中心 (UTACC) (MoTrPAC)。我们将整合资源，结合我们的专业知识，为客户提供最先进的中心 UTACC 的具体目标是： 1) 2) 招募450名急性和慢性参与者运动训练研究、进行生理评估并收集生物样本（肌肉、脂肪、和血液）；以及 3）分析和解释结果数据并将研究结果传播给科学界我们将使用创新工具来最大限度地保留参与者并提高保真度和遵守运动训练协议。 UTACC 将对 MoTrPAC 产生重大影响，并推动运动科学领域的发展根据我们的优势、拟议研究的可行性以及预期结果： UTACC 的优势包括我们在分子生物学方面进行人体研究的长期记录。运动传感器；通过 Claude D. Pepper Older 共享资源和多年的网络美国独立中心网络和德克萨斯地区 CTSA 联盟以及我们的成功；招募未被充分研究的人群，例如老年人和西班牙裔拉丁裔。由于我们在体力活动临床试验方面的经验，UTACC 的可行性很高；在收集正在进行运动研究的人体肌肉和脂肪活检方面拥有丰富的专业知识；以及我们拥有出色的临床研究设施，可以在安全的环境下进行人体研究环境。该计划的预期结果包括确定相关的基线分子特征与代谢健康和身体表现相结合；整合多组学数据以阐明控制运动代谢反应的分子网络及其如何影响身体性能；以及新介质（蛋白质、代谢物、miRNA）的发现锻炼。