Biostatistics Core

生物统计学核心

基本信息

批准号：
10247036
负责人：
PETER F THALL
金额：
$ 9.25万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-22 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10247036
关键词：
Administrator Authorization documentation Back Biometry Biostatistics Core Cancer Center Cell Therapy Child Client Clinical Trials Collaborations Communication Conduct Clinical Trials Consultations Data Data Analyses Data Set Database Management Systems Databases Development Devices Directories Doctor of Philosophy Dose ELF3 gene Ensure Environment Experimental Designs Fire - disasters Futility Grant Health system Home Housing Human Resources Information Systems Infrastructure Institution Internet Jordan Linux Manuscripts Medicine Memory Methods Modeling Monitor Online Systems Operating System Oranges Principal Investigator Protocols documentation Recovery Reporting Research Research Design Research Personnel Research Project Grants Resources Running Safety Secure Site Statistical Methods Statistical Models System The Sun Umbilical Cord Blood Universities University of Texas M D Anderson Cancer Center Washington base cloud storage cluster computing college computerized data processing data exchange data management design digital imaging encryption experience image processing meetings member multicore processor next generation sequencing novel parallel computer preclinical study software development terabyte virtual web app web services web site

项目摘要

PROJECT SUMMARY –CORE B The Biostatistics Core (Core B) will provide comprehensive, centralized biostatistical support for all four research projects. This support will integrate the biostatistical activities at the University of Texas MD Anderson Cancer Center (MDACC), Harvard University, and Children's National Health System (CNHS) at The George Washington University. These activities will include design of pre-clinical studies and clinical trials, data analysis, and data management. Dr. Peter Thall, PhD, who has collaborated with Drs. Shpall, Rezvani, Bollard, and Molldrem for many years on several different protocols and grants, will serve as Director of the Biostatistics Core. The Core personnel, Dr. Thall and Roland Bassett, MS, are highly experienced biostatisticians in the Department of Biostatistics of the MDACC. Dr. Thall, will coordinate the biostatistical support. Conduct of clinical trials will utilize the Biostatistics Department's Clinical Trial Conduct website. The specific aims of Core B are to (1) coordinate and manage biostatistical activities and ensure that investigators have ready access to biostatistical consultation, including experimental design, statistical modeling, data analysis, scientific interpretation, and reporting, (2) provide statistical design, modeling, and data analysis for pre-clinical studies, (3) provide statistical design and infrastructure for conduct of clinical trials, including sequentially adaptive futility/safety monitoring and dose-finding, and (4) provide support for data management in collaboration with the Administrative Core. If needed, the Core will draw on other resources and personnel in the Biostatistics Department at MDACC.

项目摘要 - 核心B 生物统计学核心（核心B）将为所有四个研究项目。这种支持将整合大学的生物统计活动德克萨斯州安德森癌症中心（MDACC），哈佛大学和儿童国家乔治华盛顿大学的卫生系统（CNHS）。这些活动将包括临床前研究和临床试验，数据分析和数据管理的设计。彼得博士曾与Drs合作的Thal，博士。 Shpall，Rezvani，Bollard和Molldrem为许多人在几种不同的方案和赠款上，将担任生物统计学核心主任。核心人员Thal博士和MS的Roland Bassett是经验丰富的生物统计学家在MDACC生物统计学系中。 Thal博士将协调生物统计支持。临床试验的行为将利用生物统计局的临床试验行为网站。核心B的具体目的是（1）协调和管理生物统计活动并确保调查人员可以随时获得生物统计咨询，包括实验设计，统计建模，数据分析，科学解释和报告，（2）为临床前研究提供统计设计，建模和数据分析，（3）提供用于进行临床试验的统计设计和基础设施，包括顺序适应性徒劳/安全监控和剂量调查，（4）为数据管理提供支持与行政核心的合作。如果需要，核心将利用其他资源，并 MDACC生物统计局的人员。