Unpacking the Importance of the Structural Injuries of MTBI

揭示 MTBI 结构性损伤的重要性

基本信息

批准号：
10263451
负责人：
Sohae Chung
金额：
$ 59.33万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2021-08-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10263451
关键词：
Affect Animals Anisotropy Attention Axon Behavioral Benchmarking Biophysics Brain Brain Injuries Cells Clinical Cognition Cognitive Complex Confusion Corpus Callosum Diffuse Diffusion Diffusion Magnetic Resonance Imaging Disease Elements Evolution Fiber Goals Human Image Impaired cognition Incidence Injury Investigation Knowledge Link Literature Magnetic Resonance Imaging Measures Mediating Modeling Neurobehavioral Manifestations Outcome Pathology Patient Triage Patient-Focused Outcomes Patients Population Process Protocols documentation Public Health Risk Rotation Scheme Short-Term Memory Standard Model Stretching Structure Symptoms TBI Patients Techniques Testing Therapeutic Tissues Torsion Translating Water Work axon injury base behavioral health biomechanical model biophysical properties clinically significant cognitive function cognitive rehabilitation disabling symptom experience head impact human model imaging biomarker in vivo injury recovery innovation mild traumatic brain injury novel oculomotor persistent symptom processing speed rate of change white matter white matter injury

项目摘要

PROJECT SUMMARY Mild Traumatic Brain Injury (MTBI) is a major public health problem with U.S. annual incidence of over 2 million. We propose to use an innovative paradigm in bicompartment diffusion MRI model parameter estimation to study the dynamic longitudinal microstructural changes that occur after MTBI and to investigate the link between white matter injury, cortical volume loss and cognitive outcome. Our preliminary findings suggest diffusion-based biophysical parameters of axon integrity including intra-axonal diffusivity (Da) and axonal water fraction (f) can detect microstructure changes in MTBI and provide more biophysically relevant information compared with traditional, empirical measures of Diffusion Tensor Imaging (DTI). We will employ a rotationally invariant formalism and parameter estimation scheme for the so-called “Standard Model” of diffusion in white matter which unifies previous attempts of multi-compartment white matter modeling over the past decade, now a widely accepted benchmark for multi-compartment modeling of diffusion in the brain. We will further incorporate spherical tensor encoding (STE) to increase the precision in axon-specific microstructure parameters central to this project and use an optimized and clinically feasible protocol for this translational project. The proposed work is expected to bridge the gap between macroscopic and microstructural alterations relevant to cognitive status after injury, revealing the dynamic structural changes occurring after injury and pointing to imaging biomarkers most relevant to cognitive outcome. The results of this work are expected to be significant from both scientific and clinical perspectives by 1) advancing basic knowledge of injury in an impactful way, 2) discovering biophysically meaningful imaging biomarkers relevant to cognitive status in MTBI, and 3) mechanistically linking microstructural and macrostructural brain alterations, in three respective specific aims. This will provide a means toward quantitative tracking of injury and recovery in the cognitive domain, and tracking of efficacy of targeted cognitive therapeutic strategies such as cognitive rehabilitation and integrated behavioral health treatment in patients with MTBI.

项目摘要轻度创伤性脑损伤（MTBI）是美国年度发病率超过2的主要公共卫生问题百万。研究MTBI之后发生的动态纵向微神经变化的估计并研究白质损伤，皮质量损失和认知结果之间的联系建议轴突完整性 - 轴内扩散率（DA）的扩散生物物理参数和轴突水分（F）可以检测MTBI的微观结构变化，并提供更相关的相关性与传统的扩散张量成像（DTI）相比，我们将采用一个。所谓的“标准模型”的旋转形式主义和参数方案白质白色的扩散统一了多室白质建模的先前尝试过去的十年，现在广泛接受的基准，用于大脑中扩散的多室建模将进一步纳入球形张量编码（Ste），以提高轴突特异性的精度项目中心的微观结构参数并使用开放。翻译项目。受伤后与认知状况相关的微观结构变化，陶醉于动态结构的变化发生在受伤后并指出与认知结果最相关的生物标志物。从科学和临床的角度来看，预计工作将具有重要意义以有影响力的方式了解伤害在MTBI中的认知状态，以及3）机械师将微观结构和重大脑的改变联系起来，在各自的特定目的中在认知领域，并跟踪有针对性的认知疗法策略，例如认知策略 MTBI患者的康复和综合行为健康治疗。