A Longitudinal Study of Gender Nonconformity in Prepubescent Children

青春期前儿童性别不一致的纵向研究

• 批准号: 10132366
• 负责人: Diane Chen
• 金额: $ 65.5万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-21 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10132366
• 关键词: Address; Adolescence; Adolescent; Agreement; Area; Attention; Behavior; Behavioral; Birth; Boston; California; Caregivers; Caring; Characteristics; Chicago; Child; Childhood; Classification; Clinic; Clinical; Clinical Management; Cognition; Collaborations; Collection; Companions; Consensus; Data; Data Reporting; Development; Diagnosis; Distress; Enrollment; Family; First Name; Funding; Gender; Gender Identity; Gender Role; Goals; Grant; Health; Healthcare; Individual; Institute of Medicine (U.S.); Intervention; Investigation; Knowledge; Lesbian Gay Bisexual Transgender; Life Cycle Stages; Longitudinal Studies; Longitudinal cohort; Longitudinal cohort study; Longitudinal prospective study; Los Angeles; Measures; Mental Health; National Institute of Child Health and Human Development; Outcome; Parents; Participant; Pattern; Pediatric Hospitals; Prognosis; Reporter; Reporting; Research; Research Support; Resources; Risk; Role; Sampling; San Francisco; Site; Subgroup; Symptoms; Time; United States; United States National Institutes of Health; Universities; University Hospitals; Work; Youth; base; behavioral health; clinical care; clinical practice; cohort; early childhood; emerging adult; experience; externalizing behavior; gender dysphoria; gender expression; gender nonconforming; gender transition; improved; medical schools; person centered; population based; prepuberty; programs; psychosocial; recruit; resilience; sex; social; transgender

PROJECT SUMMARY/ABSTRACT The purpose of this proposed study is to establish a national cohort of prepubertal transgender/gender- nonconforming (TGNC) children (and their parents), and longitudinally observe this cohort to expand the body of empirical knowledge pertaining to gender development and cognition in TGNC children, their mental health symptomology and functioning over time, and how family-initiated social gender transition may predict or alleviate mental health symptoms and/or diagnoses. Participants will be recruited and enrolled either at one of four Gender Centers dedicated to their care (Children's Hospital Los Angeles/University of Southern California; Lurie Children's Hospital of Chicago/Northwestern University; Boston Children's Hospital/Harvard Medical School; Benioff Children's Hospital/University of California San Francisco), and followed over a 2-year observational period, with clinical and behavioral data collected from prepubertal TGNC children and their parents at 6-month intervals. The proposed study will use state-of-the-art measures and utilize statistical advances in person-centered analytical approaches (i.e., latent class analysis and latent transition analysis) to address inconsistencies in prior studies, which have focused primarily on variable-centered approaches. The proposed study leverages the resources of the only NIH-funded network of US-based pediatric gender centers (Grant #R01HD082554), expanding on this current collaboration (studying TGNC adolescents) to include a younger and understudied cohort of prepubertal TGNC children. Together, these sites share a long-term goal and anticipate expanding investigation into a program of research that examines the experiences and needs of TGNC youth from early childhood through early adulthood. This proposal sets up an ideal framework to continue collecting longitudinal data from the cohort recruited for this initial work, as well as understand the additional complexities of this population based on the cohorts recruited in the companion study of peripubertal and pubertal TGNC adolescents (Grant #R01-HD082554).

项目摘要/摘要 这项拟议的研究的目的是建立一个全国性的青春期前变性者/性别队列 不合格（TGNC）儿童（及其父母），并纵向观察这个队列以扩大身体 与TGNC儿童的性别发展和认知有关的经验知识，他们的心理健康 随着时间的流逝，症状和功能，以及家庭引发的社会性别转变如何预测或 减轻心理健康症状和/或诊断。参与者将被招募和入学 四个致力于护理的性别中心（洛杉矶儿童医院/南加州大学； 芝加哥/西北大学Lurie儿童医院；波士顿儿童医院/哈佛医疗 学校;贝尼奥夫儿童医院/加利福尼亚大学旧金山大学），紧随其后2年 观察期，从青春期前TGNC儿童及其收集的临床和行为数据及 父母以6个月的间隔。拟议的研究将使用最新的措施并利用统计 以人为本的分析方法（即潜在类别分析和潜在过渡分析）的进步 解决了先前研究中的不一致之处，这些研究主要集中在以可变为中心的方法上。这 拟议的研究利用了美国NIH资助的基于美国儿科中心的唯一资源的资源 （授予＃R01HD082554），扩展了此当前合作（研究TGNC青少年），以包括一个 年轻且研究研究的前TGNC儿童。这些网站共同共享一个长期目标 并预计将调查扩大到研究计划的研究计划，该计划研究的经验和需求 TGNC从小到成年的青年。该提案为 继续从招募的这项初始工作的同类人群中收集纵向数据，并了解 基于peripubertal的同伴研究中招募的同类人群的其他复杂性 和青春期的TGNC青少年（授予＃R01-HD082554）。