B WELL MOM ADHESION ANALYSIS

B WELL MOM 粘附力分析

• 批准号: 10263594
• 负责人: MICHAEL TSAI
• 金额: $ 26.63万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-23 至 2021-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263594
• 关键词: Adhesions; Asthma; Blood specimen; Caffeine; Environment; First Pregnancy Trimester; Genetic; Life Style; Measures; Nose; Personal Satisfaction; Plasma; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; RNA; Respiratory physiology; Risk Factors; Role; Serum; Specimen; Swab; Tissues; Umbilical Cord Blood; Urine; Vascular Endothelial Growth Factors; Visit; Woman; microbiome; pregnancy immunology; recruit; social health determinants

The purpose of the Breathe – Wellbeing, Environment, Lifestyle and Lung Function Study (B-WELL Mom Study) is to examine the role of asthma control in pregnancy outcomes. This study examines poor asthma control in the context of the immunology of pregnancy and risk factors such as genetics, the environment, and social determinants of health. Women with and without asthma were recruited during the first trimester of pregnancy (< 15 weeks gestation) and followed through 4 months post-partum. Assessments occurred during each trimester of pregnancy (<15 weeks, 20-22 weeks, 30-32 weeks), at delivery, and 4 months post-partum. The B-WELL Mom study collected urine, microbiome swabs, and blood samples (PAXGene RNA, serum, plasma, and buffy coat) from approximately 400 subjects at each visit (<15 weeks, 20-22 weeks, 30-32 weeks) and 4 months post-partum. Nasal swabs were collected once during pregnancy, and placental tissue specimens and cord blood RNA were collected at delivery.

呼吸——健康、环境、生活方式和肺功能研究（B-WELL Mom 研究）的目的是检查哮喘控制在妊娠结局中的作用。该研究在妊娠免疫学和风险的背景下检查哮喘控制不良。遗传、环境和健康的社会决定因素等因素。 患有和不患有哮喘的女性在怀孕的前三个月（妊娠<15周）期间被招募，并在妊娠的每个三个月（<15周、20-22周、30-32周）期间进行评估。 、分娩时和产后 4 个月。 B-WELL Mom 研究每次访视（<15 周、20-22 周、30-32 周）时收集了约 400 名受试者的尿液、微生物组拭子和血液样本（PAXGene RNA、血清、血浆和血沉棕黄层），产后4个月，孕期采集一次鼻拭子，分娩时采集胎盘组织标本和脐带血RNA。