DEFINING STRATEGIES FOR IMPROVING ENDOTHELIAL/FIBRINOLYTIC DYFUNCTION IN OBESITY

制定改善肥胖症内皮/纤溶功能障碍的策略

• 批准号: 7731488
• 负责人: Douglas E Vaughan
• 金额: $ 0.05万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7731488
• 关键词: Alteplase; Computer Retrieval of Information on Scientific Projects Database; Development; Endocrine; Funding; Grant; Institution; Obesity; Plasminogen Activator Inhibitor 1; Production; Research; Research Personnel; Resources; Source; System; Testing; Thrombosis; United States National Institutes of Health; autocrine; improved; paracrine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central hypothesis is that vacular PAI-1 excess promotes the development of intravascular thrombosis. We will test that secreted factors from adiocytes have autocrine, paracrine, and endocrine effects that have deleterious effect on the fibrinolytic system, either by enhancing PAI-1 production or impairing endothelial t-PA release.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 中心假设是血管 PAI-1 过量会促进血管内血栓形成。我们将测试脂肪细胞分泌的因子具有自分泌、旁分泌和内分泌作用，这些作用通过增强 PAI-1 的产生或损害内皮 t-PA 的释放，对纤溶系统产生有害影响。