"Blueprint of Life" Genomic Literacy Tool: An interactive to enhance genetic and genomic understanding with middle/high school students and their teachers through personal genetics and human disease

“生命蓝图”基因组素养工具：通过个人遗传学和人类疾病，与中/高中生及其老师增强遗传和基因组理解的互动工具

• 批准号: 10258095
• 负责人: Sally Reidy
• 金额: $ 92.38万
• 依托单位: D'VINCI INTERACTIVE, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258095
• 关键词: 3-Dimensional; Achievement; African American; Attitude; Behavior Therapy; Behavioral Sciences; Biomedical Research; Breathing; COVID-19 pandemic; Case Study; Chronic Disease; Collaborations; Control Groups; Country; Critical Thinking; Demographic Factors; Development; Distance Learning; E-learning; Education; Educational Curriculum; Educational Intervention; Elements; Ensure; Environment; Ethics; Evaluation; Female; Fibrinogen; Future; Genetic; Genetic Diseases; Genetic Enhancement; Genetic Medicine; Genetic Research; Genome; Genomics; Goals; Growth; Health; Healthcare; High School Student; Hispanic Americans; Human; Imagery; Immersion; Intervention; Knowledge; Language; Learning; Life; Measures; Minority; Modernization; Molecular Genetics; Motivation; National Institute of General Medical Sciences; Native Americans; Next Generation Science Standards; Outcome; Participant; Performance; Personal Satisfaction; Phase; Prevalence; Prevention; Randomized Controlled Trials; Readiness; Reporting; Research; STEM career; Schools; Science; Science of genetics; Science, Technology, Engineering and Mathematics Education; Scientist; Small Business Innovation Research Grant; Societies; Students; System; Technology; The Jackson Laboratory; Time; Underserved Population; Viral Genome; Woman; Work; adaptive learning; base; bioinformatics tool; career; dashboard; design; digital; experience; genome sciences; high school; human disease; improved; innovation; interactive tool; interest; junior high school; learning ability; literacy; male; next generation; ninth grade; online classroom; pandemic disease; personalized medicine; prototype; psychologic; racial diversity; racial minority; role model; school district; skills; student training; teacher; tool; treatment group; underserved students; virtual; virtual laboratory

The increasing prevalence of genetics and genomics information in modern life calls for an equally relevant and engaging solution to teach the next generation. Additionally, educational interventions that help close the participation and achievement gap of underrepresented demographic groups in STEM are sorely needed. In this NIGMS Phase II SBIR project, d’Vinci Interactive, in collaboration with The Jackson Laboratory, proposes to develop and evaluate a full-function prototype of the “Blueprint of Life” online educational solution, which is aimed at embedding genomics into middle school and high school classrooms. The solution will feature an expanded, NGSS-aligned supplemental curriculum that teaches key concepts around molecular genetics of personalized medicine, use of bioinformatics tools, the viral genome (particularly with regard to the COVID-19 pandemic), careers in genetics science, and the ethics of genetics research. The curriculum will be delivered via an online student learning portal designed to provide learning experiences that are engaging, inspirational, accessible, inclusive, and relevant to students’ lives, with features such as an immersive 3D/VR genome exploration module and an immersive Virtual Laboratory environment (which together represent the core of the project’s technical innovation), creative content that appeals to underrepresented demographic groups, a Spanish-language curriculum version, and adaptive learning technology. Educators will have access to a Learning Management System, online classroom tools that are easy to implement both virtually and in-class, and an Administrative Dashboard for real-time school and school-district level reporting on student learning progress. The aims for this Phase II project are to show that the solution delivers the following learner benefits: (1) effective mastery of the fundamentals of genomics/genetics and personalized medicine, (2) effective understanding of the ethical and healthcare implications of genetics/genomics, (3) motivational impact on students, by promoting interest in genomics/STEM education and careers, (4) strong learning and motivational impact on underrepresented demographic groups. WestEd, will conduct To verify the attainment of these aims, the external research and evaluation partner, a Randomized Controlled Trial (with 750 9th grade students from classrooms with high populations of underserved students) on the fully developed educational solution. Aims 1-3 are supported if students in the treatment group show a pre- versus post-assessment performance improvement (measured in terms of information retention (Aim 1), attitudes towards the practical use of science (Aim 2), and interest in pursuing additional genomics/STEM education and a genomics/STEM career (Aim 3)) that is statistically larger than the improvements observed in the control group. Aim 4 is supported if performance in the treatment group is uncorrelated with demographic factors (i.e. males vs. females and minority vs. non-minority students). Overall, the engaging and inspirational learning solution proposed in this project will help better prepare tomorrow’s healthcare consumers and scientists and promote greater diversity in STEM education and practice.

现代生活中遗传学和基因组信息的普遍性日益普遍，需要同样相关和 吸引解决下一代的解决方案。此外，有助于关闭的教育干预措施 迫切需要STEM中代表性不足的人群群体的参与和成就差距。在这个 NIGMS II阶段SBIR项目，D'Vinci Interactive，与杰克逊实验室合作，提案 开发和评估“生活的蓝图”在线教育解决方案的全功能原型，该解决方案的目标 将基因组学嵌入中学和高中教室。该解决方案将具有扩展的， NGSS与一致的补充课程教授围绕个性化分子遗传学的关键概念 医学，生物信息学工具的使用，病毒基因组（部分是关于COVID-19的大流行）， 遗传学科学的职业和遗传学研究的伦理。该课程将通过在线提供 学生学习门户网站旨在提供吸引人，鼓舞人心，易于访问的学习经验 包容性，与学生的生活有关，具有沉浸式3D/VR基因组探索模块之类的功能 以及沉浸式虚拟实验室环境（共同代表了项目技术的核心 创新），创意内容似乎不足以代表性的人群群体，这是一个西班牙语 课程版本和自适应学习技术。教育工作者将可以使用学习管理 系统，易于实施的在线课堂工具，以及管理 实时学校和学校分区水平的仪表板报告学生学习进度。目的 第二阶段项目表明该解决方案为以下学习者带来了好处：（1）有效掌握 基因组学/遗传学和个性化医学的基本原理，（2）有效理解道德和 遗传学/基因组学对医疗保健的影响，（3）通过促进对学生的动机影响 基因组学/STEM教育和职业，（4）对代表性不足的强大学习和动机影响 人口群体。 向西，将进行 为了验证这些目标的属性，外部研究和评估伙伴， 一项随机对照试验（有750名9年级的学生来自教室 在全面发展的教育解决方案上，服务不足的学生人数。 AIMS 1-3得到支持如果 治疗组的学生表明，在评估后的表现改善（以 信息保留条款（AIM 1），关注科学的实际使用（AIM 2），并对 从统计上更大 比对照组观察到的改进。 AIM 4如果在治疗组中的表现支持 与人口统计学因素（即男性与少数民族与非少数学生）无关。全面的， 该项目提出的引人入胜且鼓舞人心的学习解决方案将有助于更好地准备明天的 医疗保健消费者和科学家，并在STEM教育和实践中促进更大的多样性。