ETHNIC DIFFERENCES IN ACUTE PAIN AND ANALGESIC RESPONSE

急性疼痛和镇痛反应的种族差异

• 批准号: 7950742
• 负责人: BARBARA A HASTIE
• 金额: $ 0.18万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950742
• 关键词: Absence of pain sensation; Acute; Acute Pain; Adverse effects; Age; Analgesics; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Kinetics; Ethnic group; Fentanyl; Funding; Genetic; Goals; Grant; Hour; Individual; Institution; Measures; Minority; Modeling; Monitor; Opioid; Pain; Patients; Perception; Pharmacodynamics; Physiological; Postoperative Pain; Procedures; Psychophysiology; Psychosocial Factor; Quality of life; Research; Research Design; Research Personnel; Resources; Source; Translational Research; United States National Institutes of Health; biopsychosocial; ethnic difference; health disparity; psychosocial; response; therapy design; third molar extraction

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use a common acute clinical pain model to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and to examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and will examine genetic, pharmacokinetic, pharmacodynamic, and psychosocial factors that explain group differences in analgesic responses. 300 minority and white patients age range 18-who undergo third molar extraction will be included in this study. Preoperative experimental pain responses and psychosocial measures will be assessed and postoperative pain levels along with pharmacokinetic; and pharmacodynamic responses to the opioid fentanyl will be monitored. Group differences in post-operative pain as well as analgesic responses immediately and for several hours post-operatively and up to 3 days post-procedure will also be assessed. The long-term goal of this study is to develop a programmatic line of research designed to elucidate biopsychosocial contributions to ethnic differences in pain and to eventually engage in translational research to reduce health disparities in clinical pain through the development of interventions designed to enhance the quality of life of individuals with pain.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究将使用常见的急性临床疼痛模型来识别和表征导致疼痛感知和镇痛方面种族差异的社会心理、生理和遗传因素。 目标 1 将确定种族群体对术后急性疼痛的感知和生理反应的差异，并研究这些差异与遗传、术前心理物理和心理社会因素的关系。 目标 2 将确定阿片类镇痛和副作用的种族差异，并将检查解释镇痛反应的群体差异的遗传、药代动力学、药效学和心理社会因素。 本研究将纳入 300 名年龄在 18 岁之间接受第三磨牙拔除的少数族裔和白人患者。 将评估术前实验性疼痛反应和心理社会测量，并评估术后疼痛水平以及药代动力学；并将监测对阿片类药物芬太尼的药效反应。 还将评估术后疼痛以及术后立即、术后数小时和术后 3 天的镇痛反应的组间差异。 本研究的长期目标是开发一系列研究计划，旨在阐明生物心理社会对疼痛种族差异的影响，并最终进行转化研究，通过开发旨在提高疼痛质量的干预措施来减少临床疼痛的健康差异。患有痛苦的人的生活。