Tumor Biology and Microenvironment Program

肿瘤生物学与微环境项目

基本信息

批准号：
10245191
负责人：
MICHAEL M. SHEN
金额：
$ 9.89万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-04 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10245191
关键词：
3-Dimensional Address Advocacy African American Applications Grants Area Back Biology Biomedical Engineering Cancer Biology Cancer Center Support Grant Catchment Area Cell Communication Cell Lineage Cell physiology Cells Cellular Structures Clinic Clinical Clinical Data Clinical Research Clinical Trials Collaborations Development Digestive System Disorders Doctor of Philosophy Elements Epithelial Epithelial Cells Faculty Faculty Recruitment Fellowship Fostering Funding Future Genetic Genitourinary system Goals Grant Growth Human Immune Immunotherapeutic agent Immunotherapy Inflammation Infrastructure Interdisciplinary Study International Investigation Journals K-Series Research Career Programs Laboratories Laboratory Finding Lead Leadership Liver diseases Malignant Neoplasms Malignant neoplasm of pancreas Malignant neoplasm of prostate Medicine Mentors Mentorship Modeling Molecular Names Neurons Oncology Organoids Pathway interactions Patients Peer Review Phase I Clinical Trials Population Process Publications Regulatory T-Lymphocyte Research Research Personnel Resistance Resistance development Resource Sharing Scientist Signal Pathway Strategic Planning Stromal Cells Suppressor-Effector T-Lymphocytes Systems Biology Therapeutic Intervention Time Tissues Training Translating Translations Tumor Biology Underrepresented Minority Urology Vision anticancer research cancer cell cancer immunotherapy cancer stem cell career cell type cellular targeting clinical application clinical development cohesion immune checkpoint immunoregulation improved innovation insight meetings member men neoplasm immunotherapy neoplastic cell nerve supply novel novel therapeutics pre-clinical precision oncology preclinical study professor progenitor programs recruit self-renewal stem stem cell niche stem cells stemness targeted treatment transdifferentiation translational scientist translational study triple-negative invasive breast carcinoma tumor tumor growth tumor immunology tumor microenvironment

项目摘要

TUMOR BIOLOGY AND MICROENVIRONMENT PROGRAM: SUMMARY The Tumor Biology and Microenvironment (TBM) Program investigates cell-autonomous processes that underlie signaling pathways and cancer stemness as well as tumor cell-extrinsic mechanisms by which stromal niche factors and immune components modulate malignancy. Members pursue studies of novel immunotherapies and other stromal targeted therapeutics (e.g. neuronal cells), and incorporate new findings and innovative approaches such as 3D organoid cultures for translation to pre-clinical applications and development of early-stage clinical trials. The TBM program is led by Michael Shen, PhD, Timothy Wang, MD, and Charles Drake, MD, PhD who have complementary scientific expertise. They direct a program with 49 members who have been collectively responsible for $16.4M of cancer-focused peer-reviewed funding in 2019, as well as 800 publications, of which 251 publications in journals with an impact factor >10 in the current funding period. During the project period, there were 486 accruals to clinical trials, of which 235 were investigator-initiated, and 139 corresponded to underrepresented minority patients. The TBM Program pursues three interrelated Specific Aims: (1) Investigation of tissue stem/progenitor cells and cancer cell stemness to identify molecular mechanisms that drive tumor malignancy and plasticity, and to identify strategies to target these processes; (2) Analysis of the tumor microenvironment to understand how stromal- epithelial cell interactions and components of the stem cell niche can modulate tumor growth; and (3) Investigation of tumor immunology and immunotherapy to elucidate the interaction of immune cells with cancer stem cells and the mechanisms that underlie the resistance of tumors to immunotherapy. In particular, the TBM Program addresses research relevant for the catchment area by focusing on prostate cancer in African-American men, as well as studies of triple-negative breast and pancreatic cancers. The TBM Program fosters the growth of Members through meetings and retreats, development funds, support of multi-investigator grant proposals, support through Shared Resources, strategic faculty recruitments, and interactions with the other HICCC Programs. The TBM Program also provides leadership in cancer research career enhancement through mentorship of early-stage researchers through training grants, fellowships and career development awards. Future goals of the TBM program include support for strategic recruitments of senior and junior faculty (areas of therapies that target the interactions of cancer stem cells and the tumor microenvironment), increased clinical trials in the area of immunotherapy including overcoming nodes of resistance, and development of inter- programmatic platforms for precision oncology.

肿瘤生物学和微环境项目：摘要肿瘤生物学和微环境 (TBM) 计划研究细胞自主过程是信号通路和癌症干性以及肿瘤细胞外在机制的基础生态位因子和免疫成分调节恶性肿瘤。成员从事小说研究免疫疗法和其他基质靶向疗法（例如神经元细胞），并纳入新的发现和创新方法，例如用于转化为临床前应用和开发的 3D 类器官培养的早期临床试验。 TBM 项目由 Michael Shen 博士、Timothy Wang 医学博士和 Charles 领导 Drake，医学博士，哲学博士，拥有互补的科学专业知识。他们指导了一个由 49 名成员组成的项目 2019 年，共同负责 1640 万美元的癌症同行评审资金，以及 800 出版物，其中在当前资助期间影响因子>10的期刊上发表了251篇出版物。期间项目期间，共有 486 项临床试验应计项目，其中 235 项由研究者发起，139 项由研究者发起对应于代表性不足的少数族裔患者。 TBM 计划追求三个相互关联的具体目标：(1) 组织干/祖细胞的研究和癌细胞干性，以确定驱动肿瘤恶性和可塑性的分子机制，并确定针对这些流程的策略； (2) 分析肿瘤微环境以了解基质如何上皮细胞相互作用和干细胞生态位的成分可以调节肿瘤生长；和（3）研究肿瘤免疫学和免疫治疗，以阐明免疫细胞与癌症的相互作用干细胞和肿瘤对免疫治疗产生抵抗力的机制。特别是TBM 该计划通过关注非裔美国人的前列腺癌来开展与该地区相关的研究男性，以及三阴性乳腺癌和胰腺癌的研究。 TBM 计划促进增长通过会议和务虚会、发展基金、多研究者资助提案的支持，通过共享资源、战略性教师招聘以及与其他 HICCC 的互动提供支持节目。 TBM 计划还通过以下方式在癌症研究职业发展方面发挥领导作用：通过培训补助金、奖学金和职业发展奖对早期研究人员进行指导。 TBM 计划的未来目标包括支持高级和初级教师的战略招聘（以下领域）：针对癌症干细胞和肿瘤微环境相互作用的疗法），增加了临床免疫疗法领域的试验，包括克服耐药节点和开发间质疗法精准肿瘤学的程序化平台。