AN OBSERVATIONAL STUDY OF FOOD ALLERGY

食物过敏的观察性研究

• 批准号: 7718173
• 负责人: SCOTT H SICHERER
• 金额: $ 1.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718173
• 关键词: Accounting; Allergens; Allergic; Allergy to eggs; Allergy to peanuts; Antibiotics; Antibodies; Antigens; Atopic Dermatitis; Biological Markers; CD4 Positive T Lymphocytes; Candidate Disease Gene; Child; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Diet; Dust; Endotoxins; Enrollment; Environment; Environmental Exposure; Epitopes; Exposure to; Food Hypersensitivity; Funding; Genes; Genetic; Genetic Polymorphism; Grant; Homologous Protein; Human Milk; Hypersensitivity; IgE; Immune; Immunologics; Infant; Institution; Intervention; Ligands; Milk; Milk Hypersensitivity; National Institute of Allergy and Infectious Disease; Numbers; Observational Study; Oral; Outcome; Ownership; Peanuts - dietary; Peripheral; Persons; Phenotype; Proteins; Recruitment Activity; Research; Research Personnel; Resolution; Resources; Risk; Severities; Siblings; Site; Source; T-Cell Development; T-Lymphocyte; Testing; Time; Toll-like receptors; United States National Institutes of Health; cohort; developmental immunology; egg; experience; prevent; soy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is only a limited understanding of the mechanisms involved in the developmental course of food allergies. To effectively prevent or reverse the progression of food allergy, immune interventions will be needed. Furthermore, it is likely that successful strategies will need to be directed to those persons at identifiable risk (e.g., who have biomarkers associated with development of peanut allergy). This NIH (NIAID) sponsored multi-center (5 sites) observational study will investigate the developmental immunology of peanut, egg and milk allergy in a cohort of milk or egg allergic children who are at risk for peanut allergy. We will recruit 400 infants (approximately 80 at Mount Sinai) with milk or egg allergy and approximately 250 sibling controls (approximately 50 at Mount Sinai) for genetic and immunological studies. Enrolled infants will be evaluated over a 4.5 year period during which time we predict that approximately 20% will develop clinical peanut allergy and 25-50% will experience resolution of egg or milk allergy. We will perform directed immune testing (T cell studies, humoral studies), explore candidate genes that may influence food allergy (toll like receptor polymorphisms) and evaluate environmental exposures and diet that may influence outcomes. This strategy should enable us to delineate, compare and contrast biological markers and immunologic changes associated with the development of peanut allergy and loss of egg and milk allergy while simultaneously evaluating important clinical and environmental influences likely to account for the recent alarming rise in these allergies. Hypotheses to be tested include: The development and persistence of clinical peanut allergy (non-resolution of egg/milk allergy) is associated with: the development of an allergen-specific, Th2- skewed T cell phenotype; a decrease in the T regulatory phenotype of antigen-activated peripheral CD4+ T cells; development of an epitope-specific IgE antibody profile that is distinct from persons without clinical allergy; Toll-like receptor (TLR) Polymorphisms and related genes that impair responsiveness to TLR ligands; Early exposure to allergenic proteins (via breast milk or oral exposure) or homologous proteins (soy); less than strict avoidance of the causal proteins; Low exposure to TLR ligands in the environment (dust endotoxin, pet ownership, number of siblings, daycare, antibiotic use, etc); and the severity of atopic dermatitis.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 对食物过敏的发育过程中涉及的机制只有有限的理解。 为了有效防止或扭转食物过敏的进展，需要采取免疫干预措施。 此外，可能需要将成功的策略直接针对那些具有可识别风险的人（例如，具有与花生过敏的发展相关的生物标志物）。 这项NIH（NIAID）赞助的多中心（5个地点）观察性研究将调查在患有花生过敏风险的牛奶或鸡蛋过敏儿童中花生，鸡蛋和牛奶过敏的发育免疫学。 我们将通过牛奶或鸡蛋过敏招募400名婴儿（大约80名在西奈山），大约250个同胞对照（在西奈山约50个）进行遗传学和免疫学研究。 在4。5年期间，将评估入学的婴儿，在此期间，我们预测约有20％会产生临床花生过敏，而25-50％的婴儿将经历卵或牛奶过敏的分辨率。 我们将进行定向的免疫测试（T细胞研究，体液研究），探索可能影响食物过敏的候选基因（像受体多态性这样的收费），并评估可能影响结果的环境暴露和饮食。 该策略应该使我们能够描述，比较和对比生物学标记以及与花生过敏以及卵和牛奶过敏的损失相关的免疫学变化，同时评估重要的临床和环境影响，这可能会影响这些过敏反应的最新令人震惊。 要测试的假设包括： 临床花生过敏的发育和持久性（卵/牛奶过敏的非分辨率）与：特异性特异性Th2-偏斜的T细胞表型的发展；抗原激活的周围CD4+ T细胞的T调节表型减少；发育的表位特异性IgE抗体概况与没有临床过敏的人不同；损害对TLR配体反应性的收费样受体（TLR）多态性和相关基因；早期暴露于过敏蛋白（通过母乳或口服暴露）或同源蛋白（大豆）；不超过严格避免因果蛋白；环境中对TLR配体的暴露率低（灰尘内毒素，宠物所有权，兄弟姐妹数量，日托，抗生素使用等）；以及特应性皮炎的严重程度。