CLINICAL TRIAL: NUTRITIONAL INTERVENTIONS FOR MAXIMAL MUSCLE GAIN IN MIDDLE-AGED

临床试验：中年人最大肌肉增长的营养干预

• 批准号: 7719200
• 负责人: Elena Volpi
• 金额: $ 0.4万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719200
• 关键词: Aging; Amino Acids; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Data; Dietary Intervention; Dose; Enrollment; Essential Amino Acids; Exercise; Funding; Grant; Growth; Institution; Muscle; Muscle Weakness; Nutritional; Persons; Pilot Projects; Placebos; Prevention; Randomized; Research; Research Personnel; Resources; Safety; Source; Supplementation; Testing; Training; United States National Institutes of Health; day; dietary supplements; middle age; pill; sedentary; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our studies in the past have focused on the short term effects of exercise and amino acids in sedentary subjects. We would like to expand our research to include recreationally active middle aged people looking at the effect of essential amino acid on muscle growth. We hypothesize that long-term nutritional supplementation with essential amino acids will grow muscle and increase strength in healthy, trained middle-aged people. We will determine if long-term nutritional supplementation with essential amino acids can grow muscle and increase strength in healthy, trained middle aged people. Enrolled subjects will be randomized to receive supplement or a placebo (i.e. like a sugar pill ) every day for one year. They will be tested every four months to check for muscle growth, strength testing, and safety of the supplements. At the end of the year all tests will be performed again to get the final results. This pilot study will serve to determine feasibility and safety of a nutritional intervention for muscle growth in trained middle-aged persons, and will allow us to collect preliminary data for a larger clinical trial to determine the optimal dose and composition of nutritional supplements for the prevention of muscle weakness and loss with aging.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们过去的研究主要集中在运动和氨基酸对久坐受试者的短期影响。我们希望扩大我们的研究范围，将休闲活跃的中年人纳入其中，研究必需氨基酸对肌肉生长的影响。 我们假设，长期补充必需氨基酸的营养可以让健康、训练有素的中年人生长肌肉并增强力量。 我们将确定长期补充必需氨基酸的营养是否可以让健康、训练有素的中年人生长肌肉并增强力量。 纳入的受试者将被随机分配，每天接受补充剂或安慰剂（即糖丸），持续一年。他们将每四个月接受一次测试，以检查肌肉生长、力量测试和补充剂的安全性。年底，所有测试将再次进行，以获得最终结果。 这项试点研究将有助于确定对受过训练的中年人进行肌肉生长营养干预的可行性和安全性，并使我们能够为更大规模的临床试验收集初步数据，以确定用于预防的营养补充剂的最佳剂量和成分。随着年龄的增长，肌肉无力和丧失。