Methodologic Core

方法论核心

基本信息

批准号：
10248404
负责人：
Michael J Econs
金额：
$ 38.96万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10248404
关键词：
Back Basic Science Big Data Bioinformatics Biometry Biostatistical Methods Characteristics Chronic Disease Classification Clinical Clinical Data Clinical Investigator Clinical Research Clinical Trials Design Collaborations Communication Communities Complex Computational Biology Computational algorithm Data Data Set Data Sources Databases Development Diagnosis Disease Distant Electronic Health Record Evaluation Functional disorder Funding Gastrointestinal tract structure Genetic Genomics Genotype Goals Health Health Care Costs Healthcare Systems Homeostasis Hormones Human Impairment Indiana Individual Information Technology Institutes Interdisciplinary Study Investigation Kidney Knowledge Discovery Lead Link Literature Mechanics Medical Medical Informatics Methodology Methods Minerals Modernization Molecular Morphology Multiomic Data Muscle Musculoskeletal Musculoskeletal Diseases Nervous system structure Organ Outcome Outcomes Research Pain Pathogenesis Patients Phenotype Physical Function Precision Health Prevention Process Proteomics Public Domains Publishing Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Support Resources Sampling Science Source Speed Standardization Statistical Data Interpretation Symptoms System Systems Biology Techniques Technology Technology Transfer Therapeutic Training Universities Work base bench to bedside biobank biological systems biomarker development biomarker discovery blood resource bone bone cell clinical center complex data computable phenotypes data integration design disability health information technology imaging modality improved industry partner innovation member metabolomics molecular phenotype multidisciplinary new technology new therapeutic target novel personalized medicine precision medicine prospective recruit sample collection success text searching tissue resource tool

项目摘要

Musculoskeletal disorders are common and result in significant disability and health care costs. Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The latter is critical to precision or personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and technology transfer and provide pilot funding to support new research. In the Methodologic Core, the ICCCR will train, facilitate and support investigators to expand access to biostatical support and project review, enhance clinical research and patient health by leveraging large databases to define and validate computable phenotypes, and accelerate the human to bench and back cycle of musculoskeletal discovery by assisting investigators in state of the art evaluation of musculoskeletal biospecimens. These new and innovative initiatives under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized medicine by focusing the right treatment for each patient.

肌肉骨骼疾病很常见，导致严重的残疾和医疗保健费用。诊断和治疗肌肉骨骼疾病的进步需要强大的临床研究基础架构和改善各种疾病的分类。后者对于精确或个性化医学方法，因为许多肌肉骨骼疾病都有常见的临床表现尽管病理生理多样化，疼痛和身体机能受损。此外，迄今为止的研究经常专注于骨头或肌肉，而不是它们相互作用的方式。印第安纳州核心中心的总体主题临床研究（ICCCR）是为了增强肌肉骨骼疾病的临床研究，并了解通过更好地定义或表型来进行这种广泛的疾病，以促进肌肉骨骨连接临床研究。 ICCCR将利用包括印第安纳州和普渡大学在内的CTSA的校园资源大学，我们的全州医疗保健系统IU Health，Regenstrief Institute的全州电子健康记录系统以及增强临床研究的精确健康计划。 ICCCR将与多学科研究人员的主题团队创建创新的方式来思考肌肉骨骼疾病表型。 ICCCR将支持个人将调查人员和主题团队与方法论和资源核心，从而促进访问并帮助进行研究1）我们庞大的电子健康记录，OMIC和生物信息学组的网络，以创建可计算的遗传和分子表型，2）发展标准化的身体功能和成像方式以发展功能性和形态学表型，以及3）扩展印第安纳生物银行的肌肉骨骼组织和血液资源。 ICCCR将与社区和行业合作伙伴合作，以促进招聘和技术转移并提供试点资金以支持新研究。在方法论核心中，ICCCR 将培训，促进和支持调查人员扩大获得生物统计支持和项目的访问通过利用大型数据库定义和验证可计算的表型，并加速人类的基准和背部周期肌肉骨骼的发现，通过协助研究人员进行最先进的肌肉骨骼评估生物测量。 ICCCR下的这些新的创新计划将联系我们的肌肉骨骼印第安纳州肌肉骨骼研究中心的研究人员，以识别新颖的现实资源诊断和治疗肌肉骨骼疾病的靶标。我们将挑战传统方法替补工作的卧床研究重点是患者表型进行板凳和返回研究。这会改善对具有常见疾病的许多肌肉骨骼疾病的定义和诊断发病机理和临床表现，通过将正确的治疗重点放在促进个性化医学每个患者。