Promoting DEIA in Lung Disease Research Through a Mentored Training Experience at IUB-SPH

通过 IUB-SPH 的指导培训经验促进 DEIA 在肺部疾病研究中的应用

• 批准号: 10792180
• 负责人: Patricia Silveyra
• 金额: $ 39.62万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-10 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792180
• 关键词: Accounting; Administrative Supplement; Adverse effects; Affect; Agonist; Air; Allergens; Allergic inflammation; Androgen Receptor; Androgens; Animal Model; Anti-Inflammatory Agents; Asthma; Award; Biological; Cells; Cementation; Development; Diagnosis; Disparity; Elements; Environmental Exposure; Environmental Risk Factor; Epithelial Cells; Epithelium; Estradiol; Estrogen Receptors; Estrogens; Estrous Cycle; Exposure to; Female; Four Core Genotypes; Funding; Gender; Gene Expression; Gene Expression Profile; Genetic Transcription; Goals; Gonadal Hormones; Gonadal Steroid Hormones; Graduate Education; Growth Factor; Harvest; Health; Hormone Receptor; Hormones; Human; Immune; Immunology; Indiana; Individual; Individual Differences; Inflammation; Inflammatory; Inflammatory Response; Inhalation; Institution; Internships; Investigation; Knowledge; Laboratories; Leadership; Life; Liquid substance; Lung; Lung diseases; Mediating; Mentors; Mentorship; Mission; Modeling; Molecular; Morbidity - disease rate; National Heart, Lung, and Blood Institute; Outcome; Parents; Participant; Pathway Analysis; Patients; Persons; Phase; Physiological; Predisposition; Prevalence; Prevention; Process; Progesterone; Progesterone Receptors; Program Development; Puberty; Public Health; Public Health Schools; Pulmonary Inflammation; Pyroglyphidae; RNA; Reporting; Research; Research Priority; Research Project Grants; Research Training; Respiratory Disease; Risk; STEM field; STEM research; Science; Severities; Sex Chromosomes; Sex Differences; Signal Transduction; Stanolone; Stimulus; Students; System; Testing; Training; Training Programs; Training Technics; United States; Universities; Woman; Work; airway epithelium; antagonist; asthma exacerbation; asthmatic; asthmatic patient; bronchial epithelium; career; career awareness; career development; chemokine; cohort; cytokine; design; equity, diversity, and inclusion; experience; experimental study; female sex hormone; in vivo; inflammatory lung disease; leadership development; male; male sex hormones; men; middle age; mouse model; multiplex assay; novel; prevent; programs; protein biomarkers; protein expression; pulmonary function; pulmonary symptom; receptor; recruit; response; sex; specific biomarkers; summer research; technology platform; undergraduate student; virtual

PROJECT SUMMARY This Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) Mentorship proposal expands on the research goals of parent study and its associated diversity supplement, which aim to a) investigate the mechanisms by which gonadal sex hormones contribute to asthma development and progression, and b) discover basic biological differences underlying the influence of sex and gender in asthma presentation and outcomes. If funded, this supplement award will provide support for 10 undergraduate student trainees to help conduct this research and participate in a culturally relevant leadership development and research training program. The specific activities of this administrative supplement will support DEIA by supporting the career development of a cohort of students from traditionally underrepresented backgrounds in STEM fields, while expanding the research goals of the parent award. This will be accomplished by 1) building student awareness of career opportunities, 2) increasing student knowledge of the science research/discovery process, 3) cementing individual resolve, perseverance and confidence in students, and 4) exposing students to a variety of professionals from a multitude of backgrounds in public health to expand their options for career selection. Specifically, a cohort of 10 students from institutions across the United States, and from backgrounds underrepresented in STEM, will be recruited for an integrated leadership development and research training program at Indiana University Bloomington School of Public Health (IUB-SPH). The first phase of the program will focus on cohort-building activities that will be conducted virtually over 3-months, and include elements of career development training that will prepare them for a summer research experience. The second phase of the program will consist of an 8-week in-person summer research intensive experience at IUB-SPH, where students will participate in a) an intensive in-person individual leadership development program, b) a hands-on laboratory techniques training, c) the completion of an independent research project aimed to characterize sex differences in pro-inflammatory gene expression triggered by allergen exposure in primary human bronchial epithelial cells, as well as to detect novel sex- specific protein biomarkers for allergic inflammation in the lung epithelium using an immunology multiplex analysis technology platform. Similar to the parent award and its associated diversity supplement, this administrative supplement is well-aligned with the research priorities of NHLBI by investigating pathobiological mechanisms important to the onset and progression of lung diseases, identifying factors that account for individual differences in lung disease pathobiology, including sex differences and the influence of sex, and developing, diversifying, and sustaining a scientific workforce capable of accomplishing the institute’s mission.

项目摘要 这种行政补充，以表彰多样性，公平，包容性和可访问性的卓越 （DEIA）指导建议扩展了父母研究的研究目标及其相关的多样性 补充，目的是a）研究性腺性激素有助于哮喘的机制 发展和进展，b）发现性别影响和 性别在哮喘表现和结果中。如果资助，该补充奖项将为10个提供支持 本科生学员可以帮助进行这项研究并参与与文化相关的领导 发展与研究培训计划。这种行政补充的具体活动将 支持DEIA，通过支持传统上代表性不足的一群学生的职业发展来支持DEIA STEM领域的背景，同时扩大父母奖的研究目标。这将是 通过1）建立学生对职业机会的认识，2）增加学生对 科学研究/发现过程，3）巩固个人的决心，毅力和信心 学生，以及4）将学生暴露于来自公众众多背景的各种专业人员 健康以扩大其职业选择的选择。具体而言，来自机构的10名学生组成的队列 美国，从STEM中代表不足的背景中，将被招募作为综合的 印第安纳大学布卢明顿公立学校的领导力发展与研究培训计划 健康（IUB-SPH）。该计划的第一阶段将重点介绍将要进行的队列建设活动 几乎超过3个月，包括职业发展培训的要素，这些培训将为他们做好准备 夏季研究经验。该计划的第二阶段将包括一个为期8周的面对面的夏季 IUB-SPH的研究深入经验，学生将参加A）面对面的密集 个人领导力发展计划，b）实验实验室技术培训，c）完成 一个独立的研究项目，旨在表征促炎基因表达的性别差异 由过敏原暴露于原发性人支气管上皮细胞中引起的，并检测新的性别 特定的蛋白质生物标志物用于使用免疫学多路复用的肺上皮过敏性注射 分析技术平台。类似于父母奖及其相关多样性补充，这 通过研究病理生物学，行政补充与NHLBI的研究优先级相结合 对肺部疾病发作和进展至关重要的机制，确定了解释的因素 肺病病理学的个体差异，包括性别差异和性别的影响，以及 发展，多元化并维持能够完成研究所使命的科学劳动力。