LUNG DISEASE IN CHILDREN WITH MILD CF LUNG DISEASE

患有轻度 CF 肺病的儿童的肺部疾病

• 批准号: 7717907
• 负责人: Terry E. Robinson
• 金额: $ 0.41万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717907
• 关键词: Age; Air; Bronchiectasis; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Elastases; Funding; Future; Grant; IL8 gene; Image; Institution; Intervention Trial; Lung; Lung diseases; Measurement; Mucous body substance; Natural History; Outcome Measure; Pancreatic Elastase; Pharmaceutical Preparations; Research; Research Personnel; Resources; Score; Source; Specimen; Spirometry; Sputum; Subgroup; Thick; United States National Institutes of Health; Visual; X-Ray Computed Tomography; airway inflammation; base; children with cystic fibrosis; design; prospective; pulmonary function; trial comparing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective, two year natural history study is designed to study changes in spirometry-controlled volumetric lung CT imaging and quantitative CT measurements of air trapping and bronchial airway measurements together with CF CT scoring and traditional pulmonary function measurements, and clinical scores in CF children with initially mild lung disease. In addition, in a subgroup of mild CF children ages 10-18 years who can effectively expectorate and provide sputum specimens, sputum IL-8 and sputum elastase will also be evaluated to assess the effect of airway inflammation on CT measurements and other clinical parameters during this two year natural history study. It is predicted that the spirometry-controlled lung CT imaging & quantitative CT measurements will detect initial and progressive changes in lung disease in CF children with mild lung disease over the two year study period. These initial manifestations of lung disease will be regional air trapping and increased bronchial wall thickness, followed by bronchiectasis and larger airway mucus plugging. These changes should provide more viable outcome measures for future multi-center drug intervention trials compared to traditional CF CT scoring which is based on visual assessment of the CT scans.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项为期两年的前瞻性自然史研究旨在研究肺活量测定控制的容积肺 CT 成像、空气滞留和支气管气道测量的定量 CT 测量的变化，以及 CF CT 评分和传统的肺功能测量，以及患有以下疾病的 CF 儿童的临床评分：最初是轻度肺部疾病。此外，在能够有效咳痰并提供痰标本的10-18岁轻度CF儿童亚组中，还将评估痰IL-8和痰弹性蛋白酶，以评估气道炎症对CT测量和其他临床参数的影响。这两年的自然历史研究。 据预测，肺量测定控制的肺部 CT 成像和定量 CT 测量将在两年的研究期间检测患有轻度肺部疾病的 CF 儿童肺部疾病的初始和进展变化。 肺部疾病的最初表现是局部空气滞留和支气管壁厚度增加，然后是支气管扩张和较大的气道粘液堵塞。与基于 CT 扫描视觉评估的传统 CF CT 评分相比，这些变化将为未来的多中心药物干预试验提供更可行的结果衡量标准。