Per- and Polyfluoroalkyl substances (PFAS) Exposures and COVID-19 in Firefighters

消防员中的全氟烷基物质和多氟烷基物质 (PFAS) 暴露和 COVID-19

• 批准号: 10256062
• 负责人: Jefferey L. Burgess
• 金额: $ 15.01万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-08 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10256062
• 关键词: 19 year old; 2019-nCoV; Adult; Alkanesulfonates; Antibodies; Antibody Response; Antibody titer measurement; Arizona; Biological; Blood; COVID-19; COVID-19 patient; COVID-19 severity; COVID-19 vaccine; Cessation of life; Child; Communicable Diseases; Coronavirus; Coughing; Diagnostic tests; Diphtheria; Disease; Elderly; Enrollment; Exposure to; Fever; Fire - disasters; General Population; Goals; Health; Hospitalization; Immune response; Immunity; Immunoglobulin G; Immunoglobulin M; Individual; Infection; Isomerism; Life; Linear Regressions; Maternal Exposure; Measurable; Measures; Medical; Modeling; Mumps; Nature; Nose; Outcome; Pilot Projects; Population; Postdoctoral Fellow; Prospective cohort; Publishing; Recovery; Registries; Reporting; Research; Risk; Risk Factors; Rubella; SARS coronavirus; SARS-CoV-2 immune response; SARS-CoV-2 infection; Secondary Immunization; Serology; Serum; Severe Acute Respiratory Syndrome; Severities; Surveys; Symptoms; Testing; Tetanus; Time; Virus; antibody test; asymptomatic COVID-19; fire fighter; ground water; high risk; innovation; male; pandemic disease; perfluorohexane; programs; recruit; respiratory; response; sample collection; symptomatic COVID-19

PROJECT SUMMARY/ABSTRACT The spread of SARS-CoV-2 infection and its associated disease state, COVID-19, has led to a global pandemic. Exposure to per- or polyfluoroalkyl substances (PFAS) is associated with reduced immune response, but its effect on COVID-19 is not known. We have a time-sensitive opportunity to determine the effect of serum PFAS on COVID-19, building on a unique statewide firefighter testing program for SARS-CoV-2 antibodies. Our long- term goal is to identify health risks of PFAS mixtures. Our objective in this application is to evaluate the effects of PFAS exposure levels in firefighters in regards to the severity of and immune response to COVID-19 infection. Our hypotheses are that increased PFAS serum concentrations will increase the severity of COVID-19 infection and reduce post-recovery serologic titers, which could thereby increase risk of later re-infection. We will test these hypotheses through two specific aims: 1) Determine the association of serum PFAS concentrations with infection severity; and 2) Determine the association of serum PFAS with SARS-CoV-2 antibody titers. For aim 1, recruiting from our state registry, we will enroll 100 Tucson and Phoenix firefighters with positive SARS-CoV- 2 IgM and/or IgG antibodies, and collect and analyze their serum for PFAS. Using an online survey instrument completed at the time of biological sample collection, we will obtain information on whether the subjects had COVID-19 infection(s) confirmed by diagnostic testing, extent of symptoms (if any) consistent with COVID-19 infection, and whether they were hospitalized. We will evaluate the association between serum PFAS and: 1) severity of symptoms; 2) symptomatic vs. asymptomatic COVID-19 infection; and 3) hospitalization. For aim 2, we will repeat SARS-CoV-2 IgG testing after five months and ten months in all firefighters enrolled in the study to measure changes in immune response and to test the association of PFAS levels and longitudinal changes in IgG using generalized linear regression models that account for repeated measures. At study completion, we will have documented the effects of PFAS exposure on the likelihood of a symptomatic COVID-19 infection and symptom severity in a highly exposed population, as well as effects of PFAS exposure on the subsequent immune response persistence. The proposed research is significant given the potential for PFAS exposure to increase the risk of already severe health consequences of COVID-19 and to reduce long-term immune response. The proposed research is innovative as it is the first to our knowledge to determine the association between serum PFAS levels and COVID-19.

项目概要/摘要 SARS-CoV-2 感染及其相关疾病 COVID-19 的传播已导致全球大流行。 暴露于全氟烷基物质或多氟烷基物质 (PFAS) 与免疫反应降低有关，但其 对 COVID-19 的影响尚不清楚。我们有一个时间敏感的机会来确定血清 PFAS 的效果 关于 COVID-19，以独特的全州消防员 SARS-CoV-2 抗体测试计划为基础。我们的长期 长期目标是确定 PFAS 混合物的健康风险。我们在此应用程序中的目标是评估效果 消防员的 PFAS 暴露水平与 COVID-19 感染的严重程度和免疫反应有关。 我们的假设是，PFAS 血清浓度增加会增加 COVID-19 感染的严重程度 并降低恢复后的血清滴度，从而增加以后再次感染的风险。我们将测试 这些假设有两个具体目标：1) 确定血清 PFAS 浓度与 感染严重程度； 2) 确定血清 PFAS 与 SARS-CoV-2 抗体滴度的关联。为了目标 1、从我们的州登记处招募 100 名 SARS-CoV 呈阳性的图森和菲尼克斯消防员 2 IgM 和/或 IgG 抗体，收集并分析其血清中的 PFAS。使用在线调查工具 在生物样本采集时完成，我们将获得有关受试者是否患有 通过诊断测试确认的 COVID-19 感染，症状程度（如果有）与 COVID-19 一致 是否感染，以及是否住院。我们将评估血清 PFAS 与以下因素之间的关联：1) 症状的严重程度； 2) 有症状与无症状的 COVID-19 感染； 3) 住院治疗。对于目标 2， 我们将在五个月和十个月后对参与该研究的所有消防员重复进行 SARS-CoV-2 IgG 测试 测量免疫反应的变化并测试 PFAS 水平和纵向变化的关联 在 IgG 中，使用考虑重复测量的广义线性回归模型。研究完成时，我们 将记录 PFAS 暴露对有症状的 COVID-19 感染可能性的影响，并且 高暴露人群的症状严重程度，以及 PFAS 暴露对后续的影响 免疫反应的持续性。鉴于 PFAS 暴露于以下环境的可能性，拟议的研究具有重要意义： 增加 COVID-19 造成本已严重的健康后果的风险，并降低长期免疫能力 回复。拟议的研究具有创新性，因为这是据我们所知第一个确定关联的研究 血清 PFAS 水平与 COVID-19 之间的关系。