Linking temporal patterns of modifiable behaviors to weight loss outcomes

将可改变行为的时间模式与减肥结果联系起来

• 批准号: 10093124
• 负责人: Seth A Creasy
• 金额: $ 16.42万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10093124
• 关键词: Address; Adherence; Adult; Award; Beds; Behavior; Behavioral; Body Weight decreased; Calories; Cardiovascular Diseases; Chronic Disease; Clinical; Colorado; Consumption; Data; Development; Diet; Doctor of Philosophy; Eating; Eating Behavior; Effectiveness; Energy Intake; Enrollment; Epidemiology; Funding; Future; Goals; Health behavior; Individual; Intake; Intervention; Investigation; K-Series Research Career Programs; Laboratory Study; Lead; Life Style; Link; Maintenance; Malignant Neoplasms; Medical; Mentors; Methodology; Methods; Mission; National Heart, Lung, and Blood Institute; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Participant; Pattern; Physical activity; Public Health; Recommendation; Regulation; Reporting; Research; Research Personnel; Scientist; Series; Sleep; Sum; Techniques; Testing; Time; Training; Universities; adequate sleep; adult obesity; behavior influence; cardiovascular disorder risk; cardiovascular risk factor; career; catalyst; doubly-labeled water; improved; indexing; innovation; lifestyle intervention; modifiable behavior; mortality; multidisciplinary; novel; novel therapeutic intervention; obesity prevention; prevent; sleep behavior; sleep pattern; sleep quality; theories; total energy expenditure; weight loss intervention; weight maintenance

PROJECT SUMMARY & ABSTRACT This K01 Career Development Award addresses the significance of three key modifiable behaviors (physical activity, energy intake, and sleep) for weight loss and weight loss maintenance. Previous investigations have identified that the absolute amounts of physical activity (200-300 min/wk) and energy intake (~1800 kcal/day) are associated with weight loss and weight loss maintenance. In addition to physical activity and energy intake, epidemiological and controlled laboratory studies suggest that sleep is important for bodyweight regulation; however, the importance of sleep during a behavioral weight loss intervention has not yet been evaluated. This study will be one of the first studies to evaluate if indices of sleep are associated with enhanced adherence to physical activity and energy intake prescriptions during a weight loss intervention and greater weight loss. Findings from this study may lead to more comprehensive behavioral weight loss therapies focusing on sleep behavior as well as physical activity and eating behaviors. In addition to the absolute amounts of physical activity, energy intake, and sleep, emerging evidence suggests that temporal patterns (timing across the 24h day and consistency day-to-day) of these behaviors influence weight loss outcomes. The global hypothesis is of this application is that earlier timing of these behaviors (e.g. morning physical activity, eating more calories earlier in the day, earlier bed/ early rise times) and consistency (day-to-day and weekday-to-weekend) will be associated with greater weight loss, better adherence to the diet and physical activity prescriptions during a behavioral weight loss intervention, and weight loss maintenance. Identifying temporal patterns of these behaviors that are associated with enhanced adherence and greater weight loss will aid in the development of novel, translatable, and effective behavioral strategies for long-term weight loss. The proposed research plan will advance the career of the applicant, Seth A. Creasy, PhD facilitating his transition to independent investigator status over the five years of K01 support. A team of highly productive, multidisciplinary scientists (Drs. Edward Melanson, Victoria Catenacci, Nichole Carlson, Celine Vetter, Valerie Myers) will collectively serve as mentors to Dr. Creasy during the proposed research at the University of Colorado – Anschutz Medical Campus. This team of mentors has the expertise to train Dr. Creasy in physical activity assessment methods, doubly labeled water theory and methodology, assessing energy intake, novel metrics for quantifying times-series data, and developing/conducting large, clinical weight loss interventions. In sum, the proposed training and expert mentoring team will provide Dr. Creasy with the skillset and preliminary data necessary to compete for R01 funding, and this award will serve as a catalyst making Dr. Creasy a leader in the field of lifestyle interventions for treating and preventing obesity.

项目摘要和摘要 该K01职业发展奖旨在解决三种主要可修改行为的重要性（物理 活动，能量摄入和睡眠），以减轻体重和体重减轻。先前的调查已有 确定体育锻炼的绝对量（200-300分钟/周）和能量摄入量（约1800 kcal/day） 与体重减轻和减肥维持有关。除了体育锻炼和能量摄入量， 流行病学和对照实验室研究表明，睡眠对于体重调节很重要。 但是，尚未评估行为减肥干预过程中睡眠的重要性。这 研究将是评估睡眠指标是否与依从性增强有关的最早研究之一 体育活动和能量摄入处方在减肥干预期间和体重减轻更大。 这项研究的发现可能导致更全面的行为减肥疗法，重点是睡眠 行为以及体育锻炼和饮食行为。除了绝对的体育锻炼量之外， 能量摄入和睡眠，新兴的证据表明临时模式（在24小时内的时间和时间 这些行为的日常一致性会影响减肥结果。全球假设就是这样 应用是这些行为的较早时机（例如，早晨的体育锻炼，早些时 一天，较早的床/早升时间）和一致性（日常和工作日至周末）将相关联 随着体重减轻的更大，行为期间更好地遵守饮食和体育锻炼处方 减肥干预和减肥维持。确定这些行为的临时模式 与增强的依从性和更大的体重减轻相关，将有助于新颖，可翻译， 以及长期体重减轻的有效行为策略。拟议的研究计划将推进职业 申请人的塞思·A·克雷西（Seth A. Creasy K01支持年。一个高产，多学科科学家的团队（维多利亚州的爱德华·梅兰森博士 Catenacci，Nichole Carlson，Celine Vetter，Valerie Myers）将共同担任Creasy博士的导师 科罗拉多大学Anschutz Medical Campus的拟议研究。这个导师团队有 培训Creasy博士在体育锻炼评估方法，双重标记水理论和 方法论，评估能量摄入，量化时间序列数据的新型指标以及 开发/进行大型临床减肥干预措施。总而言之，拟议的培训和专家 指导团队将为Creasy博士提供竞争R01所需的技能和初步数据 资金，该奖项将成为催化剂，使Creasy博士成为生活方式干预领域的领导者 用于治疗和预防肥胖症。