CRST COVID-19 - Wayakta He

基本信息

批准号：
10250814
负责人：
Esther Erdei
金额：
$ 21.75万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10250814
关键词：
2019-nCoV Address Affect Age Air Alaska Native American Indians Attention Biomedical Research Businesses COVID-19 COVID-19 detection COVID-19 diagnosis COVID-19 pandemic COVID-19 severity COVID-19 susceptibility Characteristics Cheyenne Collaborations Color Communities Complex Data Data Collection Development Disease Disease Outbreaks Disease susceptibility Economic Conditions Electronic cigarette Employment Environmental Health Environmental Pollution Environmental Risk Factor Ethnic group Exposure to Future Generations Grant Health Sciences Heating Home Home environment Household Housing Hydrocortisone Immune response Immunity Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunologics Individual Indoor Air Pollution Industry Inequality Infection Knowledge Lead Literature Low income Measures Missouri Native Americans New Mexico Nicotine Nitrogen Dioxide Paper Participant Personal Behavior Predisposition Prevalence Preventive measure Public Health Research Research Personnel Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Risk Risk Factors Rivers SARS-CoV-2 infection Sampling Severities Severity of illness Sioux Indians Social Environment Source South Dakota Structure Surveys Testing Time Toxic Environmental Substances Toxicant exposure Tribes Trust United States Indian Health Service Universities Viral Virus Diseases Work Youth air monitoring base cooking coronavirus disease design detection assay electronic cigarette use environmental justice environmental stressor environmental tobacco smoke ethnic minority population experience health disparity health literacy high risk improved innovation low socioeconomic status member minority communities novel pandemic disease pollutant population based psychosocial stressors racial and ethnic recruit response saliva sample salivary assay social factors socioeconomics stem stressor tribal Nation tribal community vaping

2019-nCoV Address Affect Age Air Alaska Native American Indians Attention Biomedical Research Businesses COVID-19 COVID-19 detection COVID-19 diagnosis COVID-19 pandemic COVID-19 severity COVID-19 susceptibility Characteristics Cheyenne Collaborations Color Communities Complex Data Data Collection Development Disease Disease Outbreaks Disease susceptibility Economic Conditions Electronic cigarette Employment Environmental Health Environmental Pollution Environmental Risk Factor Ethnic group Exposure to Future Generations Grant Health Sciences Heating Home Home environment Household Housing Hydrocortisone Immune response Immunity Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunologics Individual Indoor Air Pollution Industry Inequality Infection Knowledge Lead Literature Low income Measures Missouri Native Americans New Mexico Nicotine Nitrogen Dioxide Paper Participant Personal Behavior Predisposition Prevalence Preventive measure Public Health Research Research Personnel Research Project Grants Reverse Transcriptase Polymerase Chain Reaction Risk Risk Factors Rivers SARS-CoV-2 infection Sampling Severities Severity of illness Sioux Indians Social Environment Source South Dakota Structure Surveys Testing Time Toxic Environmental Substances Toxicant exposure Tribes Trust United States Indian Health Service Universities Viral Virus Diseases Work Youth air monitoring base cooking coronavirus disease design detection assay electronic cigarette use environmental justice environmental stressor environmental tobacco smoke ethnic minority population experience health disparity health literacy high risk improved innovation low socioeconomic status member minority communities novel pandemic disease pollutant population based psychosocial stressors racial and ethnic recruit response saliva sample salivary assay social factors socioeconomics stem stressor tribal Nation tribal community vaping

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项目摘要

Title: CRST COVID-19 Wayakta He? (Are you on guard against COVID?) PI: E. Erdei Project Summary Ongoing concurrent pandemics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections and toxic exposures originated from electronic cigarette (e-cig) and secondhand smoke had taken devastating tolls on minority communities in the U.S. Rather than being “the great equalizer” due to universal lack of immunity, evidence has shown that the burden of COVID-19 disease has been disproportionately felt by racial/ethnic minority and low-income communities. This stark and most current health disparity is likely due to a variety of psychosocial stressors stemming from structural inequalities that place individuals of color and/or low socioeconomic status, including American Indian/Alaska Native communities at greater risk for the contraction of SARS-CoV-2 infection and severity of COVID-19 disease. A recent literature showed that overall COVID-19 diagnosis was associated with youth use of e-cigarettes. However, that study did not look specifically at younger generation of American Indian and Alaskan Native (AI/AN), and how other factors within tribal communities affect disease susceptibility. This proposal is submitted in response to "Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences ", RFA-ES-19-011. Aim 1 will employ a community-based data collection of socioeconomic and environmental stressors in the Cheyenne River Sioux Tribal (CRST) communities in South Dakota by administering a tribal-specific survey, which will constitute the CRST SARS-CoV-2 infection prevalence collected in 300 participating CRST households with 600 distinct participants representing a wide-range of ages (18-89 yrs). The development of novel and time - sensitive data during the ongoing CRSRT pandemic on social factors and environmental toxicants will expand under Aim 2 by capturing detailed personal behaviors (i.e. vaping), stressors, Tribal housing, and by measuring environmental health factors that may impact COVID-19 disease susceptibility, severity and immune response. Detailed immunological assessment (total IgA, viral-specific IgG & IgM positivities and cortisol) will be carried out by using non-invasive saliva sampling. These measures will help us to assess the association between risk factors from Aim 1 survey data and RT-PCR confirmed SARS-CoV-2 viral infection prevalence. Based on passive air monitoring we will be able to evaluate the association between airborne exposures to nitrogen dioxide and airborne nicotine in the homes with increased susceptibility for SARS-CoV-2 infections and increased viral-specific IgM and decreased protective IgG response. We will assist CRST COVID-19 Command Center by generating a community-driven, COVID-19 targeted, public health literacy, and by capturing population-based infection susceptibility risks and specific immune response data. Our hypothesis is that increased SARS-CoV-2 infections among CRST community members are associated with vaping and indoor secondhand smoke, lower socioeconomic status, the type of heating sources used in homes, large multigenerational households (>3.4 people in one home), and living in multi-unit Tribal housing complexes.

标题：CRST COVID-19 WAYAKTA他？（您是否在警惕Covid？）PI：E。Erdei 项目摘要严重急性呼吸综合征冠状病毒2（SARS-COV-2）的持续同时发生感染和有毒暴露起源于电子烟（E-cig）和二手烟对美国的少数民族社区造成了毁灭性的通行费缺乏免疫力，有证据表明，Covid-19疾病的燃烧被不成比例地感受到种族/族裔少数民族和低收入社区。这种鲜明的和大多数当前的健康差异可能是由于由结构性不平等引起的各种社会心理压力源，这些不平等现象和/或低社会经济地位，包括美洲印第安人/阿拉斯加的本地社区，面临更大风险 SARS-COV-2感染和COVID-19疾病的严重程度的收缩。最近的文献表明总体Covid-19诊断与青年使用电子烟有关。但是，这项研究没有看特别是在年轻一代的美洲印第安人和阿拉斯加本地人（AI/AN），以及内部其他因素部落社区影响疾病的敏感性。该建议是根据“机制的环境健康科学的时间敏感研究机会”，RFA-ES-19-011。AIM 1将员工夏安的社会经济和环境压力源的基于社区的数据收集南达科他州的苏州河部落（CRST）社区通过进行特定于部落的调查，该调查将构成300个参与CRST家庭收集的CRST SARS-COV-2感染率 600名不同的参与者，代表广泛的年龄（18-89岁）。小说和时间的发展 - 正在进行的CRSRT大流行期间的敏感数据对社会因素和环境有毒物质将扩大在AIM 2下，通过捕获详细的个人行为（即vaping），压力源，部落住房以及测量可能影响199疾病易感性，严重程度和免疫响应的环境健康因素。将携带详细的免疫学评估（总IgA，病毒特异性IgG和IgM阳性和皮质醇）通过使用非侵入性唾液采样。这些措施将有助于我们评估风险之间的关联 AIM 1调查数据和RT-PCR的因素证实了SARS-COV-2病毒感染的患病率。基于被动空气监测我们将能够评估机载暴露与氮之间的关联房屋中的二氧化二氧化碳和空气传播尼古丁，对SARS-COV-2感染的敏感性增加病毒特异性IgM增加并减少受保护的IgG反应。我们将协助CRST COVID-19 指挥中心通过产生社区驱动的，COVID-19的目标，公共卫生素养，并通过捕获基于人群的感染易感性风险和特定的免疫响应数据。我们的假设是 CRST社区成员中SARS-COV-2感染的增加与烟有关室内二手烟，较低的社会经济状况，房屋中使用的供暖源类型，大型多代家庭（一个房屋中的3.4人），生活在多单元的部落住房综合体中。