Core Research Services for Molecular Imaging and Imaging Sciences

分子成像和成像科学的核心研究服务

• 批准号: 10255331
• 负责人: Joseph Frank
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10255331
• 关键词: Academic Training; Atherosclerosis; Basic Science; Biology; Chemistry; Clinical; Clinical Sciences; Colonic Polyps; Confocal Microscopy; Contrast Media; Core Facility; Development; Diagnostic radiologic examination; Doctor of Philosophy; Emission-Computed Tomography; Equipment; Goals; Image; Infrastructure; Integrins; Intervention; Intramural Research Program; Laboratories; Liposomes; Magnetic Resonance Imaging; Metabolic; Methods; Microscopy; Molecular; Molecular Biology; Multimodal Imaging; Pathologic; Positron-Emission Tomography; Radioactive; Radiology Specialty; Research; Research Personnel; Resources; Rodent Model; Science; Scientist; Services; Structure; Synthesis Chemistry; System; Training; Training Programs; Translational Research; X-Ray Computed Tomography; cell motility; clinical center; image guided intervention; imaging scientist; in vivo; microPET; molecular imaging; multidisciplinary; multimodality; nanoparticle; novel diagnostics; novel therapeutics; programs; radiological imaging; radiologist; stem cells; tissue culture; trafficking

The core facilities support translational research in the imaging sciences. Radiology and Imaging Sciences has evolved over the years. Supporting imaging research with core facilities and training academic radiologists and imaging scientists in the Intramural Program is the main goal. The Laboratory for Diagnostic Radiology Research has evolved into a more broad program for core support of translational research related to Radiology and Imaging Sciences, maintaining infrastructure for core basic science radioactive and non-radioactive lab facilities in Radiology with biology, molecular biology bays, synthetic chemistry bays, in vivo and ex vivo microscopy, BSL 2 tissue culture rooms, cold rooms, confocal microscopy, in vivo microscopy, contrast agent development, stem cell trafficking, cell migration, nanoparticle analysis and characterization, integrin antagonist synthetic chemistry, multi-modality probes, atherosclerosis probes, molecular imaging of colonic polyps, multi-modality imaging, molecular interventions, and liposomal chemistry. The core facility also now operates a micro-positron emission tomography (PET) and micro-computerized tomography (CT) system for performing PET/CT evaluating structural and metabolic changes in rodent models. There is also a 7T MRI Microimager and 3T clinical MRI scanner available to the scientists. There is a variety of shared equipment and facilities in the department that supports Radiology and Imaging Sciences Investigators and collaborative Intramural Investigators and labs, as well as the training of junior clinical, translational and basic science investigators.

核心设施支持成像科学中的转化研究。 多年来，放射学和成像科学一直在发展。主要目标是通过核心设施和培训学术放射科医生和成像科学家的培训的成像研究。 The Laboratory for Diagnostic Radiology Research has evolved into a more broad program for core support of translational research related to Radiology and Imaging Sciences, maintaining infrastructure for core basic science radioactive and non-radioactive lab facilities in Radiology with biology, molecular biology bays, synthetic chemistry bays, in vivo and ex vivo microscopy, BSL 2 tissue culture rooms, cold rooms, confocal显微镜，体内显微镜，对比剂的发育，干细胞运输，细胞迁移，纳米颗粒分析和表征，整联蛋白拮抗剂合成化学，多模式探针，动脉粥样硬化探针，结肠息肉的分子成像，多模式成像，多模式成像，分子干预措施，分子干预措施和Lipsosal Chemical。现在，核心设施还运行微型符号发射断层扫描（PET）和微型计算机层析成像（CT）系统，用于对啮齿动物模型中的结构和代谢变化进行PET/CT进行评估。科学家还提供了7T MRI MIRI MICRAIMIMAGER和3T临床MRI扫描仪。该部门有各种各样的共享设备和设施，这些设备和设施支持放射学和成像科学研究人员以及合作的壁内研究人员和实验室，以及对初级临床，转化和基础科学研究者的培训。