DEFINING STRATEGIES FOR IMPROVING ENDOTHELIAL/FIBRINOLYTIC DYFUNCTION IN OBESITY

制定改善肥胖症内皮/纤溶功能障碍的策略

• 批准号: 7731488
• 负责人: Douglas E Vaughan
• 金额: $ 0.05万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731488
• 关键词: Alteplase; Computer Retrieval of Information on Scientific Projects Database; Development; Endocrine; Funding; Grant; Institution; Obesity; Plasminogen Activator Inhibitor 1; Production; Research; Research Personnel; Resources; Source; System; Testing; Thrombosis; United States National Institutes of Health; autocrine; improved; paracrine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central hypothesis is that vacular PAI-1 excess promotes the development of intravascular thrombosis. We will test that secreted factors from adiocytes have autocrine, paracrine, and endocrine effects that have deleterious effect on the fibrinolytic system, either by enhancing PAI-1 production or impairing endothelial t-PA release.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 中心假设是，真空PAI-1过量促进了血管内血栓形成的发展。我们将测试通过增强PAI-1产生或损害内皮T-PA释放，对腺细胞的分泌因子具有自分泌，旁分泌和内分泌作用，对纤维蛋白水解系统具有有害作用。