Physical activity intervention co-created and pilot tested with African American Colorectal Cancer Survivors

与非裔美国结直肠癌幸存者共同创建和试点测试身体活动干预措施

基本信息

批准号：
10095200
负责人：
Rachel Hirschey
金额：
$ 15.92万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-03 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10095200
关键词：
Accelerometer Address Adoption Advanced Development African American Award Biological Markers Cancer Survivor Cause of Death Characteristics Clinic Clinical Colorectal Cancer Control Groups Data Development Diagnosis Discrimination Environment Ethnic group Fatigue Feedback Foundations Functional disorder Future Goals Habits Health Health Promotion Healthcare Systems Individual Inflammation Intervention Interview Intestines Knowledge Low income Malignant Neoplasms Measures Mental Depression Meta-Analysis Neighborhoods Oncology Outcome Outcome Measure Pain Participant Pathway interactions Physical activity Pilot Projects Population Poverty Predictive Factor Provider Psychological reinforcement Publishing Quality of life Race Randomized Reach, Effectiveness, Adoption, Implementation, and Maintenance Recommendation Reporting Research Research Personnel Resources Sampling Scientist Self Efficacy Stress Surveys Survivors Symptoms Tablets Technology Testing Text Messaging Time Training Treatment Protocols Treatment Side Effects Variant Walking cancer care cancer health disparity cancer therapy cancer type care systems chemotherapy colorectal cancer treatment cost effectiveness testing efficacy outcomes efficacy testing exercise intervention expectation experience fitbit group intervention high risk implementation design implementation intervention improved interest malignant breast neoplasm mortality multi-component intervention novel strategies pain symptom post intervention programs psychosocial racial and ethnic recruit response side effect skills social culture standard care therapy design vigorous intensity

项目摘要

Project Summary/Abstract The long-term objective of this research is to improve physical activity among populations experiencing cancer disparities. The goal of this training award is to: (1) deliver a multicomponent, culturally-targeted, technology- delivered, scalable intervention to increase physical activity among African American colorectal cancer survivors; while advancing the development of a new investigator, with a program of research focused on increasing physical activity and decreasing cancer disparities. Specific aims are to: (1) co-create, with AA CRC survivors who engaged in physical activity throughout cancer treatment, culturally targeted narrative videos to increase physical activity knowledge, self-efficacy, outcome expectations, habits and enjoyment; (2) pilot test the intervention to assess reach, effectiveness, adoption, implementation, and maintenance and; and (3) measure outcomes at baseline, 3- and 9-months post baseline. Outcomes include: psychosocial constructs related to physical activity engagement (knowledge, self-efficacy, outcome expectations, enjoyment, habits); physical activity (average daily steps, weekly minutes of moderate-vigorous intensity activity); symptoms (pain, fatigue, depression, bowel dysfunction); and inflammation biomarkers that may explain the pathways through which physical activity impacts cancer outcomes. First, a qualitative exploratory approach will be used to interview 20 African American colorectal cancer survivors. Together with a subset of interested participants a multi-component intervention to increase physical activity among African American colorectal cancer survivors will be created. Next, an additional 72 participants will be recruited to conduct a pilot two-group, randomized repeated measures study to assess Reach, Effectiveness, Adoption, Implementation and Maintenance (RE- AIM) of the intervention. Feasibility of collecting survey and biomarker data at baseline, 3 and 9 months later will be assessed. These timepoints will facilitate exploration of changes pre- and post-intervention, and to determine if effects are maintained 6 months after completing the intervention and chemotherapy. Time since last chemotherapy will be controlled for in all analyses to account for variations in treatment schedules.

项目概要/摘要这项研究的长期目标是改善癌症患者的身体活动差异。该培训奖的目标是：(1) 提供多组成部分、针对文化的技术- 提供可扩展的干预措施，以增加非裔美国人结直肠癌患者的体力活动幸存者；同时推进新研究者的发展，研究计划的重点是增加体力活动并减少癌症差异。具体目标是： (1) 与 AA CRC 共同创建在整个癌症治疗过程中进行身体活动的幸存者，针对文化的叙事视频增加身体活动知识、自我效能、结果预期、习惯和享受； (2)中试评估影响范围、有效性、采用、实施和维护的干预措施；和（3）衡量基线、基线后 3 个月和 9 个月的结果。结果包括：心理社会结构与身体活动参与相关（知识、自我效能、结果期望、享受、习惯）；身体活动（平均每日步数、每周中等强度活动的分钟数）；症状（疼痛、疲劳、抑郁、肠功能障碍）；和炎症生物标志物可以解释通过的途径哪些体力活动会影响癌症的结果。首先，将采用定性探索方法采访 20 名非裔美国结直肠癌幸存者。与一部分感兴趣的参与者一起多成分干预以增加非裔美国结直肠癌幸存者的体力活动将被创建。接下来，将另外招募 72 名参与者进行试点，分为两组、随机重复措施研究，以评估影响范围、有效性、采用、实施和维护（RE- 干预的目的）。在基线、3 个月和 9 个月后收集调查和生物标志物数据的可行性将被评估。这些时间点将有助于探索干预前后的变化，并确定完成干预和化疗后 6 个月是否能维持效果。时间自在所有分析中都将控制最后一次化疗，以解释治疗方案的变化。