Genetic Approaches to Development and Disease

发育和疾病的遗传学方法

• 批准号: 10206946
• 负责人: MICHAEL M. SHEN
• 金额: $ 39.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10206946
• 关键词: Development; Disease; genetic approach

PROJECT SUMMARY This proposal describes a new PhD training program, Genetic Approaches to Development and Disease (GADD) at Columbia University Irving Medical Center (CUIMC), which trains young scientists in the use of modern genetics to address major challenges in biomedical research. There is an essential need for specific training of PhD students in genetic approaches due to the prevalent use of genetically tractable model organisms, the evolution of modern genetic techniques, and the complexities of genomic analyses in mammalian systems, including human patients. The GADD program has been designed to meet this need. Students in the GADD program receive advanced training in genetic analyses using model organisms, current genetic and genomic techniques, biostatistics, history of genetics, and the ethics of modern genetics. The GADD training program functions as a highly selective training program that draws together dynamic, well- funded faculty and outstanding students from departments and research centers across Columbia University based on their thematic fit, rigorous research, and mentoring abilities. The training program features a rigorous curriculum that emphasizes critical thought and development of writing and presentation skills, together with regular feedback and individualized mentoring of each student. Trainees in our faculty training labs who have graduated in the last five years show excellent training outcomes, with reasonable time-to-degree (just under 6 years), a high percentage of funding awards (26%) and first-author publications (97%), and successful research, educational, or research-related careers (94%). A major goal of the GADD program is diversification of the biomedical workforce through effective recruitment, retention, and support: URM students represent 16% of current students. The proposed GADD training grant will provide academic, social, and career development support to all of its students through structured training activities and close monitoring of student progress and will replace the previous Genetics and Development (G&D) training grant. Overall, the GADD program represents a premier genetics-focused graduate program that has a long track-record of success in training leaders in biomedical research and a modern training plan to continue its contributions in the future.

项目概要 该提案描述了一个新的博士培训计划，“发育和疾病的遗传方法” 哥伦比亚大学欧文医学中心 (CUIMC) 的 (GADD)，该中心培训年轻科学家如何使用 现代遗传学解决生物医学研究的重大挑战。迫切需要特定的 由于普遍使用遗传易处理的模型生物，对博士生进行遗传方法培训， 现代遗传技术的演变以及哺乳动物系统中基因组分析的复杂性， 包括人类患者。 GADD 计划就是为了满足这一需求而设计的。 GADD 项目的学生接受使用模型生物进行遗传分析的高级培训， 当前的遗传学和基因组技术、生物统计学、遗传学史以及现代遗传学伦理学。 GADD 培训计划作为一个高度选择性的培训计划，汇集了充满活力、良好的培训计划。 资助哥伦比亚大学各院系和研究中心的教师和优秀学生 基于他们的主题契合、严谨的研究和指导能力。培训计划具有严格的特点 强调批判性思维以及写作和演讲技巧发展的课程，以及 对每个学生进行定期反馈和个性化指导。我们的教师培训实验室的学员 过去五年的毕业生表现出出色的培训成果，获得学位的时间合理（略低于 6 年）、高比例的资助奖励（26%）和第一作者出版物（97%）以及成功的研究， 教育或研究相关职业（94%）。 GADD 计划的一个主要目标是多元化 通过有效的招聘、保留和支持来培养生物医学劳动力：URM 学生占 16% 现在的学生。拟议的 GADD 培训补助金将提供学术、社会和职业发展 通过结构化的培训活动和密切监控学生的进步和情况，为所有学生提供支持 将取代之前的遗传与发育 (G&D) 培训补助金。总体而言，GADD 计划 代表了一个以遗传学为重点的一流研究生项目，该项目在培训方面拥有悠久的成功记录 生物医学研究领域的领导者和现代培训计划将在未来继续做出贡献。